公开(公告)号：US20120202835A1

公开(公告)日：2012-08-09

申请号：US13500698

申请日：2010-10-08

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/506 ,  A61P35/00

CPC classification number: A61K31/4155 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基） 吡啶-2-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐和N - {（1S）-2-氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4 - （4-氯-1-甲基-1H-吡唑-5-基）-2-噻吩甲酰胺或其药学上可接受的盐。

公开(公告)号：US20120184164A1

公开(公告)日：2012-07-19

申请号：US13273749

申请日：2011-10-14

Applicant: Rakesh Kumar Gupta ,  Melvin Glenn Mitchell ,  Daniel William Klosiewicz ,  Mark Dwight Clark ,  Chris Delbert Anderson ,  Marvin Lynn Mitchell ,  Paula Hines Mitchell ,  Amber Layne Wolfe

Inventor： Rakesh Kumar Gupta ,  Melvin Glenn Mitchell ,  Daniel William Klosiewicz ,  Mark Dwight Clark ,  Chris Delbert Anderson ,  Marvin Lynn Mitchell ,  Paula Hines Mitchell ,  Amber Layne Wolfe

IPC: D04H5/00

CPC classification number: D21H13/02 ,  D21H13/12 ,  D21H13/20 ,  Y10T442/2008 ,  Y10T442/608

Abstract: A paperboard and a cardboard comprising at least one nonwoven web layer are provided. The nonwoven web layer comprises a plurality of first fibers, a plurality of second fibers, and a binder. The first fibers comprise a water non-dispersible synthetic polymer and have a different configuration and/or composition than the second fibers. The first fibers have a length of less than 25 millimeters and a minimum transverse dimension of less than 5 microns. The nonwoven web layer comprises at least 1 weight percent of the first fibers, at least 10 weight percent of the second fibers, and at least 1 weight percent of the binder. The paperboard and cardboard can incorporate a large amount of post consumer recycled fibers and still exhibit high strength and durability. Also disclosed is a process for producing the first fibers and the multicomponent fibers from which they are derived.

Abstract translation: 提供包含至少一个非织造纤维网层的纸板和纸板。 非织造纤维网层包括多个第一纤维，多个第二纤维和粘合剂。 第一纤维包含水不分散的合成聚合物并且具有与第二纤维不同的构型和/或组成。 第一纤维的长度小于25毫米，最小横向尺寸小于5微米。 非织造纤维网层包含至少1重量％的第一纤维，至少10重量％的第二纤维和至少1重量％的粘合剂。 纸板和纸板可以并入大量的消费后再生纤维，并且仍然表现出高强度和耐久性。 还公开了用于生产它们所衍生的第一纤维和多组分纤维的方法。

公开(公告)号：US20120175298A1

公开(公告)日：2012-07-12

申请号：US13273737

申请日：2011-10-14

Applicant: Rakesh Kumar Gupta ,  Melvin Glenn Mitchell ,  Daniel William Klosiewicz ,  Mark Dwight Clark ,  Chris Delbert Anderson ,  Marvin Lynn Mitchell ,  Paula Hines Mitchell ,  Amber Layne Wolfe

Inventor： Rakesh Kumar Gupta ,  Melvin Glenn Mitchell ,  Daniel William Klosiewicz ,  Mark Dwight Clark ,  Chris Delbert Anderson ,  Marvin Lynn Mitchell ,  Paula Hines Mitchell ,  Amber Layne Wolfe

IPC: B01D39/16 ,  B01D39/20 ,  B01D39/14 ,  B01D39/18

CPC classification number: B01D39/163 ,  B01D39/18 ,  B01D39/2024 ,  B01D39/2065 ,  B01D39/2089 ,  B01D2239/064 ,  B01D2239/1225 ,  B01D2239/1233

Abstract: A high efficiency filter comprising at least one nonwoven web layer is provided. The nonwoven web layer comprises a plurality of first fibers, a plurality of second fibers, and a binder. The first fibers comprise a water non-dispersible synthetic polymer and have a different configuration and/or composition than the second fibers. The first fibers have a length of less than 25 millimeters and a minimum transverse dimension of less than 5 microns. The nonwoven web layer comprises at least 15 weight percent of the first fibers, at least 10 weight percent of the second fibers, and at least 1 weight percent of the binder. The high efficiency filter has a filtration efficiency of 85% (DIN EN 1822) or higher. Also disclosed is a process for producing the first fibers and the multicomponent fibers from which they are derived.

Abstract translation: 提供了包括至少一个非织造纤维网层的高效过滤器。 非织造纤维网层包括多个第一纤维，多个第二纤维和粘合剂。 第一纤维包含水不分散的合成聚合物并且具有与第二纤维不同的构型和/或组成。 第一纤维的长度小于25毫米，最小横向尺寸小于5微米。 非织造纤维网层包含至少15重量％的第一纤维，至少10重量％的第二纤维和至少1重量％的粘合剂。 高效过滤器的过滤效率为85％（DIN EN 1822）或更高。 还公开了用于生产它们所衍生的第一纤维和多组分纤维的方法。

公开(公告)号：US08193180B2

公开(公告)日：2012-06-05

申请号：US12524435

申请日：2008-01-23

Applicant: Laurent Brard ,  Rakesh Kumar Singh ,  Kyu Kwang Kim ,  Giselle Saulnier-Sholler

Inventor： Laurent Brard ,  Rakesh Kumar Singh ,  Kyu Kwang Kim ,  Giselle Saulnier-Sholler

IPC: C07D417/12 ,  A61K31/541

CPC classification number: A61K31/54 ,  C07D279/12 ,  C07D417/12

Abstract: This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

Abstract translation: 本发明包括N-氨基四氢噻嗪游离碱及其盐的创新合成。 本发明还包括使用衍生物及其治疗应用作为抗癌剂。 此外，本发明包括其制造和使用。

公开(公告)号：US08173754B2

公开(公告)日：2012-05-08

申请号：US12304601

申请日：2007-03-09

Applicant: Rakesh Kumar Khandal ,  Amita Malik ,  Geetha Seshadri ,  Gouri Shankar Jha ,  Mukti Tyagi

Inventor： Rakesh Kumar Khandal ,  Amita Malik ,  Geetha Seshadri ,  Gouri Shankar Jha ,  Mukti Tyagi

IPC: C08F2/00 ,  C08F30/04 ,  C08F20/06 ,  C23C16/06 ,  B05D3/10

CPC classification number: C08F230/04 ,  C08F220/06 ,  G02B1/041 ,  C08L33/02

Abstract: This invention relates to a process for the preparation of plastic material for use in optical lenses comprising the steps of: a) synthesizing lead acrylate by adding lead monoxide to NaoH, which is stirred to obtain a homogenous mixture, b) adding an inhibitor to such a monomer mixture; c) adding acrylic acid drop wise to such a monomer mixture so as to avoid the formation of by products, d) heating the mixture of step (c) to a temperature of 35 to 45° C. till a white precipitate of lead acrylate is obtained, e) filtering, washing and drying the precipitate, f) subjecting lead acrylate to the step of polymerization by stepwise heating.

Abstract translation: 本发明涉及一种用于制备用于光学透镜的塑料材料的方法，包括以下步骤：a）通过向NaoH中加入一氧化铅合成丙烯酸铅，将其搅拌得到均匀的混合物，b）向其中加入抑制剂 单体混合物; c）将丙烯酸滴加到这种单体混合物上以避免产物形成，d）将步骤（c）的混合物加热至35-45℃，直至丙烯酸铅的白色沉淀物为 e）过滤，洗涤和干燥沉淀物，f）使丙烯酸铅经过逐步加热进行聚合步骤。

公开(公告)号：US08107386B2

公开(公告)日：2012-01-31

申请号：US12027725

申请日：2008-02-07

Applicant: Rakesh Kumar ,  Jay Shah ,  Jason Xiaoguang Chen

Inventor： Rakesh Kumar ,  Jay Shah ,  Jason Xiaoguang Chen

IPC: H04J1/16

CPC classification number: H04L45/22 ,  H04L43/0811 ,  H04L45/04 ,  H04L45/28 ,  H04L45/68

Abstract: In one example embodiment, a system and method is provided that includes establishing a plurality of Pseudo Wire (PW) connections between a first network appliance region and a second network appliance region to transmit data from the first network appliance region to the second network appliance region along an active PW. Further, the method includes disabling the active PW when a failure of the active PW is detected. Additionally, the method may include selecting an inactive PW to become a new active PW such that the data may be transmitted from the first network appliance region to the second network appliance region. Moreover, the method includes switching from the active PW to the new active PW.

Abstract translation: 在一个示例实施例中，提供了一种系统和方法，其包括在第一网络设备区域和第二网络设备区域之间建立多条伪线（PW）连接，以将数据从第一网络设备区域传输到第二网络设备区域 沿着主动PW。 此外，该方法包括当检测到活动PW的故障时禁用活动PW。 此外，该方法可以包括选择不活动的PW以成为新的活动PW，使得数据可以从第一网络设备区域发送到第二网络设备区域。 此外，该方法包括从主动PW切换到新的主动PW。

公开(公告)号：US20120019324A1

公开(公告)日：2012-01-26

申请号：US13247137

申请日：2011-09-28

Applicant: Rakesh KUMAR ,  Gireesh RAJENDRAN ,  Rittu Sachdev SINGH

Inventor： Rakesh KUMAR ,  Gireesh RAJENDRAN ,  Rittu Sachdev SINGH

IPC: H03F3/45

CPC classification number: H03F3/45179 ,  H03F3/45475 ,  H03F3/45632 ,  H03F3/45928 ,  H03F2200/168 ,  H03F2200/411 ,  H03F2203/45512

Abstract: An amplifier includes a first pair of transistors (the first pair) that defines a first output, each transistor of the first pair having a gate coupled to a first input terminal; a second pair of transistors (the second pair) that defines a second output, each transistor of the second pair having a gate coupled to a second input terminal; a first capacitor coupled to the second output terminal and to the gate of a first transistor of the first pair; a second capacitor coupled to the second output terminal and to the gate of a second transistor of the first pair; a third capacitor coupled to the first output terminal and to the gate of a third transistor of the second pair; and a fourth capacitor coupled to the first output terminal and to the gate of a fourth transistor of the second pair.

Abstract translation: 放大器包括限定第一输出的第一对晶体管（第一对），第一对的每个晶体管具有耦合到第一输入端的栅极; 限定第二输出的第二对晶体管（第二对），第二对的每个晶体管具有耦合到第二输入端的栅极; 第一电容器，耦合到所述第二输出端子和所述第一对的第一晶体管的栅极; 耦合到所述第二输出端子和所述第一对的第二晶体管的栅极的第二电容器; 耦合到所述第一输出端子和所述第二对的第三晶体管的栅极的第三电容器; 以及耦合到所述第一输出端子和所述第二对的第四晶体管的栅极的第四电容器。

公开(公告)号：US20120002869A1

公开(公告)日：2012-01-05

申请号：US13134885

申请日：2011-06-20

Applicant: Feng Han ,  Ying Shan ,  Harpreet Singh Sawhney ,  Rakesh Kumar

Inventor： Feng Han ,  Ying Shan ,  Harpreet Singh Sawhney ,  Rakesh Kumar

IPC: G06K9/62

CPC classification number: G06K9/6256

Abstract: The present invention provides a computer implemented process for detecting multi-view multi-pose objects. The process comprises training of a classifier for each intra-class exemplar, training of a strong classifier and combining the individual exemplar-based classifiers with a single objective function. This function is optimized using the two nested AdaBoost loops. The first loop is the outer loop that selects discriminative candidate exemplars. The second loop, the inner loop selects the discriminative candidate features on the selected exemplars to compute all weak classifiers for a specific position such as a view/pose. Then all the computed weak classifiers are automatically combined into a final classifier (strong classifier) which is the object to be detected.

Abstract translation: 本发明提供了一种用于检测多视点多姿态对象的计算机实现过程。 该过程包括针对每个类内样本的分类器的训练，强分类器的训练和将单个基于样本的分类器与单个目标函数组合。 使用两个嵌套的AdaBoost循环来优化此功能。 第一个循环是选择区分候选样本的外循环。 第二个循环，内循环选择所选样本上的鉴别候选特征，以计算特定位置（例如视图/姿态）的所有弱分类器。 然后将所有计算的弱分类器自动组合成最终分类器（强分类器），该分类器是要检测的对象。

公开(公告)号：US08088804B2

公开(公告)日：2012-01-03

申请号：US12097307

申请日：2006-12-04

Applicant: Rakesh Kumar Jain ,  Mikhail Fedorovich Gordeev ,  Jason Gustaf Lewis ,  Charles Francavilla

Inventor： Rakesh Kumar Jain ,  Mikhail Fedorovich Gordeev ,  Jason Gustaf Lewis ,  Charles Francavilla

IPC: A61K31/34 ,  A61K31/381 ,  A61K31/40 ,  A61K31/415 ,  A61K31/426

CPC classification number: C07D207/16 ,  C07C259/06 ,  C07C317/50 ,  C07C323/60 ,  C07D231/12 ,  C07D277/06 ,  C07D277/12 ,  C07D277/56 ,  C07D307/68 ,  C07D333/24

Abstract: Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) each indicates a point of attachment.

Abstract translation: 本文描述的是N-羟基酰胺抗菌化合物，制备该化合物的方法，含有这些化合物的药物组合物和利用该化合物治疗细菌感染的方法和药物组合物式（I）的化合物或其盐，溶剂化物ti水合物，其中A 是（a）每个表示一个附件点。

公开(公告)号：US08049562B2

公开(公告)日：2011-11-01

申请号：US12683431

申请日：2010-01-07

Applicant: Rakesh Kumar ,  Gireesh Rajendran ,  Rittu Sachdev Singh

Inventor： Rakesh Kumar ,  Gireesh Rajendran ,  Rittu Sachdev Singh

IPC: H03F3/45

CPC classification number: H03F3/45179 ,  H03F3/45475 ,  H03F3/45632 ,  H03F3/45928 ,  H03F2200/168 ,  H03F2200/411 ,  H03F2203/45512

Abstract: An amplifier includes a first pair of transistors (the first pair) that defines a first output, each transistor of the first pair having a gate coupled to a first input terminal; a second pair of transistors (the second pair) that defines a second output, each transistor of the second pair having a gate coupled to a second input terminal; a first capacitor coupled to the second output terminal and to the gate of a first transistor of the first pair; a second capacitor coupled to the second output terminal and to the gate of a second transistor of the first pair; a third capacitor coupled to the first output terminal and to the gate of a third transistor of the second pair; and a fourth capacitor coupled to the first output terminal and to the gate of a fourth transistor of the second pair.

Abstract translation: 放大器包括限定第一输出的第一对晶体管（第一对），第一对的每个晶体管具有耦合到第一输入端的栅极; 限定第二输出的第二对晶体管（第二对），第二对的每个晶体管具有耦合到第二输入端的栅极; 第一电容器，耦合到所述第二输出端子和所述第一对的第一晶体管的栅极; 耦合到所述第二输出端子和所述第一对的第二晶体管的栅极的第二电容器; 耦合到所述第一输出端子和所述第二对的第三晶体管的栅极的第三电容器; 以及耦合到所述第一输出端子和所述第二对的第四晶体管的栅极的第四电容器。