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    RESOLVING SPATIAL ARRAYS BY PROXIMITY-BASED DECONVOLUTION
    133.
    发明申请
    RESOLVING SPATIAL ARRAYS BY PROXIMITY-BASED DECONVOLUTION 有权

    公开(公告)号：US20220112486A1

    公开(公告)日：2022-04-14

    申请号：US17312625

    申请日：2019-12-06

    Applicant: 10x Genomics, Inc.

    Inventor： Eswar Prasad Ramachandran Iyer ,  Tarjei Sigurd Mikkelsen ,  Benjamin Hindson ,  Paul Giresi ,  Lucas Frenz

    IPC: C12N15/10 ,  C12Q1/6874 ,  C12Q1/6837

    Abstract: Methods for determining a location of a feature in a spatial array with features include: (a) providing an array with a first set of one or more features immobilized on a substrate, a first feature of the first set having a first barcoded oligonucleotide with a first spatial barcode and a first constant sequence, and a second set of one or more features immobilized on the substrate, a second feature of the second set having a second barcoded oligonucleotide with a second spatial barcode and a second constant sequence; (b) attaching the first constant sequence to the second constant sequence to generate a nucleic acid product; (c) determining all or a portion of a sequence of the nucleic acid product or a complement thereof; and (d) associating the second barcoded oligonucleotide with the first barcoded oligonucleotide in the nucleic acid product.

    CAPSULE ARRAY DEVICES AND METHODS OF USE
    134.
    发明申请
    CAPSULE ARRAY DEVICES AND METHODS OF USE 有权

    公开(公告)号：US20220081704A1

    公开(公告)日：2022-03-17

    申请号：US17353202

    申请日：2021-06-21

    Applicant: 10X Genomics, Inc.

    Inventor： Benjamin Hindson ,  Serge Saxonov ,  Michael Schnall-Levin

    IPC: C12Q1/6806 ,  B01L3/00 ,  C12N15/10 ,  B01J19/00

    Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.

    Capsule array devices and methods of use
    137.
    发明授权
    Capsule array devices and methods of use 有权

    公开(公告)号：US11078522B2

    公开(公告)日：2021-08-03

    申请号：US16519863

    申请日：2019-07-23

    Applicant: 10X Genomics, Inc.

    Inventor： Benjamin Hindson ,  Serge Saxonov ,  Michael Schnall-Levin

    IPC: C12Q1/6806 ,  B01L3/00 ,  C12N15/10 ,  B01J19/00

    Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.

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