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公开(公告)号：US11253857B2
公开(公告)日：2022-02-22
申请号：US16605927
申请日：2018-03-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: An example system includes an input channel to flow nucleic segments therethrough, a mixing portion coupled to the input channel, a separation chamber in fluid communication with the second end of the input channel, at least two output channels coupled to the chamber, and an integrated pump to facilitate flow through the separation chamber. The mixing portion is to include at least two different categories of beads having different sizes from each other and having a probe to attach to a corresponding nucleic acid segment. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of the different categories of beads and attached corresponding nucleic acid segment into at least two flow paths based on a size of the category of the beads. Each output channel is to receive separated categories of beads and attached nucleic acid segments.
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公开(公告)号：US11235324B2
公开(公告)日：2022-02-01
申请号：US16643954
申请日：2017-11-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Adam Higgins , Alexander Govyadinov , Michael W. Cumbie
Abstract: The present disclosure is drawn to temperature-cycling microfluidic devices. In one example, a temperature-cycling microfluidic device can include a driver chip having a top surface and a heat exchange substrate having a top surface coplanar with the top surface of the driver chip. A fluid chamber can be located on the top surface of the driver chip. A first and second microfluidic loop can have fluid driving ends and fluid outlet ends connected to the fluid chamber and can include portions thereof located on the top surface of the heat exchange substrate. A first and second fluid actuator can be on the driver chip. The first and second fluid actuators can be associated with the fluid driving ends of the first and second microfluidic loops, respectively, to circulate fluid through the first and second microfluidic loops.
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公开(公告)号：US20210346885A1
公开(公告)日：2021-11-11
申请号：US17059650
申请日：2019-02-01
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexander Govyadinov , Viktor Shkolnikov , Diane R. Hammerstad
Abstract: In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes an analytic device. The analytic device includes a chamber to receive a cell to be analyzed. At least one lysing element agitates the cell and at least one sensor detects a change in the cell based on an agitation of the cell. The cellular analytic system also includes a controller to determine a rupture threshold of the cell based on parameters of the agitation when a cell membrane ruptures.
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公开(公告)号：US20210331482A1
公开(公告)日：2021-10-28
申请号：US16606761
申请日：2018-07-17
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander Govyadinov , Pavel Kornilovich , Diane R Hammerstad
Abstract: An example device includes a first substrate including a first array of droplet ejectors to eject droplets of a first fluid. The example device further includes a first target medium immovably positioned relative to the first substrate to receive droplets of the first fluid from a first subset of droplet ejectors of the first array of droplet ejectors. A second subset of droplet ejectors of the first array of droplet ejectors is positioned to eject droplets of the first fluid to miss the first target medium.
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公开(公告)号：US11110453B2
公开(公告)日：2021-09-07
申请号：US16492334
申请日：2017-04-07
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexander Govyadinov , Adam Higgins , Pavel Kornilovich
IPC: B01L3/00
Abstract: The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a microfluidic channel. A vent chamber can be in fluid communication with the microfluidic channel. A capillary break can be located between the microfluidic channel and the vent chamber. The capillary break can include a tapered portion and a narrowed opening with a smaller width than a width of the microfluidic channel. A vent port can vent gas from the vent chamber. The vent port can be located a distance away from the capillary break so that a fluid in the capillary break does not escape through the vent port.
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Patent Agency Ranking
公开(公告)号：US20210238537A1
公开(公告)日：2021-08-05
申请号：US17049406
申请日：2018-08-10
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander Govyadinov , Diane R. Hammerstad , Viktor Shkolnikov
Abstract: In one example in accordance with the present disclosure, a conductivity-based lysis monitor is described. The lysis monitoring device includes a lysing chamber to receive a cell to be lysed and at least one lysing device to rupture a cell membrane. At least one pair of electrodes are disposed in the lysing chamber to detect a level of conductivity in the lysing chamber. A controller of the device determines when the cell membrane has ruptured based on detected levels of conductivity in the lysing chamber.
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公开(公告)号：US11059290B2
公开(公告)日：2021-07-13
申请号：US16095575
申请日：2016-07-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander Govyadinov , Tsuyoshi Yamashita , Nicholas McGuinness , David P Markel , Erik D Tornianen
Abstract: A fluid ejection device includes a fluid slot, three laterally adjacent fluid ejection chambers each having a drop ejecting element therein, a fluid circulation path communicated with each of the three laterally adjacent fluid ejection chambers, and a fluid circulating element within the fluid circulation path, with at least two laterally adjacent fluid ejection chambers of the three laterally adjacent fluid ejection chambers to substantially simultaneously eject drops of fluid therefrom such that the drops of fluid are to coalesce during flight.
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公开(公告)号：US11027545B2
公开(公告)日：2021-06-08
申请号：US16343303
申请日：2017-01-31
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Tracy A Lang , Alexander Govyadinov
Abstract: A fluid ejection device includes a fluid ejection chamber having a drop ejecting element therein, a first fluid channel to communicate a first fluid with the fluid ejection chamber, a second fluid channel to communicate a second fluid different than the first fluid with the fluid ejection chamber, and a fluid pump communicated with one of the first fluid channel and the second fluid channel. As such, the fluid ejection chamber is to selectively eject drops of the first fluid, the second fluid, and a combination of the first fluid and the second fluid therefrom.
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公开(公告)号：US10766272B2
公开(公告)日：2020-09-08
申请号：US16217140
申请日：2018-12-12
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander Govyadinov , Tommy D Deskins
Abstract: A fluid ejection device may include a series of spaced two-sided walls forming three channels therebetween. Each of the three channels may contain a drop ejector. The device may further include a fluid circulating element to circulate fluid across the drop ejector within each of the channels.
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公开(公告)号：US10646868B2
公开(公告)日：2020-05-12
申请号：US16079496
申请日：2016-04-28
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Erik D. Torniainen , Nick McGuinness , David P. Markel , Alexander Govyadinov
Abstract: In an example implementation, a method of microfluidic filtering includes activating a first fluid pump within a microfluidic channel to cause a forward flow of fluid through the microfluidic channel and through a filter of a filter loop. The filter loop intersects the microfluidic channel at a loop entry and at a loop exit. The method includes activating a second fluid pump to cause a reverse flow of fluid through the filter.
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