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131.发明申请公开(公告)号：US20190185563A1
公开(公告)日：2019-06-20
申请号：US16284081
申请日：2019-02-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Michal Eisenbach-Schwartz , Kuti Baruch , Neta Rosenzweig
IPC: C07K16/28 , A61K38/02 , A61K38/00 , A61K31/4155 , A61K38/16 , A61K38/18 , A61K38/20 , A61K38/14 , A61K45/06 , A61K31/404 , A61K39/395 , A61K33/36 , A61K31/7068
CPC classification number: C07K16/2803 , A61K31/404 , A61K31/4155 , A61K31/7068 , A61K33/36 , A61K38/00 , A61K38/005 , A61K38/02 , A61K38/14 , A61K38/168 , A61K38/18 , A61K38/208 , A61K39/395 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2121/00 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , A61K2300/00
Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.
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公开(公告)号：US20190171673A1
公开(公告)日：2019-06-06
申请号：US16244139
申请日：2019-01-10
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Noam SOBEL , Lavi SECUNDO , Kobi SNITZ , Kineret WEISSLER , Liron PINCHOVER , Idan FRUMIN , Dana Shoshana BAR ZVI MILDWORF , Sagit SHUSHAN
IPC: G06F16/903 , G16H10/20 , A61B5/00
Abstract: A method of determining olfactory perception signature of a subject is disclosed. The method comprises: providing the subject with a plurality of physical odorant samples for sniffing; for each sniffed odorant sample, presenting to the subject, by a user interface, a set of odorant descriptors and a respective set of rating controls, and receiving ratings entered by the subject using the rating controls. Each rating is indicative of a descriptiveness of a respective odorant descriptor for the odorant sample, thereby obtaining a set of descriptiveness levels for the odorant sample. The method also comprises calculating, by a computer, relations between pairs of sets of descriptiveness levels corresponding to pairs of odorant samples, to provide a vector of relations, wherein the vector represents the olfactory perception signature of the subject.
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公开(公告)号：US20190153482A1
公开(公告)日：2019-05-23
申请号：US16217090
申请日：2018-12-12
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat , Yeda Research and Development Co. Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Itzhak MIZRAHI , Naama SHTERZER , Raphael LAMED , Inna ROZMAN GRINBERG , Edward A. BAYER , Sarah MORAIS , Etai LANDOU
Abstract: Lactic acid bacterial cultures, cell populations and articles of manufacture comprising same are disclosed for generating ethanol from lignocellulse.
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134.发明授权公开(公告)号：US10288622B2
公开(公告)日：2019-05-14
申请号：US14883685
申请日：2015-10-15
Inventor： Eran Ovadia , Irun R. Cohen , Johannes Herkel , Raanan Margalit , Meirav Pevsner-Fischer
IPC: G01N33/53 , C12Q1/64 , G01N33/68 , A61K38/08 , A61K38/18 , A61K38/30 , A61K45/06 , A61K31/343 , C07K7/06 , G01N33/543
Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
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公开(公告)号：US20190099466A1
公开(公告)日：2019-04-04
申请号：US15720767
申请日：2017-09-29
Inventor： Min-Chuan Huang , Syue-Ting Chen , Yu-Chun Liu
Abstract: Disclosed is a peptide consisting of an amino acid sequence of HisThrSerThrGluAlaLys (SEQ ID NO: 1). This peptide is effective in the enhancement of fibroblast cell migration, which promotes wound healing. Also provided are a pharmaceutical composition for promoting wound healing comprising the peptide, and a method for promoting wound healing using the peptide.
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Patent Agency Ranking
公开(公告)号：US10238113B2
公开(公告)日：2019-03-26
申请号：US14656693
申请日：2015-03-12
Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Robert Fluhr , Moshe Sagi
Abstract: The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides.
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公开(公告)号：US20190085350A1
公开(公告)日：2019-03-21
申请号：US16208640
申请日：2018-12-04
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Mark SAFRO , Liron KLIPCAN , Inbar MAYMON , Igal FINAROV
Abstract: Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.
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公开(公告)号：US10232009B1
公开(公告)日：2019-03-19
申请号：US15720767
申请日：2017-09-29
Inventor： Min-Chuan Huang , Syue-Ting Chen , Yu-Chun Liu
Abstract: Disclosed is a peptide consisting of an amino acid sequence of HisThrSerThrGluAlaLys (SEQ ID NO: 1). This peptide is effective in the enhancement of fibroblast cell migration, which promotes wound healing. Also provided are a pharmaceutical composition for promoting wound healing comprising the peptide, and a method for promoting wound healing using the peptide.
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公开(公告)号：US20190059314A1
公开(公告)日：2019-02-28
申请号：US16123248
申请日：2018-09-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph AHARONI , Prashant Sonawane , Maxim Itkin
CPC classification number: A01H6/82 , A01H5/10 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
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公开(公告)号：US20190055561A1
公开(公告)日：2019-02-21
申请号：US16180083
申请日：2018-11-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Alon CHEN , Orna ISSLER
IPC: C12N15/113 , C12Q1/6883 , C12N15/11
Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.
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