公开(公告)号：US06280439B1

公开(公告)日：2001-08-28

申请号：US09352021

申请日：1999-07-12

申请人： Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  Miriam Lane

发明人： Robert Martin ,  Claudia Lueckge ,  Leonilda Capuano ,  Miriam Lane

IPC分类号： A61B1802

CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2018/00196 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A cryogenic catheter includes an outer flexible member having a cryogenic fluid path defined by an injection tube disposed in the outer flexible member. The injection tube is slidably disposed within the outer flexible member. A guide member may be provided to support the injection tube within the outer flexible member. A wire is attached to the injection tube at one end and further attached to a spool to provide for take-up of the wire.

摘要翻译： 低温导管包括具有由设置在外部柔性构件中的注射管限定的低温流体路径的外部柔性构件。 注射管可滑动地设置在外部柔性构件内。 可以设置引导构件以将注射管支撑在外部柔性构件内。 电线在一端连接到注射管，并进一步连接到线轴以提供线的卷绕。

公开(公告)号：US06270493B1

公开(公告)日：2001-08-07

申请号：US09356433

申请日：1999-07-19

申请人： Jean-Pierre Lalonde ,  Cristian Petre ,  Robert Martin ,  Claudia Lueckge ,  Sean Carroll ,  Dan Wittenberger ,  George Klein

发明人： Jean-Pierre Lalonde ,  Cristian Petre ,  Robert Martin ,  Claudia Lueckge ,  Sean Carroll ,  Dan Wittenberger ,  George Klein

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2018/00041 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268

摘要： A cryocatheter for treatment of tissue includes a coolant line communicating with a cryochamber having a coolant receiving interior and a thermally conductive wall for contacting and conductively treating tissue. A return line returns spent coolant, and an insert or partition in the cryochamber conditions flow or channels fluid from the coolant line to the return line to enhance the rate or uniformity of cooling. The partition may extend axially to define an elongated sub-chamber which is preferentially cooled, or it may isolate one side to define an uncooled side of the cryochamber. The partition may extend axially to define a sub-chamber extending along a segmented length around a partial circumference of the catheter tip, or may channel the coolant from a central region outwardly against the peripheral wall of the cryochamber. The return line may be a vacuum return line. The catheter may include a means for warming the catheter tip to warm up or accelerate thawing of treated tissue, and the heating may be implemented by a heater in thermal contact with a fluid supply line, which may, moreover, be the coolant supply line. Alternatively, the warming fluid supply line may be distinct from the coolant line. In one embodiment, the device may connect the warming line as an additional coolant return line during cryotreatment, and switch its connection to supply warming fluid after the tissue has been cooled. The catheter may further include sensors such as thermal or impedance sensors for sensing contact orientation of the catheter against adjacent tissue. Electrodes may apply signals of two different frequencies to the two sides, and a processor may determine frequency, impedance or a differential temperature to indicate the tip contact orientation.

摘要翻译： 用于治疗组织的低温灭菌器包括与具有冷却剂接收内部的冷冻箱和用于接触和导电地处理组织的导热壁连通的冷却剂管线。 返回管路返回耗尽的冷却剂，冷冻箱条件中的插入物或分隔件将流体从冷却剂管路流向或返回管路，以提高冷却速度或均匀性。 分隔件可以轴向延伸以限定优选冷却的细长子室，或者可以隔离一侧以限定冷冻箱的未冷却侧。 分隔件可以轴向延伸以限定围绕导管尖端的部分圆周的分段长度延伸的子室，或者可以将冷却剂从中心区域向外引导抵靠冷冻箱的周壁。 返回管线可以是真空回流管线。 导管可以包括用于加温导管尖端以加热或加速经处理的组织的解冻的装置，并且加热可以通过与流体供应管线热接触的加热器来实现，流体供应管线还可以是冷却剂供应管线。 或者，加温流体供应管线可以不同于冷却剂管线。 在一个实施例中，该装置可以在冷冻处理期间将加热管线作为另外的冷却剂返回管线连接，并且在组织冷却之后将其连接切换到供应加热流体。 导管还可以包括传感器，例如用于感测导管相对于相邻组织的接触取向的热传感器或阻抗传感器。 电极可以将两个不同频率的信号施加到两侧，并且处理器可以确定频率，阻抗或差分温度以指示尖端接触取向。