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    Microfluidic network
    172.
    发明授权
    Microfluidic network 有权

    公开(公告)号：US11331669B2

    公开(公告)日：2022-05-17

    申请号：US16477772

    申请日：2017-02-15

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Pavel Kornilovich ,  Alexander Govyadinov ,  Nick McGuinness

    IPC: B01L3/00

    Abstract: An apparatus may include a first microfluidic valve coupled between a first reservoir and a fluid channel. The first microfluidic valve may include a fluid agitator to break a meniscus formed at an air-fluid interface and release fluid from the first reservoir into the fluid channel in response to an electrical signal. The apparatus may also include a second microfluidic valve coupled between a second reservoir and the fluid channel. Fluid from the first reservoir and fluid from the second reservoir mix in the fluid channel.

    SINGLE CELL TRANSFECTION WITH INTERCHANGEABLE REAGENT
    173.
    发明申请
    SINGLE CELL TRANSFECTION WITH INTERCHANGEABLE REAGENT 有权

    公开(公告)号：US20220145331A1

    公开(公告)日：2022-05-12

    申请号：US17429962

    申请日：2019-06-24

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

    IPC: C12N15/87 ,  C12M1/42 ,  B01L3/00

    Abstract: Examples disclosed herein relate to single cell transfection with interchangeable reagent. The present disclosure relates generally to a device, method, and system for single cell transfection including a transfection chamber on a transfection chip. The example system may include a fluidic channel located on the transfection chip for guiding a cell towards the transfection chamber, the fluidic channel sized to allow no more than a single cell to arrive at the transfection chamber at a time. The example system may also include a reagent receiver located on the transfection chip guiding received reagent towards the transfection chamber and intersecting with the path of the fluidic channel.

    Microfluidic fluid flow in a target fluid
    175.
    发明授权
    Microfluidic fluid flow in a target fluid 有权

    公开(公告)号：US11318466B2

    公开(公告)日：2022-05-03

    申请号：US16618200

    申请日：2017-07-19

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： David P. Markel ,  Erik D Torniainen ,  Alexander Govyadinov ,  Pavel Kornilovich

    IPC: B01L3/00

    Abstract: One example includes a device that may include a heating element and a molecular binding site. The heating element may heat a fluid volume, interfaced with the heating element, in response to a voltage being applied to the heating element, the heat transforming the fluid volume from a liquid state into a vaporized state to generate fluid motion within the fluid volume. The molecular binding site may be disposed proximate to the heating element, in which a portion of the fluid volume expands when the fluid volume transforms from the liquid state into the vaporized state, the vaporized state of the fluid volume generating the fluid motion within a target fluid that is disposed within the molecular binding site.

    MODULAR AND TILED OPTICAL SENSORS
    176.
    发明申请
    MODULAR AND TILED OPTICAL SENSORS 有权

    公开(公告)号：US20220113255A1

    公开(公告)日：2022-04-14

    申请号：US17417533

    申请日：2019-04-30

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Brett E. Dahlgren ,  Brian John Keefe

    IPC: G01N21/64

    Abstract: An example device includes an array of sensor modules. A sensor module includes a body to be positioned in alignment with a planar target, a light source coupled to the body to emit light to the planar target along a source optical path, and a plurality of light sensors coupled to the body. Each light sensor is to sense a different wavelength of light received from the planar target along a sensor optical path. The sensor optical path is different from the source optical path. The bodies of the array of sensor modules are arranged in a planar tiling pattern with respect to a longitudinal axis of the planar target.

    CELL LYSIS WITH A MICROBEAD AND THERMAL RESISTOR
    177.
    发明申请
    CELL LYSIS WITH A MICROBEAD AND THERMAL RESISTOR 有权

    公开(公告)号：US20220112453A1

    公开(公告)日：2022-04-14

    申请号：US17417538

    申请日：2019-04-30

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Pavel Kornilovich ,  Alexander Govyadinov ,  Jared Johnson

    IPC: C12N1/06 ,  C12N15/10 ,  B01L3/00

    Abstract: Examples herein involve cell lysis with a microbead and thermal resistor. An example apparatus includes a microfluidic channel to pass a volume including a microbead and a biologic sample having nucleic acids enclosed within a cellular membrane. A first thermal resistor may be disposed within the microfluidic channel to move the biologic sample through the microfluidic channel and lyse the cellular membranes in the biologic sample to release the nucleic acids. A microfilter disposed within the microfluidic channel may filter the microbead from the biologic sample and permit the nucleic acids to pass through the filter.

    Temperature-controlling microfluidic devices
    178.
    发明授权
    Temperature-controlling microfluidic devices 有权

    公开(公告)号：US11278894B2

    公开(公告)日：2022-03-22

    申请号：US16643693

    申请日：2017-11-22

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Adam Higgins ,  Alexander Govyadinov

    IPC: B01L7/00 ,  B01L3/00

    Abstract: The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a driver chip and a fluid chamber located over the driver chip. First and second microfluidic loops can have fluid driving ends and fluid outlet ends connected to the fluid chamber. The first and second microfluidic loops can include a portion thereof located outside a boundary of the driver chip. A first fluid actuator can be on the driver chip associated with the fluid driving end of the first microfluidic loop to circulate fluid through the first microfluidic loop. A second fluid actuator can be on the driver chip associated with the fluid driving end of the second microfluidic loop to circulate fluid through the second microfluidic loop.

    MICROFLUIDIC CONCENTRATING PARTICLIZERS
    179.
    发明申请
    MICROFLUIDIC CONCENTRATING PARTICLIZERS 有权

    公开(公告)号：US20220072549A1

    公开(公告)日：2022-03-10

    申请号：US17417280

    申请日：2019-04-30

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

    IPC: B01L3/00 ,  G01N1/40 ,  B01F13/00

    Abstract: The present disclosure relates to a microfluidic concentrating particlizers including a particle generator, a particle concentrator, and a fluid movement network. The particle generator includes a sample inlet microchannel and a reagent inlet microchannel. The sample inlet microchannel is operable to direct a source sample. The reagent inlet microchannel is operable to direct reagent. The source sample and reagent come in contact to form a sample fluid dispersion including sample-modified particulates and fluid. The particle concentrator includes a filtering chamber fluidly coupled to the particle generator to concentrate sample-modified particulates relative to the fluid. The fluid movement network includes multiple pumps to generate fluidic flow through both the particle generator and the particle concentrator.

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