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公开(公告)号:US06280439B1
公开(公告)日:2001-08-28
申请号:US09352021
申请日:1999-07-12
申请人: Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
发明人: Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
IPC分类号: A61B1802
CPC分类号: A61B18/02 , A61B2017/00092 , A61B2018/00196 , A61B2018/0212 , A61B2018/0262
摘要: A cryogenic catheter includes an outer flexible member having a cryogenic fluid path defined by an injection tube disposed in the outer flexible member. The injection tube is slidably disposed within the outer flexible member. A guide member may be provided to support the injection tube within the outer flexible member. A wire is attached to the injection tube at one end and further attached to a spool to provide for take-up of the wire.
摘要翻译: 低温导管包括具有由设置在外部柔性构件中的注射管限定的低温流体路径的外部柔性构件。 注射管可滑动地设置在外部柔性构件内。 可以设置引导构件以将注射管支撑在外部柔性构件内。 电线在一端连接到注射管,并进一步连接到线轴以提供线的卷绕。
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公开(公告)号:US06283959B1
公开(公告)日:2001-09-04
申请号:US09378972
申请日:1999-08-23
申请人: Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
发明人: Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
IPC分类号: A61B1818
CPC分类号: A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要: A catheter is attached to an elongated catheter body adapted for endovascular insertion with a balloon assembly at its distal end. Coolant injected through the catheter body may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. A valve may regulate back pressure in the return passage to coordinate the flow of coolant into and out of the balloon so as to both inflate the balloon and achieve cryogenic cooling at the surface of the balloon. The coolant is biologically safe, and may be liquid carbon dioxide. Plural balloons may be provided adjacent the cooling segment, and one balloon may be shaped to treat the ostium of a vessel. Preferably, thermal conductivity of the balloon wall is enhanced by inclusion of thermally conductive material, such as metal, which may be introduced as a component of a composite elastomer material, or as a patterned metal layer that defines a pattern of thermally conductive treatment regions of the balloon surface. Patterns formed by printing, lithography or other means with copper, silver or other highly thermally conductive material enhance through-conduction characteristics of the wall so icing preferentially occurs to stimulate tissue destruction and vascular regeneration. Suitable patterns include spirals, dots, arrays of separated segments, or meandering curves which allow expansion of the balloon body without introducing delamination, localized stress cracking or separation of the balloon material. The conductive patterns may include patterns such as waffle-iron or other arrays of small lesions that are effective to treat the endovascular wall. When separate media are used for cooling and for balloon expansion, the cooling chamber may have a large diameter, and the balloon may form a thin shell or cuff. In that case, the balloon may be quickly inflated with a medium such as a saline to provide a quickly deployed and compliant contact structure of excellent conductivity.
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公开(公告)号:US06575933B1
公开(公告)日:2003-06-10
申请号:US09491239
申请日:2000-01-25
申请人: Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
发明人: Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
IPC分类号: A61M2900
CPC分类号: A61B18/02 , A61B2017/00867 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/00404 , A61B2018/00422 , A61B2018/0212 , A61B2018/025 , A61B2018/0262 , A61B2018/0281 , A61F2007/126 , A61M25/10 , A61M2025/1084 , A61M2205/3606
摘要: A medical implement that employs a mechanically supported expandable element. In one embodiment, the mechanically supported expandable element is a balloon. In another embodiment, the mechanically supported expandable membrane is a balloon disposed within a cryogenic catheter usable to treat tissue. A variety of illustrative mechanical support schemes are possible.
摘要翻译: 一种采用机械支撑的可扩张元件的医疗器具。 在一个实施例中,机械支撑的可膨胀元件是气球。 在另一个实施方案中,机械支撑的可膨胀膜是设置在可用于治疗组织的低温导管内的球囊。 各种说明性的机械支持方案是可能的。
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公开(公告)号:US07300433B2
公开(公告)日:2007-11-27
申请号:US10397619
申请日:2003-03-26
申请人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号: A61B18/18
CPC分类号: A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译: 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中,通过装置注入的冷却剂可以直接冷却接触气囊的组织,或者可以冷却单独的内部腔室。 在第一种情况下,冷却剂还使气囊膨胀,并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。 可以提供多个气球,其中次级外球囊围绕主内球囊,主气球填充有冷却剂并用作冷却室,次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置, 冷却室周围的绝热体。 可以采用各种构造,例如球囊界面的表面改性,或者在气球界面中放置颗粒,涂层或可膨胀的网孔或线圈,以实现该功能。
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公开(公告)号:US20060030843A1
公开(公告)日:2006-02-09
申请号:US11244710
申请日:2005-10-06
申请人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
发明人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
IPC分类号: A61B18/02
CPC分类号: A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
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公开(公告)号:US06575966B2
公开(公告)日:2003-06-10
申请号:US09945319
申请日:2001-08-31
申请人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号: A61B1818
CPC分类号: A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
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公开(公告)号:US07648497B2
公开(公告)日:2010-01-19
申请号:US11244710
申请日:2005-10-06
申请人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人: Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号: A61B18/18
CPC分类号: A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要: An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译: 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中,通过装置注入的冷却剂可以直接冷却接触气囊的组织,或者可以冷却单独的内部腔室。 在第一种情况下,冷却剂还使气囊膨胀,并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。 可以提供多个气球,其中次级外球囊围绕主内球囊,主气球填充有冷却剂并用作冷却室,次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置, 冷却室周围的绝热体。 可以采用各种构造,例如球囊界面的表面改性,或者在气球界面中放置颗粒,涂层或可膨胀的网孔或线圈,以实现该功能。
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公开(公告)号:US20060270981A1
公开(公告)日:2006-11-30
申请号:US11129044
申请日:2005-05-13
申请人: Leonilda Capuano , Robert Martin , Teresa Mihalik
发明人: Leonilda Capuano , Robert Martin , Teresa Mihalik
CPC分类号: A61B18/02 , A61B2017/22038 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要: A medical device includes a catheter having a proximal end and a distal end, the catheter defining a lumen. A passage for a guide wire is disposed within the lumen so as to be coaxial with the lumen. The passage has an open proximal end that is substantially coterminous with the proximal end of the catheter and an open distal end that is substantially coterminous with the distal end of the catheter. A fluid injection tube is wound around the passage for the guide wire and is provided with radially spaced fluid injection ports.
摘要翻译: 医疗装置包括具有近端和远端的导管,所述导管限定内腔。 用于引导线的通道设置在内腔内以与内腔同轴。 通道具有与导管的近端基本相邻的开放近端,以及与导管的远端基本上相邻的开口远端。 流体注入管缠绕在用于导丝的通道周围,并且设置有径向间隔开的流体注入口。
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公开(公告)号:US07912554B2
公开(公告)日:2011-03-22
申请号:US11119368
申请日:2005-04-29
申请人: Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
发明人: Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
IPC分类号: A61F2/00
CPC分类号: A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要: A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译: 公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。 该方法通过用低温冷却装置冷却血管壁来增加,增强或增加血管壁的密度。 该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁,以延迟或停止动脉瘤或血管缺损形成。 能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。 可以使用包括可见光能量,激光能量,超声波,微波和射频源在内的各种形式的能量照射和治疗动脉瘤。 此外,该方法可以包括与其它治疗伴随地照射组织部位,包括将血管闭塞化合物,机械血管内装置或血管内移植物递送至靶组织区域。
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公开(公告)号:US20050222649A1
公开(公告)日:2005-10-06
申请号:US11119368
申请日:2005-04-29
申请人: Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
发明人: Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
CPC分类号: A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要: A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译: 公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。 该方法通过用低温冷却装置冷却血管壁来增加,增强或增加血管壁的密度。 该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁,以延迟或停止动脉瘤或血管缺损形成。 能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。 可以使用包括可见光能量,激光能量,超声波,微波和射频源在内的各种形式的能量照射和治疗动脉瘤。 此外,该方法可以包括与其它治疗伴随地照射组织部位,包括将血管闭塞化合物,机械血管内装置或血管内移植物递送至靶组织区域。
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