公开(公告)号：US20140308294A1

公开(公告)日：2014-10-16

申请号：US14110173

申请日：2012-04-13

Applicant: Anita Seshire ,  Michael Wolf ,  Robert Tighe ,  Helen Sabzevari

Inventor： Anita Seshire ,  Michael Wolf ,  Robert Tighe ,  Helen Sabzevari

IPC: C07K16/28 ,  C07K14/715 ,  G01N33/574 ,  C07K16/30

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K14/7155 ,  C07K16/245 ,  C07K16/30 ,  C07K2317/76 ,  G01N33/57492

Abstract: The invention relates to polypeptides that block or inhibit the interleukin-1 receptor 1 (IL-1R1), the interaction of IL-1beta with IL-1R1 or the interaction between IL-1R1 and interleukin-1 receptor accessory protein (IL-1RaCP). The invention relates specifically to therapeutic polypeptides that target specifically IL-1R1 present on tumor cells, cancer stem cells, and cancer stem cells which are resistant to chemotherapy or radiotherapy. The invention specifically relates to cancer stem cells (CSC) that express IL-1R1 to which said inhibitors bind. Finally the invention relates to a combination therapy comprising killing tumorigenic differentiating cancer cells by means of standard chemo- or radiotherapy and prior or subsequent to that applying IL-1R1 inhibitors which target specifically CSC and strip the tumor of its capacity to generate cancer cell progeny.

Abstract translation: 本发明涉及阻断或抑制白细胞介素-1受体1（IL-1R1），IL-1β与IL-1R1的相互作用或IL-1R1与白细胞介素-1受体辅助蛋白（IL-1RaCP）相互作用的多肽， 。 本发明具体涉及特异性靶向肿瘤细胞上的IL-1R1的治疗性多肽，癌症干细胞和对化学疗法或放射疗法有抗性的癌症干细胞。 本发明具体涉及表达所述抑制剂结合的IL-1R1的癌干细胞（CSC）。 最后，本发明涉及包括通过标准化疗或放疗杀死致瘤性分化癌细胞的组合疗法，并且在施用特异性CSC并分离其产生癌细胞后代的肿瘤的IL-1R1抑制剂之前或之后。

公开(公告)号：US20130341329A1

公开(公告)日：2013-12-26

申请号：US13389991

申请日：2011-12-08

Applicant: Deborah Adler ,  Duane Sawyer ,  Michael Wolf ,  Joshua Stewart ,  Yayun Huang

Inventor： Deborah Adler ,  Duane Sawyer ,  Michael Wolf ,  Joshua Stewart ,  Yayun Huang

IPC: B65D85/00

CPC classification number: G06Q10/087 ,  A61J1/03 ,  A61J7/04 ,  A61J2205/30 ,  A61J2205/50 ,  B65D1/0223 ,  B65D41/0471 ,  B65D50/046 ,  B65D85/00 ,  B65D2501/0081 ,  G09F3/02 ,  G09F3/0288 ,  G09F3/0289 ,  G09F3/10 ,  G09F2003/0272

Abstract: The present invention relates to systems, methods, and apparatuses for the management, distribution, dispensing, and administration of consumer products, including over-the-counter and prescription medications through use of a product container labeling system and an optional integrated computer-based or online management system. In certain aspects, the invention relates to a product container comprising a hollow body, a child-resistant cap, and a specialized information label affixed to the hollow body.

Abstract translation: 本发明涉及用于通过使用产品容器标签系统和可选的集成的计算机或可选集成的标签系统来管理，分发，分配和管理消费品的系统，方法和装置，包括非处方药和处方药 在线管理系统。 在某些方面，本发明涉及一种产品容器，其包括中空体，防儿童帽和固定在中空体上的专门信息标签。

公开(公告)号：US08490076B2

公开(公告)日：2013-07-16

申请号：US11770393

申请日：2007-06-28

Applicant: Michael Wolf ,  Matthias Roth ,  Gerhard Scholand ,  Achim Recksiek

Inventor： Michael Wolf ,  Matthias Roth ,  Gerhard Scholand ,  Achim Recksiek

IPC: G06F9/44

CPC classification number: G06F17/30106 ,  G06F8/71

Abstract: A method and system for collecting installed application data from a computer system. The method includes scanning a file system of the computer system to produce file system data, and scanning an installed application database of the computer system to produce installed application data. The method further includes collecting system information associated with the computer system. The method still further includes combining the file system data, the application data, and the system information to produce an output file.

Abstract translation: 一种用于从计算机系统收集安装的应用数据的方法和系统。 该方法包括扫描计算机系统的文件系统以产生文件系统数据，以及扫描计算机系统的安装的应用数据库以产生安装的应用数据。 该方法还包括收集与计算机系统相关联的系统信息。 该方法还包括组合文件系统数据，应用程序数据和系统信息以产生输出文件。

公开(公告)号：US08119795B2

公开(公告)日：2012-02-21

申请号：US12301140

申请日：2007-04-20

Applicant: Hans-Michael Eggenweiler ,  Michael Wolf ,  Hans-Peter Buchstaller ,  Christian Sirrenberg

Inventor： Hans-Michael Eggenweiler ,  Michael Wolf ,  Hans-Peter Buchstaller ,  Christian Sirrenberg

IPC: A61K31/4196 ,  C07D503/12 ,  C07D249/12 ,  C07D401/12

CPC classification number: C07D249/08 ,  C07D401/12 ,  C07D403/12

Abstract: Novel triazole derivatives of the formula (I) in which R1-R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract translation: 式（I）的新型三唑衍生物，其中R 1 -R 6和Y具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和/ 或调制HSP90起作用。

公开(公告)号：US20110254499A1

公开(公告)日：2011-10-20

申请号：US12308585

申请日：2007-05-23

Applicant: Michael Wolf ,  Marcus Bremmer

Inventor： Michael Wolf ,  Marcus Bremmer

IPC: H02J7/04 ,  H02J7/00

CPC classification number: H02J7/0016

Abstract: A device for charging a battery system having a number of individual voltage sources situated in a series circuit is provided, which device uses a voltage source and a respective bypass associated with each of the individual voltage sources. A charge current IL is supplied from the voltage source via the bypasses to the individual voltage sources as a function of their charge condition.

Abstract translation: 提供了一种用于为具有位于串联电路中的多个单独电压源的电池系统进行充电的装置，该装置使用与各个电压源相关联的电压源和相应的旁路。 充电电流IL从电压源通过旁路提供给各个电压源，作为其充电条件的函数。

公开(公告)号：US07977343B2

公开(公告)日：2011-07-12

申请号：US12063384

申请日：2006-07-20

Applicant: Hans-Peter Buchstaller ,  Hans-Michael Eggenweiler ,  Bertram Cezanne ,  Michael Wolf

Inventor： Hans-Peter Buchstaller ,  Hans-Michael Eggenweiler ,  Bertram Cezanne ,  Michael Wolf

IPC: A61K31/535

CPC classification number: C07D473/34

Abstract: Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract translation: 式（I）的新型腺嘌呤衍生物，其中R 1，R 2，R 3，X和Y具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。

公开(公告)号：US07950418B2

公开(公告)日：2011-05-31

申请号：US12711765

申请日：2010-02-24

Applicant: Michael Wolf ,  Manfred Peschka

Inventor： Michael Wolf ,  Manfred Peschka

IPC: F16L55/16

CPC classification number: F16L55/1683

Abstract: A method for repairing a pipeline by means of at least one shell that is adapted to the outer contour of the pipeline, wherein the at least one shell is attached to the outer wall of the pipeline using an intermediate layer between the interior of the shell and the outer wall of the pipeline. The intermediate layer is made of an adhesive that can be activated, which is used to substantially completely coat the interior of the at least one shell. The attachment of the shell is carried out by applying a force acting at least in the radial direction, and the activation of the adhesive. A shell that is coated in this manner is also disclosed.

Abstract translation: 一种用于通过至少一个适于管道外轮廓的外壳修复管道的方法，其中至少一个壳体使用在壳体的内部和内部之间的中间层连接到管道的外壁上 管道的外壁。 中间层由可以被活化的粘合剂制成，其用于基本上完全涂覆至少一个壳体的内部。 通过施加至少沿径向作用的力和粘合剂的活化来进行外壳的附接。 也公开了以这种方式涂覆的外壳。

公开(公告)号：US07947696B2

公开(公告)日：2011-05-24

申请号：US11914604

申请日：2006-04-24

Applicant: Hans-Michael Eggenweiler ,  Michael Wolf ,  Hans-Peter Buchstaller

Inventor： Hans-Michael Eggenweiler ,  Michael Wolf ,  Hans-Peter Buchstaller

IPC: A61K31/517

CPC classification number: C07D401/12 ,  C07D239/84 ,  C07D403/12

Abstract: Novel phenylquinazoline derivatives of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract translation: 式（I）的新的苯基喹唑啉衍生物，其中R 1，R 2，R 3，R 4和R 5具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。

公开(公告)号：US20110028485A1

公开(公告)日：2011-02-03

申请号：US12883428

申请日：2010-09-16

Applicant: Hans-Michael EGGENWEILER ,  Michael Wolf ,  Hans-Peter Buchstaller ,  Christian Sirrenberg

Inventor： Hans-Michael EGGENWEILER ,  Michael Wolf ,  Hans-Peter Buchstaller ,  Christian Sirrenberg

IPC: A61K31/415 ,  C07D231/12 ,  C07D403/12 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/501 ,  A61K31/497 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P31/00 ,  A61P9/10 ,  A61P31/12 ,  A61P3/10 ,  A61P11/06 ,  A61P17/06 ,  A61P25/00 ,  A61P1/00

CPC classification number: C07D231/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract translation: 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节 和/或调节HSP90起作用。

公开(公告)号：US20100126920A1

公开(公告)日：2010-05-27

申请号：US12522495

申请日：2008-01-11

Applicant: Sonia Lorente ,  Michael Wolf ,  Guenter Jokschas ,  Horst Croissant

Inventor： Sonia Lorente ,  Michael Wolf ,  Guenter Jokschas ,  Horst Croissant

IPC: B01D17/12

CPC classification number: B01D27/148 ,  B01D36/001 ,  Y10S210/17

Abstract: The invention concerns a fuel filter 10, in particular for diesel fuels, that comprises a housing 11 and a filter medium 12. The filter medium 12 is arranged by means of a filter medium holder 24 in the housing, wherein the filter medium holder comprises a venting bore 25. Through the venting bore 25 gases that collect in the upper area of the fuel filter can pass from the crude chamber 21 into the clean chamber 22. For avoiding that contaminants can escape through a clean outlet 18 from the fuel filter 10 and damage components downstream, a clean medium 26 is provided that retains such contaminants.

Abstract translation: 本发明涉及一种燃料过滤器10，特别是用于柴油燃料的燃料过滤器10，其包括壳体11和过滤介质12.过滤介质12通过过滤介质保持器24布置在壳体中，其中过滤介质保持器包括 通过排气孔25收集在燃料过滤器的上部区域中的气体可以从粗制室21进入清洁室22.为了避免污染物通过清洁的出口18从燃料过滤器10排出，以及 在下游损坏部件，提供保持这种污染物的清洁介质26。