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公开(公告)号：US11261440B2
公开(公告)日：2022-03-01
申请号：US16487762
申请日：2018-02-20
Applicant: Osaka University
Inventor： Satoshi Obika , Reiko Waki , Takao Inoue , Tokuyuki Yoshida , Kunihiko Morihiro , Yuya Kasahara , Atsushi Mikami
IPC: C12N15/113 , A61K31/7115 , A61K31/712
Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2′,4′-bridged nucleic acids, 2′,4′-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2′,4′-non-bridged nucleic acid residue(s) is/are modified.
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公开(公告)号：US20220057676A1
公开(公告)日：2022-02-24
申请号：US17299710
申请日：2019-11-28
Applicant: OSAKA UNIVERSITY
Inventor： Hiroyuki YOSHIDA , SeongYong CHO , Masanori OZAKI
IPC: G02F1/1335 , G02F1/137 , G02F1/13357 , F21V8/00
Abstract: A display device includes an optical waveguide layer, a variable refractive index layer, and an optical layer. The refractive index of the variable refractive index layer changes in response to application of a drive voltage. The optical layer reflects or absorbs light. The variable refractive index layer reflects the light to be guided through the optical waveguide layer 11 toward the inside of the optical waveguide layer depending on the refractive index of the variable refractive index layer to allow the optical waveguide layer to guide the reflected light. The variable refractive index layer introduces the light to be guided through the optical waveguide layer into the variable refractive index layer depending on the refractive index of the variable refractive index layer and emits the introduced light out of the variable refractive index layer. The optical layer reflects or absorbs the light emitted from the variable refractive index layer.
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公开(公告)号：US11234645B2
公开(公告)日：2022-02-01
申请号：US16069503
申请日：2016-08-05
Applicant: OSAKA UNIVERSITY
Inventor： Tsuyoshi Sekitani , Takafumi Uemura , Teppei Araki , Shusuke Yoshimoto
Abstract: A biosignal measurement apparatus that is used by being affixed on a living body is provided with: an affixed part that is a sheet, in which a signal-acquiring section of multiple electrodes and wiring connected to each of the electrodes are formed, and which can be freely expanded, contracted and bent and is adhesive; and a substrate that is connected to the wiring and on which a signal-processing circuit for wirelessly transmitting biosignals obtained through the wiring is mounted. The signal-acquiring section is exposed on the surface of the affixed part and the affixed part and the substrate are stacked so that the back surface of the affixed part faces the substrate.
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公开(公告)号：US11232789B2
公开(公告)日：2022-01-25
申请号：US16301665
申请日：2017-05-19
Inventor： Hiroaki Sugiyama , Toyomi Meguro , Junji Yamato , Yuichiro Yoshikawa , Hiroshi Ishiguro , Takamasa Iio , Tsunehiro Arimoto
Abstract: The present invention keeps a dialogue continuing for a long time without causing uncomfortable feeling to a user. A dialogue system 10 includes at least an input part 1 that receives a user utterance, which is an utterance from a user and a presentation part 5 that presents the utterance. The input part 1 receives a user utterance performed by the user. A presentation part 5-1 presents a dialogue-establishing utterance which does not include any content words. A presentation part 5-2 presents a second utterance associated with a generation target utterance, which is one or more utterances performed before user utterance that includes at least the user utterance, after the dialogue-establishing utterance.
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公开(公告)号：US11222634B2
公开(公告)日：2022-01-11
申请号：US16491442
申请日：2018-01-26
Inventor： Hiroaki Sugiyama , Hiromi Narimatsu , Yuichiro Yoshikawa , Takamasa Iio , Tsunehiro Arimoto , Hiroshi Ishiguro
Abstract: It is an object of the present invention to induce a dialogue to a topic that a dialogue system tries to present. A dialogue system 100 presents a first utterance which is a certain utterance and a target utterance related to the first utterance to a user 101. A humanoid robot 50-1 presents the first utterance. A microphone 11-1 receives a user utterance of the user 101 after the first utterance. A humanoid robot 50-2 presents at least one topic-inducing utterance for inducing the topic to the target utterance based on a recognition result of the user utterance and an utterance sentence of the target utterance after the user utterance. The humanoid robot 50-1 presents the target utterance after the topic-inducing utterance.
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Patent Agency Ranking
公开(公告)号：US11220757B2
公开(公告)日：2022-01-11
申请号：US14363090
申请日：2012-12-05
Applicant: OSAKA UNIVERSITY
Inventor： Kazuto Yamauchi
Abstract: Provided is a method for manufacturing a solid oxide and a device therefor, capable of manufacturing a solid oxide used as an optical material without introducing damaged layers caused by machining, which does not use any polishing agent or abrasive grains including rare earth elements, or does not use any solution, such as hydrogen fluoride, for which handling is difficult and which imposes a heavy environmental burden. In the presence of water 1, a solid oxide in which one or more kinds of elements are bonded through oxygen is used as an object to be manufactured; a catalyst substance, which cuts a backbond between an oxygen element and another element, forming the solid oxide, by dissociation of a water molecule, and adsorbs it, and helps production of a decomposition product by hydrolysis, is used as a machining reference surface (3); the object (5) to be manufactured and the machining reference surface are disposed so that they are brought into contact with each other or they are brought very close to each other in the presence of water; a potential of the machining reference surface is adjusted to a range where neither H2 nor O2 is produced; and the object to be manufactured is moved relative to the machining reference surface thereby to remove a decomposition product from the surface of the object to be manufactured.
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公开(公告)号：US20220005222A1
公开(公告)日：2022-01-06
申请号：US17280698
申请日：2019-09-24
Applicant: OSAKA UNIVERSITY
Inventor： Chihiro TANIKAWA , Chonho LEE
Abstract: A technique for automating the identifying of a measurement point in cephalometric image analysis is provided. An automatic measurement point recognition method includes a step of detecting, from a cephalometric image 14 acquired from a subject, a plurality of peripheral partial regions 31, 32, 33, 34 for recognizing a target feature point, a step of estimating a candidate position of the feature point in each of the peripheral partial regions 31, 32, 33, 34 by the application of a regression CNN model 10, and a step of determining the position of the feature point in the cephalometric image 14 based on the distribution of the candidate positions estimated. In the step of detecting, for example, the peripheral partial region 32, a classification CNN model 13 trained with a control image 52 is applied.
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公开(公告)号：US20220004913A1
公开(公告)日：2022-01-06
申请号：US16628989
申请日：2018-07-06
Applicant: Osaka University
Inventor： Aya NAKAE
Abstract: A high accuracy information extracting device construction system includes: a feature quantity extraction expression list generating unit for generating a feature quantity extraction expression list; a feature quantity calculating unit for calculating feature quantities of teacher data by means of respective feature quantity extracting expressions; a teacher data supply unit for supplying teacher data; an evaluation value calculating unit for generating information extracting expressions by means of machine learning on the basis of the calculated feature quantities of teacher data and the teacher data, and calculating evaluation values for the respective feature quantity extracting expressions; and a synthesis unit for constructing a high accuracy information extracting device using T weak information extracting parts F(X)t output from the evaluation value calculating unit 15 and confidence levels Ct corresponding thereto.
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公开(公告)号：US20220003774A1
公开(公告)日：2022-01-06
申请号：US17374777
申请日：2021-07-13
Applicant: Osaka University , Kagami Inc.
Inventor： Yoshitaka ISAKA , Tomonori KIMURA , Keiko YASUDA , Kenji Hamase , Masashi MITA
Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
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公开(公告)号：US20220002904A1
公开(公告)日：2022-01-06
申请号：US17359949
申请日：2021-06-28
Applicant: OSAKA UNIVERSITY , Panasonic Corporation
Inventor： Yusuke MORI , Masashi YOSHIMURA , Masayuki IMANISHI , Akira KITAMOTO , Junichi TAKINO , Tomoaki SUMI , Yoshio OKAYAMA
Abstract: A method of manufacturing a group III nitride crystal according to a first aspect includes: preparing a seed substrate; generating a group III element oxide gas; supplying the group III element oxide gas; supplying a nitrogen element-containing gas; supplying an oxidizing gas containing nitrogen element containing at least one selected from the group consisting of NO gas, NO2 gas, N2O gas, and N2O4 gas; and growing the group III nitride crystal on the seed substrate.
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