公开(公告)号：US12201688B2

公开(公告)日：2025-01-21

申请号：US18059726

申请日：2022-11-29

Applicant: Solventum Intellectual Properties Company

Inventor： Paul D. Wightman

IPC: A61K39/39 ,  A61K9/00 ,  A61K9/10 ,  A61K9/127 ,  A61K31/437 ,  A61K31/47 ,  A61K39/00 ,  A61K39/145 ,  A61K47/26 ,  C07D471/04 ,  C12N7/00

Abstract: The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a retrovirus vaccine adjuvant.

公开(公告)号：US12186144B2

公开(公告)日：2025-01-07

申请号：US17266431

申请日：2019-08-07

Applicant: Solventum Intellectual Properties Company

Inventor： Joseph C. Dingeldein ,  John M. Pilgrim ,  Christopher R. Kokaisel ,  Katelyn M. Languell ,  James D. Hansen

IPC: A61C13/107 ,  A61C5/20 ,  A61C13/00 ,  A61C13/20

Abstract: A custom tool for forming a dental restoration in a mouth of a patient. The custom tool includes a facial mold body for a patient-specific, customized fit with the facial side of at least one tooth of the patient, wherein the facial mold body includes a restorative portion, at least one aperture aligned with a portion of a surface of a tooth to be restored and at least one door having an inner surface forming a portion of the mold cavity encompassing missing tooth structure of the tooth to be restored, wherein the door mates with the aperture; a lingual mold body for a patient-specific, customized fit with the lingual side of the tooth of the patient, wherein the lingual mold body includes a restorative portion; wherein the facial mold body and lingual mold body are configured to interlock together; and wherein the facial mold body and lingual mold body are configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of at least one tooth to be restored.

公开(公告)号：US12178954B2

公开(公告)日：2024-12-31

申请号：US18389307

申请日：2023-11-14

Applicant: Solventum Intellectual Properties Company

Inventor： Timothy Mark Robinson ,  Tyler H. Simmons ,  Colin John Hall ,  Jeanette Losole

IPC: A61M1/00 ,  A61F13/00 ,  A61F13/0246 ,  A61F13/05

Abstract: A reduced-pressure system for treating a tissue site on a patient includes a distribution manifold that adheres to a tissue site to allow retention without external support. The distribution manifold includes a porous member and a tissue-fixation element. The tissue-fixation element maintains the porous member substantially adjacent to the tissue site while a sealing member is applied. In one instance, the tissue-fixation element is a soluble adhesive that partially covers either the tissue-facing side of the porous member or a tissue-facing side of a fluid-permeable substrate layer that is on the tissue-facing side of the porous member. Other systems, distributions manifolds, and methods are presented.

公开(公告)号：US12178687B2

公开(公告)日：2024-12-31

申请号：US17057543

申请日：2019-05-21

Applicant: Solventum Intellectual Properties Company

Inventor： Benjamin A. Pratt ,  Christopher B. Locke ,  James Seddon

IPC: A61F13/05 ,  A61B17/32 ,  A61M1/00 ,  A61B17/00 ,  A61M3/02

Abstract: A wound debridement system includes a wound dressing having an active layer (40) and a wound interface layer (10). The active layer is formed from one or more pneumatic members (45). The pneumatic members are arranged about a film layer (60), by which the pneumatic members are attached to the wound interface layer. A control unit (80) controls a drive unit (70) to intermittently apply pressure to the pneumatic members of the active layer. The pressure applied by the drive unit causes the pneumatic members to expand and contract. This movement of the pneumatic members is transferred to the wound interface layer, causing the wound interface layer to move relative to a tissue site to which the wound dressing is applied. The wound interface layer may be formed having an abrasive wound-facing surface, such that the movement of the wound interface layer causes a mechanical disruption and debridement of debris at the tissue site.

公开(公告)号：US12178598B2

公开(公告)日：2024-12-31

申请号：US17631923

申请日：2020-08-03

Applicant: Solventum Intellectual Properties Company

Inventor： Christopher Brian Locke ,  Richard Daniel John Coulthard ,  Timothy Mark Robinson

IPC: A61M1/00 ,  A61B5/00

Abstract: A therapy system for treating a tissue site with negative-pressure therapy and/or fluid instillation therapy in response to information received from a diagnostic module is described. The therapy system may include a dressing, a negative-pressure source, a container, and a diagnostic module. The dressing be placed on the tissue site, and the negative-pressure source may be fluidly coupled to the dressing. The container may be fluidly coupled to the dressing and to the negative-pressure source to receive fluid from the tissue site. The diagnostic module may be exposed to gas associated with the fluid from the tissue site. The diagnostic module may comprise a sensor configured to detect a condition of the tissue site and to generate an output based on the detected condition. The sensor may be configured to detect a volatile organic compound. The diagnostic module may be positioned on the container.

公开(公告)号：US12156787B2

公开(公告)日：2024-12-03

申请号：US16757642

申请日：2018-10-23

Applicant: Solventum Intellectual Properties Company

Inventor： Jonathan G. Rehbein ,  Luke Perkins ,  David Richard Mercer ,  Richard Marvin Kazala, Jr. ,  Larry Tab Randolph

IPC: A61F13/05 ,  A61B46/20 ,  A61F13/00 ,  A61F13/06 ,  A61L15/42 ,  A61M1/00

Abstract: A dressing for managing an incision and surrounding tissue where edema and swelling may be present post-operation. The dressing may maximize coverage of area in articulating joints, such as a knee or elbow, while allowing for substantial range of motion. In some embodiments, the dressing may comprise an adhesive border configured to be adhered to skin around an articulating joint, a skin-interfacing fabric for minimizing skin irritation, a foam body for manifolding negative pressure and absorbing exudate and other body fluids, and a thin polymer film cap for sealing the assembly so negative pressure can be maintained throughout the dressing.

公开(公告)号：US12156786B2

公开(公告)日：2024-12-03

申请号：US18241696

申请日：2023-09-01

Applicant: Solventum Intellectual Properties Company

Inventor： Timothy Mark Robinson ,  Christopher Brian Locke

IPC: A61F13/02 ,  A61B46/00 ,  A61F13/0246 ,  A61H9/00 ,  A61M1/00

Abstract: A medical drape for use with a reduced pressure system for providing reduced pressure to a tissue site is described. In some embodiments, the drape may include a flexible film, and an adhesive layer coupled to the flexible film. The adhesive layer may include a first adhesive disposed on a first portion of the flexible film in a first pattern. The first adhesive can be configured to secure the flexible film proximate to the tissue site. The adhesive layer generally includes a second adhesive disposed on a second portion of the flexible film in a second pattern. The second adhesive can be configured to seal the flexible film proximate to the tissue site. The first pattern and the second pattern are preferably registered so that the first portion and the second portion are offset to cover substantially different portions of the flexible film.

公开(公告)号：US12156775B2

公开(公告)日：2024-12-03

申请号：US18092562

申请日：2023-01-03

Applicant: Solventum Intellectual Properties Company

Inventor： Joseph C. Dingeldein ,  James D. Hansen ,  Katelyn M. Languell ,  Christopher M. Brown

IPC: A61C5/20 ,  A61C5/00 ,  A61C5/80 ,  A61C5/85 ,  A61C13/08 ,  A61C13/107 ,  A61C9/00

Abstract: A tool for forming a dental restoration includes a mold body configured to provide a customized fit with at least one tooth of a patient. In some examples, the mold body defines an aperture configured to align with a portion of a surface of a tooth. The aperture is sufficiently large to allow placement and flow of restorative material over the desired portion of the surface of the tooth to be restored. The mold body is configured to combine with the at least one tooth of the patient to define a mold cavity encompassing at least a portion of desired tooth structure of the tooth to be restored.

公开(公告)号：US12145082B2

公开(公告)日：2024-11-19

申请号：US17420338

申请日：2020-01-08

Applicant: Solventum Intellectual Properties Company

Inventor： Kannan Dasharathi ,  Jon P. Kragness

IPC: B01D15/22 ,  B01D15/36 ,  G01N30/06

Abstract: A chromatography device having a housing formed from an upper housing ultrasonically welded to a lower housing. A compression extension and a boss located inside of the housing with the media disposed between the compression extension and the boss such that a perimeter of the media is compressed between the compression extension and the boss forming a liquid impermeable seal along the perimeter after the upper housing is ultrasonically welded to the lower housing.

公开(公告)号：US12144922B2

公开(公告)日：2024-11-19

申请号：US17624958

申请日：2020-07-16

Applicant: Solventum Intellectual Properties Company

Inventor： Christopher A. Carroll ,  Christopher Brian Locke ,  Shannon C. Ingram ,  Justin Rice

IPC: A61M1/00 ,  A61F13/05

Abstract: A customizable wound treatment system for treating multiple zones of a wound includes a dressing configured for use with a first zone and a second zone of a wound that includes a first foam layer placed over the first zone, a second foam layer placed over the second zone, a first drape layer disposed over the first foam layer and beneath the second foam layer, and a second drape layer disposed over the second foam layer. The customizable wound treatment system includes a negative pressure source pneumatically coupled to the first foam layer and the second foam layer and operable to create a negative pressure at the first zone and the second zone and a fluid instillation pump fluidly coupled to the first foam layer and configured to instill a treatment fluid to the first zone.