公开(公告)号：US20070292357A1

公开(公告)日：2007-12-20

申请号：US11880007

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K31/445 ,  A61K31/56 ,  A61K9/12 ,  A61P11/00 ,  A61P11/08

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20070292356A1

公开(公告)日：2007-12-20

申请号：US11880002

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K31/445 ,  A61K31/56 ,  A61K9/12 ,  A61P11/00

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US20070265305A1

公开(公告)日：2007-11-15

申请号：US11879996

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Craig Husfeld ,  Li Li

IPC: A61K31/445 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08

CPC classification number: C07D211/62 ,  A61K9/124 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US07262205B2

公开(公告)日：2007-08-28

申请号：US11077345

申请日：2005-03-10

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Eric L. Stangeland ,  Aaron Kushner ,  Craig Husfeld

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Eric L. Stangeland ,  Aaron Kushner ,  Craig Husfeld

IPC: A61K31/445 ,  C07D211/04 ,  C07D401/12

CPC classification number: C07D211/62 ,  C07D211/60

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：US07208515B2

公开(公告)日：2007-04-24

申请号：US11543622

申请日：2006-10-05

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

IPC: A61K31/40 ,  C07D207/09

CPC classification number: C07D403/12 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/40 ,  A61K31/445 ,  C07D207/09

Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供了式I化合物：其中a，b，c，e，m，R 1，R 2，R 3，R R 4a，R 4b，R 5，R 6，R 7和/或R 4， R 8如本说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20070078163A1

公开(公告)日：2007-04-05

申请号：US11602802

申请日：2006-11-21

Applicant: Mathai Mammen ,  Adam Hughes ,  Yu-hua Ji ,  Li Li ,  Weijiang Zhang

Inventor： Mathai Mammen ,  Adam Hughes ,  Yu-hua Ji ,  Li Li ,  Weijiang Zhang

IPC: A61K31/445 ,  A61K31/40 ,  C07D211/26 ,  C07D207/30 ,  C07C269/02

CPC classification number: C07D207/08 ,  A61K31/40 ,  C07D207/09 ,  C07D207/16 ,  C07D211/34

Abstract: This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors using such compounds.

公开(公告)号：US20070032524A1

公开(公告)日：2007-02-08

申请号：US11543622

申请日：2006-10-05

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  Sarah Dunham ,  Li Li

IPC: A61K31/445 ,  A61K31/40 ,  C07D211/26 ,  C07D207/30

CPC classification number: C07D403/12 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/40 ,  A61K31/445 ,  C07D207/09

Abstract: This invention provides compounds of formula I: wherein a, b, c, e, m, R1, R2, R3, R4a, R4b, R5, R6, R7 and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供了式I化合物：其中a，b，c，e，m，R 1，R 2，R 3，R R 4a，R 4b，R 5，R 6，R 7和R 7，R 7， 在说明书中定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20060229334A1

公开(公告)日：2006-10-12

申请号：US11449004

申请日：2006-06-07

Applicant: Mathai Mammen ,  Adam Hughes ,  Yan Chen

Inventor： Mathai Mammen ,  Adam Hughes ,  Yan Chen

IPC: A61K31/4709 ,  A61K31/445 ,  C07D401/02 ,  C07D211/54

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I的联苯衍生物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，W，a，b和c如说明书中所定义，或其药学上可接受的盐或 其溶剂合物或立体异构体。 本发明的联苯衍生物具有β2N2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺病和哮喘。

公开(公告)号：US20060205779A1

公开(公告)日：2006-09-14

申请号：US11372294

申请日：2006-03-09

Applicant: YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Eric Stangeland

Inventor： YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Eric Stangeland

IPC: A61K31/445 ,  C07D211/54 ,  C07D211/40

CPC classification number: C07D211/46 ,  C07D405/12

Abstract: The invention provides compounds of formula I: wherein a, b, c, p, W, A, X1, R1, R2, R3, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，p，W，A，X 1，R 1，R 2， R 3，R 6，R 7和R 8如本说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20060205775A1

公开(公告)日：2006-09-14

申请号：US11371512

申请日：2006-03-09

Applicant: Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

Inventor： Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

IPC: A61K31/4545 ,  A61K31/454 ,  C07D401/02 ,  C07D403/02

CPC classification number: C07D405/14 ,  C07D211/62 ,  C07D401/12 ,  C07D409/14

Abstract: The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 7，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。