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公开(公告)号：US20210371538A1
公开(公告)日：2021-12-02
申请号：US17314946
申请日：2021-05-07
Applicant: GENMAB A/S
Inventor： Tahamtan AHMADI , Manish GUPTA , Tommy LI , Roberto OLIVERI , Dena DEMARCO , Ida HIEMSTRA , Christopher CHIU , Brian ELLIOTT , Ada AZARYAN
IPC: C07K16/28 , A61K31/573 , A61K45/06 , A61K39/395 , A61P35/00
Abstract: The present invention relates to bispecific antibodies (bsAbs) and the use of such antibodies in the treatment of disease in subjects. Moreover, advantageous treatment regimens are provided for the treatment of B-cell Non-Hodgkin Lymphoma (B-NHL).
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公开(公告)号：US20210269509A1
公开(公告)日：2021-09-02
申请号：US17253286
申请日：2019-06-24
Applicant: GENMAB A/S
Inventor： Richard HIBBERT , Rob DE JONG , Aran Frank LABRIJN , Arnout GERRITSEN , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to a method for controlling the composition of a mixture of two or more different antibodies, such as tow or more different monoclonal antibodies, using chromatography. The mixture is for use as a drug product and the method includes a controlled downstream process for the production of a predetermined ratio of the two or more different antibodies.
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公开(公告)号：US20210253725A1
公开(公告)日：2021-08-19
申请号：US17144591
申请日：2021-01-08
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur Sahin , Friederike Gieseke , Isil Altintas , David Satijn , Paul Parren
IPC: C07K16/28
Abstract: The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.
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公开(公告)号：US20210230296A1
公开(公告)日：2021-07-29
申请号：US17228023
申请日：2021-04-12
Applicant: GENMAB A/S
Inventor： David SATIJN , Esther C. W. BREIJ , Bart E. C. G. DE GOEIJ , Kristel KEMPER , Patrick ENGELBERTS , Edward N. VAN DEN BRINK , Rik RADEMAKER , Dennis VERZIJL , Sjeng HORBACH , Paul PARREN
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US11008399B2
公开(公告)日：2021-05-18
申请号：US17077376
申请日：2020-10-22
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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Patent Agency Ranking
公开(公告)号：US20210015939A1
公开(公告)日：2021-01-21
申请号：US16982008
申请日：2019-03-20
Applicant: Genmab A/S
Inventor： Reshma Abdulla RANGWALA , Esther C.W. BREIJ , Sandra VERPLOEGEN , Oyewale O. ABIDOYE , Leonardo Viana NICACIO
IPC: A61K47/68 , A61P35/00 , A61K31/555 , A61K9/00
Abstract: The invention provides a platinum-based agent (e.g., carboplatin) in combination with an antibody-drug conjugate that binds to tissue factor (TF) (e.g., tisotumab vedotin) and their use in methods of treating cancer, such as bladder cancer and cervical cancer. The invention also provides compositions and kits comprising the platinum-based agent (e.g., carboplatin) and the antibody-drug conjugate that binds to TF (e.g., tisotumab vedotin) for use in treating cancer, such as bladder cancer and cervical cancer.
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公开(公告)号：US10793640B2
公开(公告)日：2020-10-06
申请号：US15627921
申请日：2017-06-20
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Edward N. Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC: C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US10765743B2
公开(公告)日：2020-09-08
申请号：US16248402
申请日：2019-01-15
Applicant: GENMAB A/S
Inventor： Esther Breij , David Satijn , Edward Norbert Van Den Brink , Dennis Verzijl , Rob N. De Jong , Paul Parren , Riemke Van Dijkhuizen Radersma
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US10597464B2
公开(公告)日：2020-03-24
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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公开(公告)号：US10407501B2
公开(公告)日：2019-09-10
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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