公开(公告)号：US20130303540A1

公开(公告)日：2013-11-14

申请号：US13991267

申请日：2011-12-02

Applicant: Antoni Torrens Jover ,  María Rosa Cuberes-Altisen

Inventor： Antoni Torrens Jover ,  María Rosa Cuberes-Altisen

IPC: C07D413/12 ,  A61K31/485 ,  A61K31/5377

CPC classification number: A61K31/535 ,  A61K31/485 ,  A61K31/5377 ,  C07D413/12

Abstract: The invention relates to pyrazole derivatives of formula I having pharmacological activity and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of pain.

Abstract translation: 本发明涉及具有药理活性的式I的吡唑衍生物及其制备方法，包括它们的药物组合物，以及它们在治疗和/或预防疼痛中的用途。

公开(公告)号：US20130302364A1

公开(公告)日：2013-11-14

申请号：US13884634

申请日：2011-11-10

Applicant: Beatriz Mothe Pujadas ,  Christian Brander ,  James I. Mullins

Inventor： Beatriz Mothe Pujadas ,  Christian Brander ,  James I. Mullins

IPC: A61K39/21

CPC classification number: A61K39/21 ,  A61K38/00 ,  A61K39/12 ,  A61K2039/572 ,  C07K7/08 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16222 ,  C12N2740/16234 ,  G01N33/505 ,  G01N2333/161

Abstract: The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.

Abstract translation: 本发明涉及包含部分或全部保护元件的肽，所述保守元件来源于由天然存在的HIV变异体编码的多肽家族的树中（COT）序列。 本发明还涉及包含所述肽的免疫原性组合物和疫苗。 本发明还涉及基于检测患者的T细胞以鉴定针对所述肽的细胞毒性T细胞应答以及用于鉴定变体多肽家族内的免疫原性肽的方法来鉴定HIV控制患者的方法。

公开(公告)号：US08501802B2

公开(公告)日：2013-08-06

申请号：US12991420

申请日：2009-05-20

Applicant: Helmut Heinrich Buschmann ,  Lluis Solá Carandell ,  Jordi Benet Buchholz ,  Jordi Carles Ceròn Bertran ,  Jesüs Ramirez Artero

Inventor： Helmut Heinrich Buschmann ,  Lluis Solá Carandell ,  Jordi Benet Buchholz ,  Jordi Carles Ceròn Bertran ,  Jesüs Ramirez Artero

IPC: A61K31/381 ,  C07D333/16

CPC classification number: A61K31/381 ,  A61K31/192 ,  C07D333/20

Abstract: The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract translation: 本发明涉及度洛西汀和选自COX-抑制剂的共晶体共晶体，其制备方法及其作为药物或药物制剂的用途，更特别是用于治疗疼痛。

公开(公告)号：US20130072456A1

公开(公告)日：2013-03-21

申请号：US13661965

申请日：2012-10-26

Applicant: Laboratorios del Dr. Esteve, S.A.

Inventor： Miguel Angel Pericas-Brondo ,  Antonio Torrens-Jover ,  Susana Yenes-Minguez ,  Felix Cuevas Cordobes ,  Carmen Garcia Granda

IPC: A61K31/403 ,  C07D209/52

CPC classification number: A61K31/403 ,  C07D209/52 ,  C07D209/94

Abstract: The present invention relates to substituted bicyclic tetrahydropyrrole compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

公开(公告)号：US08202872B2

公开(公告)日：2012-06-19

申请号：US12281313

申请日：2007-03-01

Applicant: Rosa Cuberes-Altisent ,  Joerg Holenz

Inventor： Rosa Cuberes-Altisent ,  Joerg Holenz

IPC: A61K31/496 ,  A61K31/454 ,  A61K31/437 ,  C07D401/12 ,  C07D221/00

CPC classification number: C07D401/12 ,  C07D231/22 ,  C07D403/12 ,  C07D471/04

Abstract: The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

Abstract translation: 本发明涉及具有对σ受体的药理学活性的式I化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中涉及σ受体的疾病的用途 。

公开(公告)号：US20120065167A1

公开(公告)日：2012-03-15

申请号：US13260156

申请日：2010-03-30

Applicant: David Sabate Elias ,  Josep M. Homedes Beguer ,  Pablo Gomez Ochoa

Inventor： David Sabate Elias ,  Josep M. Homedes Beguer ,  Pablo Gomez Ochoa

IPC: A61K31/454 ,  A61P33/00 ,  A61P37/00 ,  A61P31/12 ,  A61K31/519 ,  A61P37/08 ,  A61P31/22 ,  A61P31/14 ,  A61K31/661 ,  A61P33/02 ,  A61P11/06

CPC classification number: A61K31/454 ,  A61K31/685 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to the use of domperidone or a pharmaceutically acceptable salt thereof at low doses to prevent and/or treat a disease associated with an alteration of the immune response such as Leishmaniosis.

Abstract translation: 本发明涉及多潘立酮或其药学上可接受的盐在低剂量下的用途，以预防和/或治疗与诸如利什曼病之类的免疫应答的改变相关的疾病。

公开(公告)号：US08097641B2

公开(公告)日：2012-01-17

申请号：US12525461

申请日：2008-02-06

Applicant: Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut H. Buschmann

Inventor： Monica Garcia-Lopez ,  Antonio Torrens-Jover ,  Helmut H. Buschmann

IPC: A61K31/415 ,  C07D231/12

CPC classification number: C07D231/12 ,  C07D213/64 ,  C07D261/08

Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.

Abstract translation: 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。

公开(公告)号：US20110281848A1

公开(公告)日：2011-11-17

申请号：US13194434

申请日：2011-07-29

Applicant: Rosa CUBERES-ALTISENT ,  Joerg HOLENZ

Inventor： Rosa CUBERES-ALTISENT ,  Joerg HOLENZ

IPC: A61K31/55 ,  C07D231/38 ,  A61K31/5377 ,  C07D413/12 ,  A61K31/454 ,  C07D401/12 ,  A61K31/496 ,  C07D403/12 ,  A61P1/12 ,  A61P25/06 ,  A61P3/04 ,  A61P3/06 ,  A61P19/02 ,  A61P9/12 ,  A61P9/06 ,  A61P1/04 ,  A61P25/00 ,  A61P25/30 ,  A61P35/00 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P29/00 ,  A61P37/06 ,  A61K31/415

CPC classification number: C07D231/40

Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

Abstract translation: 本发明涉及式（I）化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。

公开(公告)号：US07964603B2

公开(公告)日：2011-06-21

申请号：US12175660

申请日：2008-07-18

Applicant: Jose Luis Diaz-Fernandez ,  Ramon Merce-Vidal ,  Lajos Novak

Inventor： Jose Luis Diaz-Fernandez ,  Ramon Merce-Vidal ,  Lajos Novak

IPC: A61K31/496 ,  C07D215/58

CPC classification number: A61K31/4709 ,  C07D215/38 ,  C07D215/58

Abstract: The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

Abstract translation: 本发明涉及通式（I）的取代的四氢 - 喹啉 - 磺酰胺化合物：其制备方法，包含这些化合物的药物以及取代的四氢 - 喹啉 - 磺酰胺化合物用于制备5-HT6的药物 受体调节以及与之相关的疾病的治疗。

公开(公告)号：US20110118253A1

公开(公告)日：2011-05-19

申请号：US12988929

申请日：2009-04-27

Applicant: Antoni Torrens Jover ,  Maria Rosa Cuberes-Altisent ,  Maria Jose Pretel Sanchez ,  Maria Magdelena Bordas Gelabert

Inventor： Antoni Torrens Jover ,  Maria Rosa Cuberes-Altisent ,  Maria Jose Pretel Sanchez ,  Maria Magdelena Bordas Gelabert

IPC: A61K31/5377 ,  C07D413/12 ,  C07D231/22 ,  A61K31/415 ,  A61P29/00 ,  A61P25/00

CPC classification number: C07D231/22

Abstract: The invention relates to compounds having the formula (I): wherein the dashed line (represented by - - - - -) represents an optional double bond; R1 is hydrogen and R2 is hydroxyethyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl ring optionally substituted with one or two hydroxy groups; each R3 is independently hydroxy or C1-6alkoxy; n is selected from 0, 1, and 2; or a N-oxide, salt, prodrug, solvate or stereoisomer thereof; with the proviso that the compound where the dashed line represents a double bond, R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl ring, and n is 0, is excluded. Also provided are methods for the preparation of compounds of formula (I); their uses as a medicaments, particularly for the treatment or prophylaxis of a sigma receptor mediated diseases or conditions.

Abstract translation: 本发明涉及具有式（I）的化合物：其中虚线（由 - - - - 表示）表示任选的双键; R1是氢，R2是羟乙基; 或R 1和R 2与它们所连接的氮原子一起形成任选被一个或两个羟基取代的吗啉基; 每个R 3独立地是羟基或C 1-6烷氧基; n选自0,1和2; 或其N-氧化物，盐，前药，溶剂合物或立体异构体; 条件是虚线表示双键的化合物，R 1和R 2与它们所连接的氮原子一起形成吗啉基环，n为0。 还提供了制备式（I）化合物的方法; 它们作为药物的用途，特别是用于治疗或预防σ受体介导的疾病或病症。