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公开(公告)号：US20170009205A1
公开(公告)日：2017-01-12
申请号：US15106991
申请日：2014-12-24
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Pauline Maria Wilhelmina VAN HELDEN , Mark Jeroen KWAKKENBOS , Hergen SPITS , Tim BEAUMONT
IPC: C12N5/0781 , C07K16/10 , C12P21/00 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C07K16/1018 , C07K2317/14 , C12N15/86 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12N2740/13045 , C12N2810/6054 , C12P21/005
Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.
Abstract translation: 本发明提供用于生产具有短加倍时间的改进的离体B细胞培养物的方法和方法。
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公开(公告)号：US20160194382A1
公开(公告)日：2016-07-07
申请号：US15048339
申请日：2016-02-19
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim BEAUMONT , Mark Jeroen KWAKKENBOS , Hergen SPITS , Adrianus Quirinus BAKKER
IPC: C07K16/10
CPC classification number: C07K16/1027 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
Abstract: The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.
Abstract translation: 本发明提供用于调节抗体产生浆细胞样B细胞中体细胞超突变的发生的方法和方法。
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公开(公告)号：US09266943B2
公开(公告)日：2016-02-23
申请号：US14103715
申请日：2013-12-11
Applicant: Genentech, Inc. , AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US20200149007A1
公开(公告)日：2020-05-14
申请号：US16575518
申请日：2019-09-19
Applicant: AIMM THERAPEUTICS B.V.
IPC: C12N5/0781 , C12P21/00 , C07K16/10 , C07K16/00 , C12N15/86
Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.
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公开(公告)号：US20180292391A1
公开(公告)日：2018-10-11
申请号：US15900589
申请日：2018-02-20
Applicant: Genentech, Inc. , AIMM Therapeutics B.V.
Inventor： Tim BEAUMONT , Mark Jeroen KWAKKENBOS , Eric J. BROWN , John Hiroshi MORISAKI , Wouter L.W. HAZENBOS , Sanjeev MARIATHASAN , Kimberly KAJIHARA , Yi XIA
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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Patent Agency Ranking
公开(公告)号：US10077427B2
公开(公告)日：2018-09-18
申请号：US14669916
申请日：2015-03-26
Inventor： Hergen Spits
IPC: C12N5/06 , C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US09927428B2
公开(公告)日：2018-03-27
申请号：US15246301
申请日：2016-08-24
Applicant: Genentech, Inc. , AIMM Therapeutics B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US09822339B2
公开(公告)日：2017-11-21
申请号：US14836335
申请日：2015-08-26
Inventor： Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
IPC: A61K38/00 , C12N15/63 , C12N5/18 , C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/231 , C12N2501/2321 , C12N2501/52 , C12N2501/60 , C12N2502/99 , C12N2510/02 , C12N2510/04
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20170306293A1
公开(公告)日：2017-10-26
申请号：US15612096
申请日：2017-06-02
Inventor： HERGEN SPITS , FERENC A. SCHEEREN , TIM BEAUMONT , SEAN A. DIEHL
IPC: C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/231 , C12N2501/2321 , C12N2501/52 , C12N2501/60 , C12N2502/99 , C12N2510/02 , C12N2510/04
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20170008952A1
公开(公告)日：2017-01-12
申请号：US15113563
申请日：2015-01-30
Applicant: AIMM THERAPEUTICS B.V
Inventor： Mark Jeroen KWAKKENBOS , Koen WAGNER , Adrianus Quirinus BAKKER
CPC classification number: C07K16/1018 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12Q1/6869
Abstract: The invention provides means and methods for selecting and producing stable antibodies against an antigen of interest, using stable ex vivo B cell cultures.
Abstract translation: 本发明提供了使用稳定的离体B细胞培养物选择和产生针对感兴趣抗原的稳定抗体的方法和方法。
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