公开(公告)号：US11027135B2

公开(公告)日：2021-06-08

申请号：US15966523

申请日：2018-04-30

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Jeffrey M. Gillberg ,  Robert W. Stadler

IPC: A61B5/05 ,  A61N1/368 ,  A61B5/02 ,  A61N1/04 ,  A61N1/362 ,  A61B5/282 ,  A61B5/316 ,  A61B5/318 ,  A61B5/339 ,  A61B5/349 ,  A61B5/00

Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

公开(公告)号：US20210106832A1

公开(公告)日：2021-04-15

申请号：US17031201

申请日：2020-09-24

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Jeffrey M. Gillberg ,  Trent M. Fischer

IPC: A61N1/365 ,  A61B5/0408 ,  A61B5/021 ,  A61B5/026 ,  A61B5/044 ,  A61B5/00 ,  A61N1/37 ,  A61N1/39

Abstract: Systems and methods are described herein for use in synchronizing electrical activity monitored by a plurality of external electrodes with supplemental cardiac data for use in evaluating a patient's cardiac condition and configuring cardiac therapy. The supplemental cardiac data may include one or more markers indicative of the occurrence of cardiac events and/or data representative of representative of at least one of cardiac electrical signals, cardiac sounds, cardiac pressures, blood flow, and an estimated instantaneous flow waveform provided by a left ventricular assist device.

公开(公告)号：US20210106245A1

公开(公告)日：2021-04-15

申请号：US17031189

申请日：2020-09-24

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61B5/04 ,  A61B5/042 ,  A61B5/0472 ,  A61B5/0456 ,  A61N1/37

Abstract: Systems and methods are described herein for evaluation and configuration cardiac therapy. The systems and methods may monitor electrical activity using a plurality of external electrodes and may utilize multiple-electrode cardiac metrics such as electrical heterogeneity information, single-electrode cardiac metrics, and vectorcardiographic metrics to determine and select one or more paced settings from a plurality of different paced settings.

公开(公告)号：US10780279B2

公开(公告)日：2020-09-22

申请号：US15142118

申请日：2016-04-29

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/372 ,  A61N1/365 ,  A61B5/00 ,  A61N1/368 ,  A61B5/0408 ,  A61B5/0452 ,  A61N1/362 ,  A61B5/0428 ,  A61B5/04 ,  A61B5/044 ,  A61B5/0245 ,  A61N1/37

Abstract: Methods and systems of evaluating cardiac pacing in candidate patients for cardiac resynchronization therapy and cardiac resynchronization therapy patients are disclosed. The methods and systems disclosed allow treatments to be personalized to patients by measuring the extent of tissue capture from cardiac pacing under various therapy parameter conditions. Systems and methods of optimizing right ventricle only cardiac pacing are also disclosed.

公开(公告)号：US10773085B2

公开(公告)日：2020-09-15

申请号：US15915995

申请日：2018-03-08

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  D'Anne Kudlik ,  Ya-Jian Cheng

IPC: A61B5/04 ,  A61N1/365 ,  A61N1/37 ,  A61B5/0452 ,  A61N1/362 ,  A61B5/00 ,  A61B5/042 ,  A61B5/0408 ,  A61B5/0456 ,  A61B5/0472 ,  A61B5/0428

Abstract: The exemplary systems and methods may be configured to generate a dispersion signal from a plurality of cardiac signals and determine a QRS onset time value and a QRS offset time value from the plurality of cardiac signals. The QRS onset and offset time values may be used to measure, or capture, activation times.

公开(公告)号：US10449365B2

公开(公告)日：2019-10-22

申请号：US15368199

申请日：2016-12-02

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61B5/00 ,  A61B5/04 ,  A61N1/365 ,  A61B5/0402 ,  A61B5/0452 ,  A61N1/362 ,  A61N1/368 ,  A61B5/0408 ,  A61B5/11

Abstract: An exemplary computer-implemented method is disclosed for detection of onset of depolarization on far-field electrograms (EGMs) or electrocardiogram (ECG)-or ECG-like signals. The method includes determining a baseline rhythm using a plurality of body-surface electrodes. The baseline rhythm includes an atrial marker and a ventricular marker. A pre-specified window is defined as being between the atrial marker and the ventricular marker. A low pass filter is applied to a signal within the window. A rectified slope of the signal within the window is determined. A determination is made as to whether a time point (t1) is present such that the rectified slope exceeds 10% of a maximum value of the rectified slope. A point of onset of a depolarization complex in the signal is determined. The point of onset occurs at a largest curvature in the signal within the window.

公开(公告)号：US20190299012A1

公开(公告)日：2019-10-03

申请号：US15944050

申请日：2018-04-03

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/375 ,  A61N1/37

Abstract: A method and system that includes an implantable cardioverter defibrillator (ICD) determining signal characteristics of a cardiac signal within a signal evaluation window positioned along a first portion of a cardiac cycle and determining whether a P-wave occurs within the signal evaluation window associated with the first portion of the cardiac cycle. The signal evaluation window is adjusted to be positioned along a second portion of the cardiac cycle in response to the P-wave not occurring within the signal evaluation window and signal characteristics of the cardiac signal are determined within the adjusted signal evaluation window. A determination is made as to whether a P-wave occurs in response to the signal characteristics determined within the adjusted signal evaluation window, and the ICD delivers a trigger signal to a leadless pacing device instructing delivery of ventricular pacing therapy by the leadless pacing device whenever a P-wave is determined to occur.

公开(公告)号：US20190298903A1

公开(公告)日：2019-10-03

申请号：US16369913

申请日：2019-03-29

Applicant: Medtronic, Inc.

Inventor： Jeffrey M. Gillberg ,  Subham Ghosh ,  Michael F. Hess ,  Troy E. Jackson

IPC: A61M1/10 ,  A61M1/12 ,  A61B5/0408 ,  A61B5/00

Abstract: Systems and methods are described herein for evaluation and adjustment of a left ventricular assist device (LVAD). The systems and methods may utilize at least a plurality of external electrodes to monitor cardiac electrical activity before and during LVAD therapy. The cardiac electrical activity as well as other information such cardiac sound information may be used to determine and adjust one or more LVAD output parameters such as pump speed.

公开(公告)号：US20190290915A1

公开(公告)日：2019-09-26

申请号：US16361996

申请日：2019-03-22

Applicant: Medtronic, Inc.

Inventor： Zhongping Yang ,  Thomas A. Anderson ,  Brian P. Colin ,  William J. Clemens ,  Subham Ghosh ,  Jeffrey M. Gillberg ,  Maurice T. I. Verbeek ,  Toine Camps ,  Lilian Kornet ,  Berthold Stegemann ,  Jean Rutten

IPC: A61N1/368 ,  A61N1/05 ,  A61N1/365 ,  A61N1/375 ,  A61B5/042

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

公开(公告)号：US20190275339A1

公开(公告)日：2019-09-12

申请号：US15914396

申请日：2018-03-07

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Zhongping Yang

IPC: A61N1/37 ,  A61N1/39 ,  A61N1/05 ,  A61N1/372

Abstract: A system and method of positioning an atrial pacing lead for delivery of a cardiac pacing therapy that includes sensing electrical activity of tissue of a patient from a plurality of external electrodes and determining a distribution of bi-atrial activation in response to the sensed electrical activity. A target site for delivering the atrial pacing therapy is adjusted based on a change in bi-atrial dyssynchrony that is determined in response to the determined distribution of bi-atrial activation, and placement of the atrial pacing lead for delivery of the atrial pacing therapy is determined in response to the adjusting.