公开(公告)号：US20060078623A1

公开(公告)日：2006-04-13

申请号：US11204778

申请日：2005-08-15

申请人： Nikhil Dhoot ,  Halina Levchik ,  Shingai Majuru ,  George Klein ,  Jamila Harris ,  Puchun Liu ,  Steven Dinh ,  Jun Liao ,  Jongbin Lee ,  Ehud Arbit ,  Nai Wang

发明人： Nikhil Dhoot ,  Halina Levchik ,  Shingai Majuru ,  George Klein ,  Jamila Harris ,  Puchun Liu ,  Steven Dinh ,  Jun Liao ,  Jongbin Lee ,  Ehud Arbit ,  Nai Wang

IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K9/14

CPC分类号： A61K47/12 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2846 ,  A61K9/4858 ,  A61K38/28

摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.

摘要翻译： 本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。 本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

公开(公告)号：US06730077B2

公开(公告)日：2004-05-04

申请号：US10237376

申请日：2002-09-09

申请人： Sean Carroll ,  George Klein ,  Marwan Abboud ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger

发明人： Sean Carroll ,  George Klein ,  Marwan Abboud ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger

IPC分类号： A61B1802

CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/065

摘要： A cryocatheter for treatment of tissue has a tip adapted to provide a signal indicative of the quality and/or orientation of the tip contact with surrounding tissue. In one embodiment, a signal conductor extends through the catheter to the tip and connects to a thermally and electrically conductive shell or cap that applies an RF current to the region of tissue contacted by the tip. The tissue impedance path between the signal lead and a surface electrode mounted on the patient's skin is monitored to develop a quantitative measure of tissue contact at the distal tip, which is preferably displayed on the screen of a catheter monitoring console. In yet a further embodiment, the catheter is provided with a split tip having temperature monitoring sensors, such as thermistors, mounted on opposed halves of the tip so as to sense temperature on two sides of the catheter axis. The thermistor signals are processed to determine and display differential temperature between the two sides of the tip, thus revealing which side lies in contact. In yet a further aspect of the first embodiment, two separate and distinct high frequency electrical signals are applied to the two halves of a split metal shell or cap at the tip. Signals received at the surface electrode are filtered into first and second frequency components, and these are processed to determine the relative magnitude of the signal or the impedance of the path for each of the injected signals to determine and display the tissue contact orientation of the catheter. The catheter preferably has two separate cooling chambers within the cooling tip, positioned with one chamber on each side of the axis, and a separate cooling inlet to each chamber is switched on by a valve which directs the flow of coolant to the contact side during active cryotreatment. In another embodiment, the cap provides an RF electrode that may be opposed to the cooling side so that either the cryogenic or the RF ablation side may be rotated into contact to selectively heat or cool, or in representative protocol treat, then thaw, the same tissue site.

公开(公告)号：US20140200577A1

公开(公告)日：2014-07-17

申请号：US14115595

申请日：2012-05-03

申请人： George Klein ,  Harold Wodlinger ,  Steve Wayne Berhow ,  Douglas Scott Wahnschaffe

发明人： George Klein ,  Harold Wodlinger ,  Steve Wayne Berhow ,  Douglas Scott Wahnschaffe

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2018/00196 ,  A61B2018/00273 ,  A61B2018/00351 ,  A61B2018/00482 ,  A61B2018/00505 ,  A61B2018/00541 ,  A61B2218/002

摘要： The present invention provides improved catheters for ablative procedures for biological tissue, e.g., in the heart. The catheters allow active fixation to the tissue using a pair of jaws, and a sheath actuates the jaws, simplifying actuation. In particular embodiments, the pair of jaws provides additional stability in attachment to difficult ablation sites, e.g., along the ridges of cardiac structures.

摘要翻译： 本发明提供了用于例如在心脏中的用于生物组织的烧蚀程序的改进的导管。 导管允许使用一对钳口主动固定到组织，并且护套致动钳口，从而简化致动。 在特定实施例中，该对钳口在附着到难消化部位（例如沿着心脏结构的脊）提供额外的稳定性。

公开(公告)号：US20120046666A1

公开(公告)日：2012-02-23

申请号：US13202854

申请日：2010-02-24

申请人： George Klein

发明人： George Klein

IPC分类号： A61B17/00

CPC分类号： A61M25/0662 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00898 ,  A61M25/0068 ,  A61M25/0082 ,  A61M25/01 ,  A61M25/04 ,  A61M25/10 ,  A61M2025/0681

摘要： In general, the invention provides improved sheaths for enhanced control over the relative position of the sheath or inserted catheter relative to a biological tissue. The invention also provides improved sheaths for controlling the longitudinal and axial movement of inserted catheters relative to the sheath. The sheaths include an active anchor at the distal end capable of reversibly adhering the sheath to a tissue. Exemplary active anchors include a reversibly inflatable balloon, a deflectable tip, a suction cup, a screw, and a barb.

摘要翻译： 通常，本发明提供改进的护套，用于增强对鞘或插入的导管相对于生物组织的相对位置的控制。 本发明还提供了改进的护套，用于控制插入的导管相对于护套的纵向和轴向运动。 护套包括能够将护套可逆地粘附到组织的远端处的活性锚固件。 示例性的活动锚固件包括可逆膨胀的气囊，可偏转的尖端，吸盘，螺钉和倒钩。

公开(公告)号：US20080103493A1

公开(公告)日：2008-05-01

申请号：US11969321

申请日：2008-01-04

申请人： Marwan ABBOUD ,  Fredric MILDER ,  George KLEIN

发明人： Marwan ABBOUD ,  Fredric MILDER ,  George KLEIN

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

公开(公告)号：US20080091180A1

公开(公告)日：2008-04-17

申请号：US11953189

申请日：2007-12-10

申请人： Marwan ABBOUD ,  Fredric MILDER ,  George KLEIN

发明人： Marwan ABBOUD ,  Fredric MILDER ,  George KLEIN

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

公开(公告)号：US07085601B1

公开(公告)日：2006-08-01

申请号：US09441936

申请日：1999-11-17

申请人： Gust H. Bardy ,  George Klein

发明人： Gust H. Bardy ,  George Klein

IPC分类号： A61N1/39

CPC分类号： A61N1/39 ,  A61N1/395 ,  A61N1/3956 ,  A61N1/3987

摘要： An atrial defibrillator includes a portable, non-implantable housing, a pair of defibrillator pads, a shock generator, and an analyzer. The pads are applied to the outside of a patient's body, and the shock generator delivers a shock to the patient via the pads. The analyzer receives a cardiac signal from the patient, determines from the signal whether the patient is experiencing atrial fibrillation, and enables the shock generator if the patient is experiencing atrial fibrillation. Unlike conventional external atrial defibrillators, such an atrial defibrillator can be used by a layperson in the comfort of a patient's own home. Furthermore, such a defibrillator does not cause the surgery-related problems associated with implantable atrial defibrillators. Moreover, because the patient can choose when to receive a shock, such a defibrillator is less likely to surprise and embarrass the patient than automatic implantable defibrillators are.

摘要翻译： 心房除颤器包括便携式非植入式外壳，一对除颤器垫，冲击发生器和分析器。 垫被施加到患者身体的外部，并且冲击发生器通过垫片向患者传递冲击。 分析仪从患者接收心脏信号，根据信号确定患者是否正在经历心房颤动，并且如果患者正在经历心房纤维性颤动，则能够进行休克发生器。 与传统的外部心房除颤器不同，这种心房除颤器可以由外行人在患者自己的家中舒适地使用。 此外，这种除颤器不会引起与可植入心房除颤器相关的手术相关问题。 此外，由于患者可以选择何时接受休克，因此与自动植入性除颤器相比，这种除颤器不太可能令人惊奇，并且使患者感到尴尬。

公开(公告)号：US20060069410A1

公开(公告)日：2006-03-30

申请号：US11244764

申请日：2005-10-06

申请人： Rahul Mehra ,  George Klein ,  Michael Ujhelyi

发明人： Rahul Mehra ,  George Klein ,  Michael Ujhelyi

IPC分类号： A61N1/365

CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

公开(公告)号：US06471693B1

公开(公告)日：2002-10-29

申请号：US09393461

申请日：1999-09-10

申请人： Sean Carroll ,  George Klein

发明人： Sean Carroll ,  George Klein

IPC分类号： A61B1802

CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/065

摘要： A cryocatheter for treatment of tissue has a tip adapted to provide a signal indicative of the quality and/or orientation of the tip contact with surrounding tissue. In one embodiment, a signal conductor extends through the catheter to the tip and connects to a thermally and electrically conductive shell or cap that applies an RF current to the region of tissue contacted by the tip. The tissue impedance path between the signal lead and a surface electrode mounted on the patient's skin is monitored to develop a quantitative measure of tissue contact at the distal tip, which is preferably displayed on the screen of a catheter monitoring console. In yet a further embodiment, the catheter is provided with a split tip having temperature monitoring sensors, such as thermistors, mounted on opposed halves of the tip so as to sense temperature on two sides of the catheter axis. The thermistor signals are processed to determine and display differential temperature between the two sides of the tip, thus revealing which side lies in contact. In yet a further aspect of the first embodiment, two separate and distinct high frequency electrical signals are applied to the two halves of a split metal shell or cap at the tip. Signals received at the surface electrode are filtered into first and second frequency components, and these are processed to determine the relative magnitude of the signal or the impedance of the path for each of the injected signals to determine and display the tissue contact orientation of the catheter. The catheter preferably has two separate cooling chambers within the cooling tip, positioned with one chamber on each side of the axis, and a separate cooling inlet to each chamber is switched on by a valve which directs the flow of coolant to the contact side during active cryotreatment. In another embodiment, the cap provides an RF electrode that may be opposed to the cooling side so that either the cryogenic or the RF ablation side may be rotated into contact to selectively heat or cool, or in representative protocol treat, then thaw, the same tissue site.

公开(公告)号：US06270493B1

公开(公告)日：2001-08-07

申请号：US09356433

申请日：1999-07-19

申请人： Jean-Pierre Lalonde ,  Cristian Petre ,  Robert Martin ,  Claudia Lueckge ,  Sean Carroll ,  Dan Wittenberger ,  George Klein

发明人： Jean-Pierre Lalonde ,  Cristian Petre ,  Robert Martin ,  Claudia Lueckge ,  Sean Carroll ,  Dan Wittenberger ,  George Klein

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2018/00041 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268

摘要： A cryocatheter for treatment of tissue includes a coolant line communicating with a cryochamber having a coolant receiving interior and a thermally conductive wall for contacting and conductively treating tissue. A return line returns spent coolant, and an insert or partition in the cryochamber conditions flow or channels fluid from the coolant line to the return line to enhance the rate or uniformity of cooling. The partition may extend axially to define an elongated sub-chamber which is preferentially cooled, or it may isolate one side to define an uncooled side of the cryochamber. The partition may extend axially to define a sub-chamber extending along a segmented length around a partial circumference of the catheter tip, or may channel the coolant from a central region outwardly against the peripheral wall of the cryochamber. The return line may be a vacuum return line. The catheter may include a means for warming the catheter tip to warm up or accelerate thawing of treated tissue, and the heating may be implemented by a heater in thermal contact with a fluid supply line, which may, moreover, be the coolant supply line. Alternatively, the warming fluid supply line may be distinct from the coolant line. In one embodiment, the device may connect the warming line as an additional coolant return line during cryotreatment, and switch its connection to supply warming fluid after the tissue has been cooled. The catheter may further include sensors such as thermal or impedance sensors for sensing contact orientation of the catheter against adjacent tissue. Electrodes may apply signals of two different frequencies to the two sides, and a processor may determine frequency, impedance or a differential temperature to indicate the tip contact orientation.

摘要翻译： 用于治疗组织的低温灭菌器包括与具有冷却剂接收内部的冷冻箱和用于接触和导电地处理组织的导热壁连通的冷却剂管线。 返回管路返回耗尽的冷却剂，冷冻箱条件中的插入物或分隔件将流体从冷却剂管路流向或返回管路，以提高冷却速度或均匀性。 分隔件可以轴向延伸以限定优选冷却的细长子室，或者可以隔离一侧以限定冷冻箱的未冷却侧。 分隔件可以轴向延伸以限定围绕导管尖端的部分圆周的分段长度延伸的子室，或者可以将冷却剂从中心区域向外引导抵靠冷冻箱的周壁。 返回管线可以是真空回流管线。 导管可以包括用于加温导管尖端以加热或加速经处理的组织的解冻的装置，并且加热可以通过与流体供应管线热接触的加热器来实现，流体供应管线还可以是冷却剂供应管线。 或者，加温流体供应管线可以不同于冷却剂管线。 在一个实施例中，该装置可以在冷冻处理期间将加热管线作为另外的冷却剂返回管线连接，并且在组织冷却之后将其连接切换到供应加热流体。 导管还可以包括传感器，例如用于感测导管相对于相邻组织的接触取向的热传感器或阻抗传感器。 电极可以将两个不同频率的信号施加到两侧，并且处理器可以确定频率，阻抗或差分温度以指示尖端接触取向。