公开(公告)号：US20190053898A1

公开(公告)日：2019-02-21

申请号：US16103973

申请日：2018-08-16

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Tamir S. Levi

IPC: A61F2/24

Abstract: An implantable prosthetic valve can include a radially expandable and collapsible annular frame comprising an inflow end and an outflow end. The frame can have a plurality of struts forming a plurality of cells, wherein each of the plurality of cells defines an opening in the frame. A leaflet structure can be positioned within the frame and secured thereto. A plurality of sealing members can be positioned within the openings of a plurality of the cells of the frame and secured thereto. Each of the plurality of sealing members can be positioned within a respective one of the openings.

公开(公告)号：US20180250127A1

公开(公告)日：2018-09-06

申请号：US15974099

申请日：2018-05-08

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Hernan Altman

IPC: A61F2/24

Abstract: A system is in various embodiments configured to treat a native heart valve, such as to secure a prosthetic heart valve within a native valve. Embodiments of the system include a docking device with different coil portions, such as an upper coil and a lower coil, where the device is configured to assume an axially expanded state and an axially compressed state. In the axially expanded state, the entire upper coil can be positioned on a first side of the lower coil relative to the central axis and/or the entire upper coil and the entire lower coil have a positive pitch relative to each other. In the axially compressed state, at least a portion of the upper coil can be positioned on a second side of at least a portion of the lower coil opposite to the first side relative to the central axis and/or at least a portion of the upper coil has a negative pitch relative to at least a portion of the lower coil.

公开(公告)号：US20170128199A1

公开(公告)日：2017-05-11

申请号：US15345857

申请日：2016-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Mohammad Jafari ,  Liron Tayeb ,  Ilan Tamir ,  Ziv Yohanan ,  Noam Nir ,  David Maimon ,  Boaz Manash

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2418

Abstract: Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A prosthetic valve may comprise a radially compressible main body and a one-way valve portion. The prosthetic valve may further comprise one or more ventricular anchors coupled to the main body and disposed outside of the main body. The ventricular anchors may be configured such that a reduced profile of the prosthetic valve is possible. A space may be provided between an outer surface of the main body and the ventricular anchors for receiving native mitral valve leaflets. The prosthetic valve may include an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for receiving the native mitral valve leaflets between the ventricular anchors and the main body are described.

公开(公告)号：US20160374802A1

公开(公告)日：2016-12-29

申请号：US15194375

申请日：2016-06-27

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

Abstract translation: 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。

公开(公告)号：US20160184096A1

公开(公告)日：2016-06-30

申请号：US15063319

申请日：2016-03-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung T. Le

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a coiled wire frame having a longitudinal opening extending from a proximal end to a distal end thereof. The opening has a first state and a second state, the opening in the first state having a first diameter dimensioned to receive the prosthetic valve in an expanded or partially crimped configuration therein, and the opening in the second state having a second diameter dimensioned to receive the prosthetic valve in a crimped configuration. The coiled wire frame has a first end coupled to a first member and a second end coupled to a second member. The first member is movable relative to the second member to convert the coiled wire frame from the first state to the second state.

Abstract translation: 用于压缩可径向膨胀和可折叠的人工瓣膜的装置包括具有从近端延伸到其远端的纵向开口的螺旋线框架。 所述开口具有第一状态和第二状态，所述第一状态下的开口具有第一直径，所述第一直径的尺寸被设计成接收处于其中的膨胀或部分卷曲构造的所述人造瓣膜，并且所述第二状态中的所述开口的尺寸设计成接收 人造瓣膜处于卷曲结构。 盘绕的线框架具有联接到第一构件的第一端和联接到第二构件的第二端。 第一构件可相对于第二构件移动，以将盘绕的线框架从第一状态转换到第二状态。

公开(公告)号：US08652145B2

公开(公告)日：2014-02-18

申请号：US13715605

申请日：2012-12-14

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung Le

IPC: B21D41/00 ,  A61B17/06 ,  B23P11/00

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  A61F2002/9522 ,  B21D41/04 ,  B23P19/04 ,  B25B27/10 ,  Y10T29/53552 ,  Y10T29/53578 ,  Y10T29/5367

Abstract: An exemplary system for crimping a prosthetic valve comprises a radially expandable and compressible prosthetic valve, a crimping device positioned around the valve and configured to reduce the diameter of the valve to a delivery configuration, and a sterile package enclosing the valve and the crimping device. The valve can be pre-assembled in a partially crimped configuration within the crimping device. After removing the sterile packaging, the crimping device can be used to crimp the valve from the partially crimped configuration to the delivery configuration, such as by twisting a knob on the crimping device. The system can further comprise at least a portion of a delivery catheter within the sterile package, wherein the valve is pre-mounted on or adjacent to an inflatable balloon of the delivery catheter, such that the valve can be crimped onto the delivery catheter using the crimping device.

Abstract translation: 用于卷曲假体瓣膜的示例性系统包括径向可膨胀和可压缩的人造瓣膜，围绕阀门定位并构造成将阀的直径减小到输送构造的压接装置，以及封闭阀和压接装置的无菌包装。 阀可以在压接装置内以部分压接构造预先组装。 在去除无菌包装之后，卷曲装置可以用于将阀从部分压接构型压接到输送构型，例如通过扭曲压接装置上的旋钮。 所述系统还可以包括在无菌包装内的输送导管的至少一部分，其中所述瓣膜被预先安装在所述输送导管的可充气球囊上或邻近所述输送导管的可充气气囊，使得所述阀可以使用 压接装置。