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公开(公告)号：US20250027966A1
公开(公告)日：2025-01-23
申请号：US18713157
申请日：2021-12-15
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Raghuvir N. Sengupta , Viktor Shkolnikov , Steven Barcelo
IPC: G01N35/10
Abstract: In accordance with the present disclosure, an example non-transitory computer readable medium may store instructions that when executed cause a computing device to dispense, using a first fluid ejector of a microfluidic device, a biologic sample to a region of a substrate, dispense, using a second fluid ejector of the microfluidic device, a reagent to the region of the substrate, and dispense, using a third fluid ejector of the microfluidic device, a metabolic indicator to the region of the substrate, wherein the metabolic indicator provides a visual indication in response to reaction with the biologic sample.
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公开(公告)号：US20250011849A1
公开(公告)日：2025-01-09
申请号：US18702182
申请日：2021-10-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Michael Cumbie , Viktor Shkolnikov
IPC: C12Q1/6844 , B01L3/00 , B01L7/00
Abstract: A digital droplet PCR system is described. The digital droplet PCR system comprises a microfluidic cartridge comprising: a plurality of sample droplet generators, wherein each sample droplet generator is operable to partition a PCR mixture into a plurality of aqueous droplets dispersed in a carrier liquid, and wherein at least one sample droplet generator is operable to partition a PCR mixture that is different to a PCR mixture that is partitioned by at least one other sample droplet generator; a thermocycling chamber comprising an embedded heater, an inlet configured to receive the plurality of aqueous droplets from the plurality of sample droplet generators, and an outlet; and an optical readout zone fluidly connected to the outlet of the thermocycling chamber; and a pressure actuated pump configured to couple to and cause fluid flow through the microfluidic cartridge. A method of performing digital droplet PCR is also described.
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公开(公告)号：US20240033740A1
公开(公告)日：2024-02-01
申请号：US17877342
申请日：2022-07-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Evan Kirshenbaum , Viktor Shkolnikov
CPC classification number: B01L3/502784 , B01L3/50273 , B01L7/52 , B01L2400/0427 , B01L2300/18
Abstract: A digital microfluidic device includes an array of controllable electrode pads alignable with a fluid passageway and a control portion. The control portion is to cause electrowetting movement of a droplet within the fluid passageway through a circuit of multiple different zones of the electrode pads. The electrowetting movement is to iteratively expose the droplet within a current zone of the different zones for a selectable current time period at a current temperature of a list of consecutive temperatures, further expose the droplet within the current zone, for each respective selectable subsequent time period, at each respective subsequent temperature of the list which is greater than the current temperature, and move the droplet into a subsequent zone of the different zones when one of the respective subsequent temperatures is less than the current temperature.
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公开(公告)号：US20230374435A1
公开(公告)日：2023-11-23
申请号：US18215105
申请日：2023-06-27
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Diane Hammerstad , Michael Cumbie
CPC classification number: C12M35/02 , C12M33/04 , C12M41/48 , C12N13/00 , C12N15/87 , C12M3/006 , C12M1/42 , A61N1/10
Abstract: An electroporation system may include a well plate, a dispenser and a dispenser-well positioning system. The well plate may include wells, each of the wells including an interior, a first electrode adjacent the interior and a second electrode adjacent the interior and spaced from the first electrode. The first electrode and the second electrode are to apply an electrostatic field across the well. The dispenser is to dispense a cell having a diameter into each of the wells. The dispenser-well positioning system is to align each well and the dispenser such that the dispenser dispenses the cell into each well at a location spaced from the first electrode and the second electrode by a distance of at least 5 times the diameter of the cell.
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公开(公告)号：US20230250378A1
公开(公告)日：2023-08-10
申请号：US18012613
申请日：2020-07-08
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Alexander N. Govyadinov
CPC classification number: C12M23/16 , C12M35/04 , C12M41/40 , G01N15/1463 , G01N15/1459 , G01N2015/1495 , G01N2015/1006
Abstract: An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
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Patent Agency Ranking
公开(公告)号：US20230241609A1
公开(公告)日：2023-08-03
申请号：US18010794
申请日：2020-06-17
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeffrey A. Nielsen , Viktor Shkolnikov , Erica Squires , Roberto A. Pugliese , Matthew D. Smith , Michael J. Day , Diane R. Hammerstad
CPC classification number: B01L3/502746 , G01N15/1031 , G01N15/1056 , B01L2300/0663 , B01L2400/08 , B01L2200/061 , B01L2200/027 , B01L2300/0867 , B01L2200/0647
Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.
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公开(公告)号：US11673107B2
公开(公告)日：2023-06-13
申请号：US16606368
申请日：2018-05-01
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Chien-Hua Chen
CPC classification number: B01J13/02 , B01L3/50273 , B01L3/502784 , B01L2200/0621 , B01L2300/0867 , B01L2400/0487
Abstract: An example system includes a primary channel having a first end and a second end, at least two reagent reservoirs coupled to the first end, and a controller. Each reservoir contains a reagent in a fluid solution and is associated with an integrated pump to drive a reagent droplet from the corresponding reagent reservoir into the primary channel towards the second end. The controller is coupled to the integrated pumps and operates according to a sequence to actuate the integrated pumps, the sequence being indicative of reagents in the reagent reservoirs. The actuation of the pumps is to drive the reagent droplets from the reagent reservoirs into the primary channel in accordance with the sequence. The example system also includes a shell material reservoir with a shell material and an associated shell material pump to drive the shell material into the primary channel to encapsulate the reagent droplets.
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公开(公告)号：US11441960B2
公开(公告)日：2022-09-13
申请号：US16074349
申请日：2016-04-20
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Ning Ge , Alexander Govyadinov , Anita Rogacs , Viktor Shkolnikov
Abstract: A microfluidic pressure sensor may include a reference chamber, a sensed volume, a microfluidic channel connecting an interior of the reference chamber to an interior of the sensed volume, a volume of liquid contained and movable within the microfluidic channel while occluding the microfluidic channel and a sensor to output signals indicating positioning of the volume of liquid along the microfluidic channel. Positioning of the volume of liquid along microfluidic channel indicates a pressure of the sensed volume.
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公开(公告)号：US20220250077A1
公开(公告)日：2022-08-11
申请号：US17611287
申请日：2019-07-24
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Michael W. Cumbie , Viktor Shkolnikov , Chien-Hua Chen
Abstract: An example digital microfluidics device includes a device body having a primary substrate defining a planar primary substrate surface; a plurality of droplet processing components having respective component substrates overmolded in the primary substrate in a coplanar arrangement with the primary substrate surface; and an electrical interface carried on the primary substrate surface, the electrical interface defining a planar droplet manipulation surface and carrying a set of droplet manipulation electrodes adjacent to the droplet manipulation surface; the electrical interface configured to interconnect the droplet manipulation electrodes and at least a portion of the droplet processing components.
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公开(公告)号：US11325125B2
公开(公告)日：2022-05-10
申请号：US16076074
申请日：2017-04-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Chien-Hua Chen
Abstract: A fluid entrained particle separator may include an inlet passage to direct particles entrained in a fluid, a first separation passage branching from the inlet passage, a second separation passage branching from the inlet passage and electrodes to create electric field exerting a dielectrophoretic force on the particles to direct the particles to the first separation passage or the second separation passage, wherein the first separation passage, the second separation passage, the electric field and the dielectrophoretic force extend in a plane.
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