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    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
    7.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel 失效
    含有聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法，该水凝胶与至少一种其它不同的聚合物水凝胶

    公开(公告)号：US5576072A

    公开(公告)日：1996-11-19

    申请号：US382459

    申请日：1995-02-01

    申请人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/04 ,  A61L29/08 ,  B05D7/00 ,  B05D7/02 ,  C08G18/10 ,  C08G18/48 ,  C08G18/75 ,  C09D175/04 ,  B05D3/00 ,  B29C71/02 ,  C04B41/00 ,  H05H1/00

    CPC分类号： B05D7/54 ,  A61L29/049 ,  A61L29/085 ,  B05D7/02 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/755 ,  C08G18/758 ,  C09D175/04 ,  C08G2210/00 ,  Y10T428/31551

    摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    摘要翻译： 制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel
    9.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel 失效
    含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶的聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法

    公开(公告)号：US5662960A

    公开(公告)日：1997-09-02

    申请号：US384711

    申请日：1995-02-01

    申请人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08J7/00 ,  C08J7/04 ,  B05D3/10 ,  B05D3/04 ,  C23C14/02

    CPC分类号： B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G2210/00 ,  C08G2270/00

    摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    摘要翻译： 一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

    Process for hydrophilicization of hydrophobic polymers
    10.
    发明授权
    Process for hydrophilicization of hydrophobic polymers 失效
    疏水聚合物亲水化方法

    公开(公告)号：US5849368A

    公开(公告)日：1998-12-15

    申请号：US851052

    申请日：1997-05-05

    申请人： Fritz Hostettler ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/00 ,  A61L31/00 ,  C08F8/06 ,  C08F8/30 ,  C08J3/28 ,  C08J7/00 ,  C08J7/04 ,  C08J7/12 ,  B05D3/00 ,  C23C16/00 ,  H05H1/00

    CPC分类号： C08J7/123 ,  C08J7/04 ,  C08J7/047 ,  C08J7/12 ,  C08J2315/00 ,  C08J2475/00

    摘要： A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed. The process involves dual plasma-treatment of a polymeric plastic or rubber substrate material; the first treatment being with an oxygen-containing plasma gas, to affix hydroxyl, carboxyl and carbonyl groups to the substrate surface, thereby rendering the surface more polar and activated; and the second treatment being with a nitrogen-containing plasma gas, to affix amine and amino groups to the substrate surface to make it more hydrophilic and reactive toward terminal isocyanate groups of a polyurethane or polyurethane/urea prepolymer adduct intermediate tie-coat which is subsequently applied to the substrate surface and then converted to a tenaciously adhering, slippery hydrogel coating. The process is especially suited to the hydrophilicization of intrinsically non-polar and hydrophobic polymeric plastic materials, such as polyethylenes, nylons-11 and nylons-12.

    摘要翻译： 使本体非极性或仅极微小的聚合物塑料或橡胶材料表面的方法，以及疏水，极性或更极性和亲水性的方法，使得含胺官能团，最终持久坚固地粘附 ，可以随后将湿滑的聚氨酯或聚氨酯 - 尿素水凝胶涂层施加到聚合物表面。 该方法涉及聚合物塑料或橡胶基材材料的双等离子体处理; 用含氧等离子体气体进行第一次处理，将羟基，羧基和羰基粘合到基材表面，从而使表面更加极性和活化; 并且第二次处理是用含氮等离子体气体，以将胺和氨基固定在基材表面上，使其对聚氨酯或聚氨酯/脲预聚物加合物中间粘结层的末端异氰酸酯基团更亲水并具有反应性 施加到基材表面，然后转化成坚固粘附，滑滑的水凝胶涂层。 该方法特别适用于本征非极性和疏水性聚合物塑料材料如聚乙烯，尼龙-11和尼龙-12的亲水化。