公开(公告)号：US07571728B2

公开(公告)日：2009-08-11

申请号：US10820433

申请日：2004-04-08

Applicant: Michael R. Forman ,  Darius Francescatti

Inventor： Michael R. Forman ,  Darius Francescatti

IPC: A61B19/00

CPC classification number: A61B10/0041 ,  A61B6/502 ,  A61B2090/3908

Abstract: A system and method to position and orient an excised breast tissue specimen on a support structure in a duplicate anatomic orientation relative to the operated breast is provided. One embodiment of the system includes an anatomically representative map of the breast under investigation. The system allows a surgeon to suture, ink, or otherwise fix the excised specimen on the map in accordance to its original position and orientation in the operated breast or organ. A radiogram of the excised specimen can be taken that shows the location of calcifications on a grid with radiopaque markers. The system allows a pathologist to cut through the specimen utilizing the map as a template in order to perform histological analysis and correlate the position and orientation of each slice to its anatomic position in the breast and thereby direct a precise and anatomically accurate re-excision by the surgeon if so required.

Abstract translation: 提供了一种系统和方法，用于将切除的乳房组织样本定位和定向在相对于被操作的乳房的重复解剖方向的支撑结构上。 该系统的一个实施例包括正在调查的乳房的解剖学代表性的地图。 该系统允许外科医生根据其在操作的乳房或器官中的原始位置和取向缝合，油墨或以其他方式将切除的样本固定在地图上。 可以采取切除标本的放射线图，显示在具有不透射线标记的网格上钙化的位置。 该系统允许病理学家通过使用地图作为模板切割样本，以便进行组织学分析，并将每个切片的位置和取向与其在乳房中的解剖位置相关联，从而通过以下方式指导精确和解剖学上准确的再切除 外科医生如果需要的话。

公开(公告)号：US07041046B2

公开(公告)日：2006-05-09

申请号：US09850728

申请日：2001-05-07

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61N5/00

CPC classification number: A61K51/1282 ,  A61M25/002 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1097 ,  A61N5/1001 ,  A61N2005/1003 ,  A61N2005/1004

Abstract: The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled immunomodulator delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and immunomodulator delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an immunomodulator to the body lumen.

Abstract translation: 本发明提供用于在血管内干预后抑制再狭窄和增生的改进的装置，方法和试剂盒。 特别地，本发明提供与电离辐射组合的受控免疫调节剂递送至患者脉管系统内的选定位置，以减少和/或抑制再狭窄和增生率与增加的功效。 在一个实施方案中，用于抑制增生的组合辐射和免疫调节剂递送导管包括具有近端和远端的导管主体，可耦合到导管主体的用于将辐射剂量施加到体腔的电离辐射源，以及多孔材料， 基质，膜，屏障，涂层，输液腔，支架，移植物或储存器，用于将免疫调节剂释放到体腔。

公开(公告)号：US06390967B1

公开(公告)日：2002-05-21

申请号：US09661438

申请日：2000-09-14

Applicant: Michael R. Forman ,  Paul A. Lovoi ,  Tom W. Rusch

Inventor： Michael R. Forman ,  Paul A. Lovoi ,  Tom W. Rusch

IPC: A61N500

CPC classification number: A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1021

Abstract: Apparatus and methods are provided for applying a radially uniform radiation dose to an intravascular treatment region to inhibit hyperplanes, and specifically to reduce “candy-wrapper” ends, following intravascular intervention. An embodiment of the apparatus comprises a catheter body having a proximal end and a distal end, a pair of axially spaced apart radiation shields on the catheter body, and a radiation source. The radiation source applies a radiation dose which is substantially uniform in a radial direction over an entire distance between the axially spaced apart shields.

Abstract translation: 提供了设备和方法，用于将径向均匀的辐射剂量施加到血管内治疗区域以抑制超平面，并且具体地减少血管内干预后的“糖果包裹物”端。 该装置的实施例包括具有近端和远端的导管主体，导管主体上的一对轴向隔开的辐射屏蔽和辐射源。 辐射源施加辐射剂量，其在轴向间隔开的屏蔽之间的整个距离处在径向方向上基本均匀。

公开(公告)号：US06280413B1

公开(公告)日：2001-08-28

申请号：US08889432

申请日：1997-07-08

Applicant: David W. Clark ,  Souise S. Clark ,  Victor I. Chornenky ,  Michael R. Forman ,  Jeffrey A. Lee

Inventor： David W. Clark ,  Souise S. Clark ,  Victor I. Chornenky ,  Michael R. Forman ,  Jeffrey A. Lee

IPC: A61M2900

CPC classification number: A61M25/0082 ,  A61F2/013 ,  A61F2230/0006 ,  A61F2230/005 ,  A61M25/0071 ,  A61M25/0074 ,  A61M2025/0057

Abstract: A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.

Abstract translation: 公开了溶栓过滤和药物递送导管，其包括纵轴的轴。 肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。 例如，可以通过套筒或螺纹将肋压缩。 药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。 优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

公开(公告)号：US6129704A

公开(公告)日：2000-10-10

申请号：US25094

申请日：1998-02-17

Applicant: Michael R. Forman ,  Jonathan S. Stinson ,  Michael N. Helmus

Inventor： Michael R. Forman ,  Jonathan S. Stinson ,  Michael N. Helmus

IPC: A61B17/00 ,  A61M1/10 ,  A61M1/12 ,  A61M25/00 ,  A61M29/02 ,  A61M29/00 ,  A61M1/00

CPC classification number: A61M25/104 ,  A61M1/101 ,  A61M1/1036 ,  A61M1/125 ,  A61M25/00 ,  A61M29/02 ,  A61B2017/00685 ,  A61M1/127 ,  A61M2025/1095

Abstract: A balloon catheter having a perfusion lumen communicating with a blood vessel, and a magnetically driven impeller disposed in the perfusion lumen to increase blood flow through the catheter and the arteries.

Abstract translation: 具有与血管连通的灌注腔的气囊导管和设置在灌注腔内的磁驱动叶轮以增加通过导管和动脉的血流。

公开(公告)号：US06017577A

公开(公告)日：2000-01-25

申请号：US382478

申请日：1995-02-01

Applicant: Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

Inventor： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

IPC: A61L29/08 ,  A61L31/10 ,  C08G18/10 ,  C08G18/28 ,  C08J7/04 ,  B05D3/06 ,  B05D1/36

CPC classification number: C08J7/047 ,  A61L29/085 ,  A61L31/10 ,  C08G18/10 ,  C08G18/283 ,  C08J7/04 ,  C08G2230/00 ,  C08J2475/00 ,  Y10T428/31554 ,  Y10T428/31562 ,  Y10T428/31565 ,  Y10T428/31569 ,  Y10T428/31587 ,  Y10T428/31678

Abstract: A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

Abstract translation: 用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材 ，被披露。 涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。 涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。 水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

公开(公告)号：US5925016A

公开(公告)日：1999-07-20

申请号：US534856

申请日：1995-09-27

Applicant: Victor I. Chornenky ,  Michael R. Forman

Inventor： Victor I. Chornenky ,  Michael R. Forman

IPC: A61F2/958 ,  A61M25/00 ,  A61M29/00

CPC classification number: A61M25/09 ,  A61M25/10 ,  A61M2025/0047 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/1052 ,  A61M2205/36 ,  A61M25/007 ,  A61M25/1011

Abstract: Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.

Abstract translation: 公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。 该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管 血栓在压力下。 优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。 管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。 然后将过滤的药物或溶解剂再次送入远端区域。 以这种方式回收药物或溶解剂降低了程序的成本。 本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

公开(公告)号：US5826588A

公开(公告)日：1998-10-27

申请号：US956963

申请日：1997-10-23

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61M29/02 ,  A61B19/00 ,  A61M29/00

CPC classification number: A61M25/1029 ,  A61M25/104 ,  A61M2025/1031

Abstract: A dilatation balloon (20,98) is fabricated according to a process that yields high hoop strength and uniformity in balloon wall thickness. A length of tubing (34) is axially elongated and radially expanded in a form (36) to provide the requisite biaxial orientation and strength. Then, an excimer laser (46,66,84) is used to remove the polymeric material by photo-chemical ablation, virtually without thermal effects. Dilatation balloon walls are thinned primarily along tapered sections (26,28) between proximal and distal balloon stems (30,32) and a medial working section (24) of the balloon. Material removal, particularly near the balloon stems, enables tighter wrapping of the balloon for a reduced delivery profile, and reduces rigidity near the stems for better maneuverability of the catheter in tortuous passageways. The balloon tapered sections are reduced to a wall thickness substantially equal to that of the medial section. Alternatively, an array of grooves (96) is formed in each tapered section.

Abstract translation: 膨胀球囊（20,98）根据产生高气球强度和球囊壁厚度均匀性的方法制造。 一段长度的管道（34）轴向地伸长并以（36）的形式径向扩张，以提供所需的双轴取向和强度。 然后，准分子激光器（46,66,84）用于通过光学化学消融去除聚合物材料，实际上没有热效应。 扩张球囊壁主要在近端和远端气囊杆（30,32）和球囊的内侧工作部分（24）之间的锥形部分（26,28）上变薄。 特别是气囊杆附近的材料去除使得球囊能够更紧密地包裹以减少输送轮廓，并且降低杆附近的刚度，从而更好地操纵导管在曲折通道中的机动性。 气囊锥形部分被还原成基本上等于中间部分的壁厚。 或者，在每个锥形部分中形成有凹槽阵列（96）。

公开(公告)号：US5713853A

公开(公告)日：1998-02-03

申请号：US488216

申请日：1995-06-07

Applicant: David W. Clark ,  Souise S. Clark ,  Michael R. Forman

Inventor： David W. Clark ,  Souise S. Clark ,  Michael R. Forman

IPC: A61B17/22 ,  A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M31/00

CPC classification number: A61M25/007 ,  A61M29/02 ,  A61B2017/22082 ,  A61M2025/105 ,  A61M25/10

Abstract: A catheter for delivering drugs or other agents is disclosed particularly suited for delivering drugs proximate the walls of a vessel or lumen, such as an artery or vein. The catheter comprises a shaft with a distal portion comprising at least one and preferably a plurality of delivery members. When deployed, the delivery members flare from the catheter shaft at an acute or obtuse angle. At least a portion of the delivery members are within a restraining member such as a sleeve or thread, for example, to maintain the delivery member within the diameter of the shaft prior to deployment. Delivery lumens provide drugs to ports in the delivery members for delivery out of the catheter. The delivery members preferably bear against the wall of the vessel when deployed, to deliver the drug or other agent proximate the walls of the blood vessel, where blood flow is slow. In another embodiment the delivery members comprise a first tapered portion, a second longitudinal portion and a plurality of drug delivery ports.

Abstract translation: 公开了用于递送药物或其它药剂的导管，其特别适合于在血管或内腔（例如动脉或静脉）的壁附近输送药物。 导管包括具有远端部分的轴，该远侧部分包括至少一个且优选地多个递送构件。 当展开时，输送构件以尖锐或钝角从导管轴上扩张。 输送构件的至少一部分在诸如套筒或螺纹的限制构件内，例如在展开之前将输送构件保持在轴的直径内。 输送流体向输送部件中的端口提供药物以从导管输送。 递送构件优选在展开时抵靠血管的壁，以在血液流动缓慢的血管壁附近递送药物或其它药剂。 在另一个实施例中，递送构件包括第一锥形部分，第二纵向部分和多个药物输送端口。

公开(公告)号：US5415636A

公开(公告)日：1995-05-16

申请号：US227254

申请日：1994-04-13

Applicant: Michael R. Forman

Inventor： Michael R. Forman

IPC: A61M25/00 ,  A61F2/82 ,  A61M25/10 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/104 ,  A61M2025/0175 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61M25/1006

Abstract: A dilation-drug delivery catheter comprises a dilation portion for dilating a stenosis and a drug delivery portion for delivering antithrombolytic, antiproliferative, or any other type of medication, to the dilation site. The drug delivery portion of the catheter is located within the dilation portion, which can be retracted to reveal the drug delivery portion, after dilation. Occlusion balloons are preferably provided on the drug delivery portion to isolate the dilation site during drug delivery.

Abstract translation: 扩张药物递送导管包括用于扩张狭窄的扩张部分和用于将抗血栓溶解，抗增殖或任何其它类型的药物递送至扩张部位的药物递送部分。 导管的药物输送部分位于扩张部分内，其可以在扩张后缩回以露出药物输送部分。 阻塞气囊优选地设置在药物递送部分上以在药物递送期间分离扩张部位。