公开(公告)号：US11355328B2

公开(公告)日：2022-06-07

申请号：US16073993

申请日：2017-04-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00 ,  H01J49/42

Abstract: The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap.

公开(公告)号：US11348778B2

公开(公告)日：2022-05-31

申请号：US15772738

申请日：2016-11-02

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Christopher Pulliam

IPC: H01J49/42 ,  H01J49/00

Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.

公开(公告)号：US11289321B2

公开(公告)日：2022-03-29

申请号：US17070411

申请日：2020-10-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Joshua Wiley

IPC: H01J49/00 ,  H01J49/42

Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

公开(公告)号：US20210358732A1

公开(公告)日：2021-11-18

申请号：US17179715

申请日：2021-02-19

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

IPC: H01J49/04 ,  C12N13/00 ,  C12Q1/04

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

公开(公告)号：US11127581B2

公开(公告)日：2021-09-21

申请号：US17040721

申请日：2019-03-18

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Lucas Szalwinski

IPC: H01J49/42

Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

公开(公告)号：US20210275986A1

公开(公告)日：2021-09-09

申请号：US17322339

申请日：2021-05-17

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  David Logsdon

IPC: B01J19/24 ,  B01J14/00 ,  B01J19/08 ,  B01J19/26 ,  B01D5/00 ,  B01D19/00 ,  B05B5/03 ,  B01J4/00

Abstract: The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.

公开(公告)号：US10937638B2

公开(公告)日：2021-03-02

申请号：US16047267

申请日：2018-07-27

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00

Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.

公开(公告)号：US10908165B2

公开(公告)日：2021-02-02

申请号：US16002749

申请日：2018-06-07

Applicant: Purdue Research Foundation ,  AMGEN INC.

Inventor： Stephen T. Ayrton ,  Robert Graham Cooks ,  Tawnya Flick ,  Da Ren

IPC: G01N33/68 ,  H01J49/10 ,  H01J49/00

Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.

公开(公告)号：US20210013023A1

公开(公告)日：2021-01-14

申请号：US17040721

申请日：2019-03-18

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder ,  Lucas Szalwinski

IPC: H01J49/42

Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

公开(公告)号：US20200340962A1

公开(公告)日：2020-10-29

申请号：US16905193

申请日：2020-06-18

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang

IPC: G01N30/95 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  G01N30/91 ,  G01N33/49

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.