公开(公告)号：US20140072608A1

公开(公告)日：2014-03-13

申请号：US14015530

申请日：2013-08-30

Applicant: Varvara KARAGKIOZAKI ,  Stergios LOGOTHETIDIS ,  Greek Aristotle University of Thessaloniki- Research Committee

Inventor： Stergios LOGOTHETIDIS ,  Varvara KARAGKIOZAKI

IPC: A61K9/70

Abstract: The present invention relates to the design and development of a drug delivery nanoplatform that consists of nanoporous, multi-layer biodegradable polymeric (BP) thin films for controlled release of its payload. The method is used notably to synthesize nanoporous BP coatings as drug delivery vehicles exhibiting uniform nanopores with tailored characteristics for control of drug delivery and release. It enables the multiplex delivery of drugs that can be eluted at desirable time intervals in line with each medical need. Atomic Force Microscopy and Spectroscopic Ellipsometry are applied for determining nanoporosity, thickness, drug loading, structural properties, and quality of the BP films ensuring the quality control of the final product. The complete degradation of the polymers minimizes the toxicity within the human body and such nanoplatform can be used in a wide range of drug eluting and other medical implants and biomedical devices.

Abstract translation: 本发明涉及由纳米多孔，多层可生物降解聚合物（BP）薄膜组成的药物递送纳米平台的设计和开发，用于控制其有效载荷的释放。 该方法特别用于合成纳米多孔BP涂层，作为具有用于控制药物递送和释放的定制特征的均匀纳米孔的药物递送载体。 它能够多次递送可按所需时间间隔洗脱的药物，以符合每项医疗需要。 原子力显微镜和光谱椭偏仪用于确定最终产品的质量控制的BP膜的纳米孔隙度，厚度，药物负载，结构特性和质量。 聚合物的完全降解最小化了人体内的毒性，并且这种纳米平台可用于广泛的药​​物洗脱和其它医疗植入物和生物医学装置。

公开(公告)号：US20240388819A1

公开(公告)日：2024-11-21

申请号：US18635483

申请日：2024-04-15

Applicant: ARISTOTLE UNIVERSITY OF THESSALONIKI - E.L.K.E. (Eidikos Logariasmos Kondilion Erevnas)

Inventor： Nikolaos Pleros ,  Ronis Maximidis ,  Apostolos Tsakyridis ,  Miltiadis Moralis-Pegios ,  Georgios Giamougiannis

IPC: H04Q11/00 ,  G02B6/35

Abstract: Optical beamforming device for multiple beams incorporating a universal optical linear crossbar architecture by means whereof the beams are controlled independently in terms of their amplitude and phase, remarkable in that it comprises a photonic crossbar linear optical circuit architecture comprising a coherent multiport interferometer on which it relies; and method for carrying out said device wherein an 1: N splitter (1) followed by N e/o modulators (2) provides N parallel optical signals that get subsequently launched into the Xbar matrix, with every signal entering through a respective waveguide row. Each row employs an optical coupling stage to every matrix column, so that part of the modulated optical signal gets forwarded into the respective column, the remaining part continues to the next column. The intra-column beams are then entering respective Variable Amplitude and Phase (VAP) modulation blocks designed as forming Xbar nodes (4), with each of them comprising an optical amplitude modulator followed by a phase modulator, thus generating the amplitude and phase adjustment of the propagating beam. After exiting the Xbar node, the intra-column optical beams are forced to coherently recombine in a N:1 recombination stage comprising a binary tree of 3 dB-couplers. More specifically, the N signals recombine sequentially in clusters of two at every combination stage until reaching the single waveguide output connected to a radiating element. This leads to the radiation from every i-th column of a sum of N orthogonal modulated amplitude-and phase-adjusted optical sub-signals The over-the-air combination of M radiated signals each consisting of N orthogonal signals leads to the generation of N radiating beams with each beam generated by an algebraic summation of orthogonal modulated sub-signals corresponding to every input port.

公开(公告)号：US20240315709A1

公开(公告)日：2024-09-26

申请号：US18575721

申请日：2022-06-30

Applicant: ARISTOTLE UNIVERSITY OF THESSALONIKI-E.L.K.E. (Eidikos Logariasmos Kondilion Erevnas)

Inventor： Konstantinos Ditsios

IPC: A61B17/17 ,  A61B17/15 ,  A61B17/88

CPC classification number: A61B17/1739 ,  A61B17/151 ,  A61B17/1796 ,  A61B17/8861

Abstract: The invention relates to the application of the tension-band-aiming device for olecranon fracture osteosynthesis. The device may also be used in cases where osteotomy of the olecranon is needed. It comprises a main part and five other adjuvant elements one of which assists for the osteotomy. The device offers precision for optimal results and is easy to use. The invention also relates to a method for the application of the tension-band-aiming device for olecranon fracture osteosynthesis and to its use.

公开(公告)号：US11971185B2

公开(公告)日：2024-04-30

申请号：US16792936

申请日：2020-02-18

Applicant: Aristotle University of Thessaloniki—Research Committee E.L.K.E.

Inventor： Christos Mademlis ,  Nikolaos Jabbour ,  Evangelos Tsioumas

IPC: F24F11/47 ,  F24F11/50 ,  F24F11/88 ,  G05B19/04 ,  G05F1/66 ,  H02J3/00 ,  H02J7/00

CPC classification number: F24F11/47 ,  F24F11/50 ,  F24F11/88 ,  G05B19/0405 ,  G05F1/66 ,  H02J3/004 ,  H02J7/0048 ,  H02J7/0063 ,  G05B2219/2202 ,  G05B2219/2614 ,  G05B2219/2642 ,  H02J2310/12 ,  H02J2310/60 ,  H02J2310/64

Abstract: An optimal energy management method and a system that implements the method for a nearly zero energy building (nZEB) based on the genetic algorithm technique that can provide an optimal balance between the objectives of energy saving, comfort of the building residents and maximum exploitation of the generated electric energy by the renewable energy sources through the proper utilization of a battery storage system, is developed in this invention. The above can be attained by minimizing a cost function that considers the real-time electricity price, the generated/consumed electric energy by each device, the user preferences, the state-of-charge and the energy price of the battery storage system (BSS), and the weather forecast. the system that implements the optimal energy management method comprises energy and temperature sensors, controllable power switches, a battery storage system and a controller with human machine interface. The outcomes of the energy management system are control signals that regulate the operation of the power switches and the inverter of the battery storage system.

公开(公告)号：US20230408399A1

公开(公告)日：2023-12-21

申请号：US18251275

申请日：2021-10-29

Applicant: ARISTOTLE UNIVERSITY OF THESSALONIKI - E.L.K.E. ,  HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

Inventor： Leonidas Ntziachristos ,  Nikolaos Kousias ,  Vasilis Ntziachristos ,  Anastasios Kontses ,  Antonios Stylogiannis

IPC: G01N21/17 ,  G01N21/31

CPC classification number: G01N21/171 ,  G01N21/3103 ,  G01N2201/0221 ,  G01N2021/4704

Abstract: An apparatus for photo-acoustic measurement of a measurement target in a fluid flow comprises:—an ellipsoidal measurement chamber (3) having a first focal point and a second focal point; —a duct (6, 7, 8) configured to guide a fluid flow through the measurement chamber (3) along a first axis (X) through the first focal point; —light source means for generating an excitation light beam of modulated intensity; —means configured to pass the excitation light beam through the measurement chamber (3) along a second axis (Y), which is different from the first axis (X), such that the excitation light beam crosses the fluid flow at the first focal point and that the crossing of the fluid flow and the excitation light beam defines an excitation volume (4) within which the fluid flow is excited by the excitation light beam to generate acoustic waves; and —detecting means (5) arranged at the second focal point and configured to detect said acoustic waves, wherein the detecting means has no direct contact with the fluid flow, and wherein the ellipsoidal measurement chamber has inner walls that are configured to focus the acoustic waves generated by the excitation light beam within the excitation volume (4) onto the detecting means (5).

公开(公告)号：US20220236619A1

公开(公告)日：2022-07-28

申请号：US17617603

申请日：2019-06-10

Applicant: Mellanox Technologies, Ltd. ,  ETH ZURICH ,  ARISTOTLE UNIVERSITY OF THESSALONIKI

Inventor： Claudia Hoessbacher ,  Juerg Leuthold ,  Elad Mentovich ,  Paraskevas Bakopoulos ,  Dimitrios Kalavrouziotis ,  Dimitrios Tsiokos

IPC: G02F1/225 ,  G02F1/21

Abstract: An optoelectronic device (20) includes thin film structures (56) disposed on a semiconductor substrate (54) and patterned to define components of an integrated drive circuit, which is configured to generate a drive signal. A back end of line (BEOL) stack (42) of alternating metal layers (44, 46) and dielectric layers (50) is disposed over the thin film structures. The metal layers include a modulator layer (48), which contains a plasmonic waveguide (36, 99, 105) and a plurality of electrodes (30, 32, 34, 96, 98, 106), which apply a modulation to surface plasmons polaritons (SPPs) propagating in the plasmonic waveguide in response to the drive signal. A plurality of interconnect layers are patterned to connect the thin film structures to the electrodes. An optical input coupler (38, 82) is configured to couple light into the modulator layer, whereby the light is modulated by the modulation of the SPPs, and an optical output coupler (38, 82) is configured to couple the modulated light out of the modulator layer.

公开(公告)号：US11204326B2

公开(公告)日：2021-12-21

申请号：US16486871

申请日：2018-02-20

Applicant: Aristotle University of Thessaloniki-Research Committee E.L.K.E. ,  AMO GmbH Gesellschaft für Angewandte Mikro- und Optoelektronic Mit Beschränkter Haftung

Inventor： Nikolaos Pleros ,  Dimitrios Tsiokos ,  Georgios Ntampos ,  Dimitra Ketzaki ,  Anna-Lena Giesecke

IPC: G01N21/77 ,  G02B6/12 ,  G01N1/22 ,  G02B6/122

Abstract: The invention relates to a device comprising a first optical Mach-Zehnder interferometric sensor (MZI1) with a large FSR, wherein a plasmonic waveguide (107) thin-film or hybrid slot, is incorporated as transducer element planar integrated on Si3N4 photonic waveguides and a second optical interferometric Mach-Zehnder (MZI2), both comprising thermo-optic phase shifters (104, 106) for optimally biasing said MZI sensor (MZI1) and MZI as variable optical attenuator VOA. It further comprises an overall chip (112), being remarkable in that it comprises a set of Photonic waveguides (103) with a high index silicon nitride strip (303, 603), which is sandwiched between a low index oxide substrate (SiO2) and a low index oxide superstrate (LTO); Optical coupling structures (102, 109) at both ends of the sensor acting as the optical I/Os; an Optical splitter (102) and an optical combiner (109) for optical splitting at the first junction (102) of said first sensor (MZI1) and optical combining at the second junction (109) of said first MZI (MZI1); a variable optical attenuator (VOA) with said additional second MZI (MZI2), which is nested into said MZI1 (sensor)), deploying an optical splitter and an optical combiner for optical splitting at the first junction of said additional second MZI (MZI2), and optical combining at the second junction of said second MZI (MZI2); a set of Thermo-optic phase shifters (104, 106) to tune the phase of the optical signal in the reference arm (104, 106) of each said MZI (MZI1, MZI2-VOA); wherein Thermo-optic phase shifters are formed by depositing two metallic stripes parallel to each other on top of a section of the photonic waveguide and along the direction of propagation of light; and a plasmonic waveguide (107) in the upper branch (103) of said first MZI (MZI1), that confines light propagation through coupling to Surface Plasmon Polaritons (SPP) at the metal-analyte interface, and method associated thereto.