公开(公告)号：US20210047379A1

公开(公告)日：2021-02-18

申请号：US16991517

申请日：2020-08-12

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Luigi MANNI ,  Marzia SOLIGO

IPC: C07K14/475 ,  C07K16/22 ,  A61P25/28

Abstract: A protease-resistant neurotrophic peptide for use as a medicament in the therapeutic treatment of neurodegenerative and/or epithelial/cutaneous diseases is described. A pharmaceutical composition comprising the neurotrophic peptide in a pharmaceutically acceptable carrier, as well as in combination with optional adjuvants, stabilizers and/or preservatives, is also described.

公开(公告)号：US20200337824A1

公开(公告)日：2020-10-29

申请号：US16955851

申请日：2018-12-18

Applicant: POLITECNICO DI MILANO ,  UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Manuela Teresa Raimondi ,  Giulio Cerullo ,  Claudio Conci ,  Tommaso Zandrini ,  Roberto Osellame ,  Giuseppe Chirico

IPC: A61F2/00

Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.

公开(公告)号：US10780149B2

公开(公告)日：2020-09-22

申请号：US16252972

申请日：2019-01-21

Applicant: Consiglio Nazionale Delle Ricerche

Inventor： Sara Marinelli ,  Flaminia Pavone ,  Siro Luvisetto ,  Valentina Vacca

IPC: A61K38/48 ,  A61K9/00 ,  A61P25/00

Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, in the therapeutic treatment of paralysis caused by spinal cord injury.

公开(公告)号：US10722574B2

公开(公告)日：2020-07-28

申请号：US16007685

申请日：2018-06-13

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Angelo Fontana ,  Emiliano Manzo ,  Adele Cutignano ,  Raffaele De Palma

IPC: A61K39/39 ,  C07H13/06

Abstract: The present invention relates to beta-glycolipid derivatives, their preparation and use as adjuvants in vaccines, as being suitable for being co-administered with antigens for vaccine prophylaxis and therapy. In certain embodiments, the beta-glycolipid derivatives of the invention also in their salified or complex form, are suitable for being co-administered with antigens for both therapeutic and prophylactic purposes or for vaccine prophylaxis and therapy.

公开(公告)号：US20200206138A1

公开(公告)日：2020-07-02

申请号：US16622402

申请日：2018-06-13

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Annalisa ALUIGI ,  Greta VARCHI ,  Giovanna SOTGIU ,  Andrea GUERRINI ,  Marco BALLESTRI

IPC: A61K9/16 ,  A61K8/65 ,  A61K9/00 ,  A61K31/704 ,  A61K31/337 ,  A61P35/00 ,  A61K31/20

Abstract: A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.

公开(公告)号：US10682633B2

公开(公告)日：2020-06-16

申请号：US15545536

申请日：2016-01-21

Applicant: UNIVERSITÉ DE STRASBOURG ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Cuong Pham-Huu ,  Giuliano Giambastiani ,  Yuefeng Liu ,  Housseinou Ba ,  Lam Nguyen-Dinh ,  Jean-Mario Nhut ,  Cuong Duong-Viet

IPC: B01J20/20 ,  B01J27/24 ,  B01J21/04 ,  B01J27/224 ,  H01M4/96 ,  B01J27/20 ,  B01J37/02 ,  B01J21/18 ,  B01J35/00 ,  B01J35/02 ,  B01J35/10 ,  B01J37/04 ,  C01B17/04 ,  C07C5/333

Abstract: Some embodiments are directed to a new methodology aimed at preparing highly N-doped mesoporous carbon macroscopic composites, and their use as highly efficient heterogeneous metal-free catalysts in a number of industrially relevant catalytic transformations.

公开(公告)号：US20200058814A1

公开(公告)日：2020-02-20

申请号：US16487407

申请日：2018-02-20

Applicant: ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： PAOLA CERONI ,  RAFFAELLO MAZZARO ,  GIACOMO BERGAMINI ,  ANTONINO ARRIGO ,  FRANCESCO ROMANO ,  VITTORIO MORANDI ,  MARIACONCETTA CANINO

IPC: H01L31/055 ,  H01L31/054 ,  C09K11/02 ,  C09K11/59

Abstract: An energy conversion device, particularly electromagnetic energy, such as sunlight and the like, comprising a transparent polymer sheet having an edge and a surface, on which said electromagnetic radiation can impact, and a photovoltaic cell mechanically coupled with said edge of said polymer sheet, capable of transforming in an electrical current the radiation incident on it, characterized in that said polymer sheet comprises a polymeric matrix having silicon nanostructures, functionalized with organic binders, said polymeric sheet being then luminescent with respect to a portion of said electromagnetic radiation, so as to convey the same, through a wave-guide, towards said photovoltaic cell. Also disclosed is a method for realizing a polymeric matrix, for the manufacture of a transparent polymer sheet.

公开(公告)号：US20200030566A1

公开(公告)日：2020-01-30

申请号：US16489504

申请日：2018-02-27

Applicant: Consiglio Nazionale Delle Ricerche

Inventor： Monica SANDRI ,  Anna TAMPIERI ,  Simone SPRIO

IPC: A61M16/10 ,  C08J3/075

Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.

公开(公告)号：US10301367B2

公开(公告)日：2019-05-28

申请号：US15328833

申请日：2015-07-24

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Claudio Passananti ,  Nicoletta Corbi ,  Maria Grazia Di Certo ,  Elisabetta Mattei ,  Cinzia Pisani ,  Georgios Strimpakos ,  Siro Luvisetto

IPC: C07K14/47 ,  A61K38/17 ,  A61K48/00 ,  C12N15/62

Abstract: The present invention features modified human transcription factors capable of increasing utrophin expression, recombinant adeno-associated vectors for delivery of the modified human transcription factors, and methods of treating muscle diseases, including Duchenne's muscular dystrophy.

公开(公告)号：US20190127633A1

公开(公告)日：2019-05-02

申请号：US16077593

申请日：2017-02-10

Applicant: UNIVERSITÉ D'ANGERS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  CONSIGLIO NAZIONALE DELLE RICERCHE (CNR)

Inventor： Oksana TOMA ,  Nicolas MERCIER ,  Chiara BOTTA

IPC: C09K11/06

Abstract: Some embodiments are directed to a mechanoluminescence material including a first compound and a second compound, each of which contains a bi-pyridine or pyridine that includes an N-oxide group bound to an ns2 metal cation from the p block. The second compound of the material is obtained by grinding a compound that is identical to the first one.