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    GLUE COMPOSITION FOR LUNG VOLUME REDUCTION
    12.
    发明申请
    GLUE COMPOSITION FOR LUNG VOLUME REDUCTION 有权
    用于肺容量减少的GLUE组合物

    公开(公告)号：US20110251136A1

    公开(公告)日：2011-10-13

    申请号：US13089496

    申请日：2011-04-19

    申请人： Glen Gong ,  Ronald Dieck

    发明人： Glen Gong ,  Ronald Dieck

    IPC分类号： A61K38/55 ,  A61P11/00

    CPC分类号： A61K38/55 ,  A61K38/57 ,  A61K47/6425 ,  A61K47/66 ,  A61K51/088 ,  B82Y5/00

    摘要： The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

    摘要翻译： 本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。 粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。 本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。

    Glue compositions for lung volume reduction
    13.
    发明授权
    Glue compositions for lung volume reduction 有权
    用于肺容积减少的胶组合物

    公开(公告)号：US07678767B2

    公开(公告)日：2010-03-16

    申请号：US11008087

    申请日：2004-12-08

    申请人： Glen Gong ,  Ronald Dieck

    发明人： Glen Gong ,  Ronald Dieck

    IPC分类号： A61K38/00 ,  C07K14/00

    CPC分类号： A61K38/57 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/106 ,  A61L24/108 ,  A61L2300/434 ,  A61L2400/06 ,  C08L89/00

    摘要： The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

    摘要翻译： 本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。 粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。 本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。

    Lung volume reduction devices, methods, and systems
    15.
    发明授权
    Lung volume reduction devices, methods, and systems 有权

    公开(公告)号：US10226257B2

    公开(公告)日：2019-03-12

    申请号：US15192142

    申请日：2016-06-24

    申请人： PneumRx, Inc.

    发明人： Mark L. Mathis ,  David Thompson ,  Nathan Aronson ,  Patrick Wu

    IPC分类号： A61B17/08 ,  A61B17/12 ,  A61M16/04 ,  A61M16/20 ,  A61B1/267 ,  A61B17/122 ,  A61B17/00 ,  A61F2/04

    摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

    Cross-sectional modification during deployment of an elongate lung volume reduction device
    19.
    发明授权
    Cross-sectional modification during deployment of an elongate lung volume reduction device 有权
    在展开细长的肺容积减小装置期间的横截面修改

    公开(公告)号：US09474533B2

    公开(公告)日：2016-10-25

    申请号：US14225892

    申请日：2014-03-26

    申请人： PneumRx, Inc.

    发明人： Mark L. Mathis ,  Patrick Wu ,  David Lehrberg ,  Jaime Vasquez ,  Erin McGurk ,  Ronald Dieck ,  Andrew Stein

    IPC分类号： A61F2/04 ,  A61B17/12 ,  A61B1/267 ,  A61B17/10 ,  A61B17/00

    CPC分类号： A61B17/12104 ,  A61B1/2676 ,  A61B17/10 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/04 ,  A61F2002/043

    摘要： Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

    摘要翻译： 细长的植入物结构可被引入到目标气道轴向区域的气道系统中，经常在气道内长时间施加横向弯曲和/或压缩力对肺组织。 植入物的结构或特征可以抑制组织反应，否则可能会使装置的部分最终穿过气道的壁。 这些装置可以增强在周围气道腔壁的组织上横向承受的面积。 实施例可以具有增加与气道的装置摩擦的特征，以允许装置在装置展开时夹紧周围气道。 可能在肺内的装置周围引入适当的粘合剂。 亲水材料可能抑制生物膜形成，或引起一些组织向内生长（刺激组织生长）的特征可以增强植入装置的支持。