公开(公告)号：US5899935A

公开(公告)日：1999-05-04

申请号：US905704

申请日：1997-08-04

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/00 ,  A61F2/90 ,  A61L31/08 ,  A61L31/10 ,  A61F2/06 ,  A61F2/04

CPC classification number: A61F2/90 ,  A61L31/084 ,  A61L31/10 ,  A61F2/0077 ,  Y10T29/49888 ,  Y10T29/49982 ,  Y10T29/49986

Abstract: A method of making a balloon expandable braided stent with a restraint to initially prevent self-expansion and the resulting product. Multiple strands of a resilient metal or plastic are braided to form a tubular configuration of a predetermined outside diameter which assumes a lesser diameter when the tubular stent is longitudinally stretched. When in its stretched condition, it is coated with a polymeric material which is then cross-linked to effectively "freeze" the intersections of the braided structure holding it in its reduced diameter configuration. The tubular stent is designed to be placed within a body vessel using a balloon stent delivery catheter. When the balloon surrounded by the braided wire stent is inflated, the stent expands initially to an extent to break the bonds of plastic material between the intersections of the strands, thereby permitting self-expansion to take place. The coating may also comprise a hydrogel or an elastomeric impregnated with the water soluble particles which softens and/or deteriorates upon exposure to an aqueous media, such as blood.

Abstract translation: 制造具有约束力的球囊可扩张编织支架的方法，以最初防止自膨胀和所得产品。 编织弹性金属或塑料的多股线以形成具有预定外径的管状构造，当管状支架纵向拉伸时呈现较小的直径。 当处于拉伸状态时，其被涂覆有聚合材料，然后将其交联以有效地“冻结”其缩小直径构型的编织结构的交叉点。 管状支架被设计成使用球囊支架输送导管放置在体内容器内。 当由编织线支架包围的气囊膨胀时，支架首先膨胀到一定程度，以破坏在股线的交叉点之间的塑性材料的接合，从而允许发生自膨胀。 涂层还可以包含水凝胶或浸渍有水溶性颗粒的弹性体，其在暴露于含水介质如血液时会软化和/或劣化。

公开(公告)号：US5576072A

公开(公告)日：1996-11-19

申请号：US382459

申请日：1995-02-01

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/04 ,  A61L29/08 ,  B05D7/00 ,  B05D7/02 ,  C08G18/10 ,  C08G18/48 ,  C08G18/75 ,  C09D175/04 ,  B05D3/00 ,  B29C71/02 ,  C04B41/00 ,  H05H1/00

CPC classification number: B05D7/54 ,  A61L29/049 ,  A61L29/085 ,  B05D7/02 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/755 ,  C08G18/758 ,  C09D175/04 ,  C08G2210/00 ,  Y10T428/31551

Abstract: A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。