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公开(公告)号：US20240299942A1
公开(公告)日：2024-09-12
申请号：US18573690
申请日：2021-06-30
发明人： Carson Denison , Pavel Kornilovich , Alexander Govyadinov , Erik D. Torniainen , Richard W. Seaver , Anand Samuel Jebakumar
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/086
摘要： A microfluidic device includes a chamber having a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has a leading surface or corner, a trailing surface or corner opposite the leading surface or corner, and trailing side surfaces adjoining the trailing surface or corner. Each pillar is oriented along a corresponding ray intersecting the leading surface or corner and the trailing surface or corner. Adjacent pillars have a turn angle between the corresponding rays of the adjacent pillars, and each pillar has a pillar angle between the trailing side surfaces thereof. The turn and pillar angles are based on a fluidic contact angle to promote fluid flow from the inlet throughout the chamber during priming without fluidic pinning.
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公开(公告)号：US20240246084A1
公开(公告)日：2024-07-25
申请号：US18559761
申请日：2021-05-10
发明人： Carson Denison , Alexander Govyadinov , Richard W. Seaver , Erik D. Torniainen , Pavel Kornilovich , Anand Samuel Jebakumar
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2300/1805 , B01L2300/1894
摘要： Apparatuses may be used for nucleic acid amplification. An example apparatus may include an amplification chamber to contain a biochemical reaction associated with amplification of a biologic sample. The biologic sample may include a nucleic acid. The apparatus may also include a heater thermally coupled to the amplification chamber. The apparatus may also include a thermally conductive substrate in contact with the heater and including a liquid coolant passage to pass a liquid coolant through the thermally conductive substrate.
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公开(公告)号：US11988594B2
公开(公告)日：2024-05-21
申请号：US18196947
申请日：2023-05-12
CPC分类号： G01N15/1484 , B01L3/50273 , H10N30/2047 , G01N2015/1006 , G01N2015/1028
摘要： An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.
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公开(公告)号：US20240033729A1
公开(公告)日：2024-02-01
申请号：US17876642
申请日：2022-07-29
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L2200/16
摘要： A reagent delivery network can include an inlet microfluidic channel, a microfluidic cross-channel branching off from the inlet microfluidic channel, a resistor positioned along the inlet microfluidic channel at a location to redirect fluid from the inlet microfluidic channel into the microfluidic cross-channel, and an outlet microfluidic channel having a side-wall opening connected to the microfluidic cross-channel. The outlet microfluidic channel can receive fluid from the microfluidic cross-channel. The microfluidic cross-channel can include a constriction region and a reagent storage chamber having reagent therein.
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公开(公告)号：US11879844B2
公开(公告)日：2024-01-23
申请号：US17417533
申请日：2019-04-30
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6454 , G01N2021/6421
摘要： An example device includes an array of sensor modules. A sensor module includes a body to be positioned in alignment with a planar target, a light source coupled to the body to emit light to the planar target along a source optical path, and a plurality of light sensors coupled to the body. Each light sensor is to sense a different wavelength of light received from the planar target along a sensor optical path. The sensor optical path is different from the source optical path. The bodies of the array of sensor modules are arranged in a planar tiling pattern with respect to a longitudinal axis of the planar target.
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公开(公告)号：US20230280263A1
公开(公告)日：2023-09-07
申请号：US18196947
申请日：2023-05-12
CPC分类号： G01N15/1484 , B01L3/50273 , H10N30/2047 , G01N2015/1006
摘要： An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels. Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.
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公开(公告)号：US20220162645A1
公开(公告)日：2022-05-26
申请号：US17414641
申请日：2019-07-25
摘要： In example implementations, an apparatus is provided. The apparatus includes a channel, a thermal inkjet (TIJ) resistor, and a transfection chamber. The TIJ resistor is to apply heat to a cell in the channel to porate the cell. The transfection chamber is to store a reagent to be inserted into the cell after the cell is porated.
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公开(公告)号：US11325380B2
公开(公告)日：2022-05-10
申请号：US16605255
申请日：2018-07-17
摘要： An example device includes a first droplet ejector including a first nozzle to eject droplets of a first fluid, and a first target medium positioned relative to the first droplet ejector to receive the droplets of the first fluid from the first droplet ejector. The example device further includes a second droplet ejector in fluid communication with the first target medium to receive a second fluid from the first target medium. The second droplet ejector includes a second nozzle to eject droplets of the second fluid.
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公开(公告)号：US11280755B2
公开(公告)日：2022-03-22
申请号：US16608322
申请日：2018-04-26
发明人： Sarah Gish , Tod Woodford , Alexander Govyadinov
IPC分类号： G01N27/327 , C25D5/02 , G01N27/30 , C23C18/42 , G01N27/333
摘要： An example device includes a processor to connect to an electrode disposed within a microfluidic volume and to connect a second electrode that includes a surface of silver metal disposed within the microfluidic volume. The processor is to apply an electrical potential between the electrode and the second electrode when the microfluidic volume contains a fluid that contains chloride ions to form a layer of silver chloride on the surface of the second electrode. The processor is further to cease application of the electrical potential and operate the second electrode as a reference electrode in a measurement process performed within the microfluidic volume.
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公开(公告)号：US11278889B2
公开(公告)日：2022-03-22
申请号：US16616944
申请日：2017-07-18
IPC分类号： B01L3/00
摘要： A sample test device is provided that includes a body having an insertion surface spaced apart from a distal end portion and a fluid manipulating assembly disposed in the distal end portion. A mixing receptacle is defined in the fluid manipulating assembly and provides a volume to mix a test mixture. A plunger is disposed in the body and creates a positive air pressure in the mixing receptacle when inserted into the body. A test die is disposed in the fluid manipulation assembly and a fluid path extends from the mixing receptacle to the test die. Activation of the plunger creates a positive pressure in the mixing receptacle to force the test mixture to flow from the mixing receptacle to the test die.
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