公开(公告)号：US20130296725A1

公开(公告)日：2013-11-07

申请号：US13829650

申请日：2013-03-14

申请人： Kichang LEE ,  Brian J. Wenzel ,  Jin Jiang ,  Stephen P. Hanlon

发明人： Kichang LEE ,  Brian J. Wenzel ,  Jin Jiang ,  Stephen P. Hanlon

IPC分类号： A61B5/06

CPC分类号： A61B34/20 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0456 ,  A61B5/061 ,  A61B5/065 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/488 ,  A61B2034/2063

摘要： Described herein are systems, devices and methods to increase the accuracy of intravascular catheter placement, and to improve electrocardiogram (ECG), intravascular electrogram, and ultrasound Doppler signal processing to detect the Superior Vena Cava (SVC) area. Embodiments of the invention are intended to place an intravascular catheter within the lower ⅓ of SVC to the junction of the SVC and the right atrium (RA)—called the cavoatrial junction (CAJ). In particular, the improved accuracy of CAJ location detection during an intravascular catheter placement can be provided by optimization of ECG parameters and ultrasound Doppler signal using Neuro-Fuzzy logic and/or other processing techniques.

摘要翻译： 本文描述了提高血管内导管放置准确度以及改善心电图（ECG），血管内电描记图和超声多普勒信号处理以检测上腔静脉（SVC）区域的系统，装置和方法。 本发明的实施例旨在将SVC的下1/3中的血管内导管置于SVC和右心房（RA）的接合处，以将气腔连接处（CAJ）联接。 特别地，可以通过使用神经 - 模糊逻辑和/或其他处理技术优化ECG参数和超声多普勒信号来提供血管内导管放置期间CAJ位置检测的改进的准确度。

公开(公告)号：US20130296693A1

公开(公告)日：2013-11-07

申请号：US13829522

申请日：2013-03-14

申请人： Brian J. WENZEL ,  Kichang Lee ,  Stephen P. Hanlon ,  Miroslav Navratil ,  Jin Jiang

发明人： Brian J. WENZEL ,  Kichang Lee ,  Stephen P. Hanlon ,  Miroslav Navratil ,  Jin Jiang

IPC分类号： A61B8/08

CPC分类号： A61B34/20 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0456 ,  A61B5/061 ,  A61B5/065 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/488 ,  A61B2034/2063

摘要： A method for determining the location of a medical device within a body is provided. The method includes transmitting from the medical device an acoustic signal; receiving with the medical device a reflected acoustic signal; advancing the medical device based on a first algorithm, the first algorithm including a first weighting factor and a first feature extracted from the reflected acoustic signal; determining a first location of the medical device based on the first algorithm; and moving the medical device to a second location based on a second algorithm, the second algorithm based on the determined first location and including at least one of a second weighting factor and a second feature extracted from the reflected acoustic signal. Also disclosed are systems and devices for performing the methods described herein.

摘要翻译： 提供了一种用于确定身体内的医疗装置的位置的方法。 该方法包括从医疗装置发送声信号; 用医疗装置接收反射的声信号; 基于第一算法推进医疗装置，第一算法包括从反射的声信号中提取的第一加权因子和第一特征; 基于所述第一算法确定所述医疗设备的第一位置; 并且基于第二算法将所述医疗装置移动到第二位置，所述第二算法基于所确定的第一位置并且包括从所述反射的声信号中提取的第二加权因子和第二特征中的至少一个。 还公开了用于执行本文所述方法的系统和装置。

公开(公告)号：US08396555B2

公开(公告)日：2013-03-12

申请号：US12490611

申请日：2009-06-24

申请人： Joseph W. Boggs, II ,  Brian J. Wenzel ,  Kenneth J. Gustafson ,  Warren M. Grill

发明人： Joseph W. Boggs, II ,  Brian J. Wenzel ,  Kenneth J. Gustafson ,  Warren M. Grill

IPC分类号： A61N1/36

CPC分类号： A61N1/36196 ,  A61N1/36007 ,  A61N1/37247

摘要： Apparatus to control physiological functions, including urinary track physiological functions are described. The apparatus includes an electrode(s) configured to be placed on or in a targeted component of a pudendal nerve and to stimulate the targeted pudendal nerve pudendal. The targeted component of the pudendal nerve includes a pudendal nerve urethral afferent, and afferent nerve fibers in the deep perineal nerve. The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude and a selected frequency chosen to stimulate the targeted component. The controller operates in a first mode to apply a first frequency without substantially changing the amplitude for achieving a first physiologic response and the controller operates in a second mode to apply a second frequency, different than the first frequency, for achieving a second physiologic response different than the first physiologic response.

摘要翻译： 描述了用于控制生理功能的装置，包括尿道生理功能。 该装置包括构造成放置在阴部神经的目标部件上或其中的电极，并刺激目标阴部神经阴部。 阴部神经的目标成分包括阴部神经尿道传入和深会阴神经中的传入神经纤维。 该装置包括耦合到电极的控制器，以施加具有选择的振幅和选定频率的电信号，以刺激目标成分。 控制器以第一模式操作以施加第一频率而基本上不改变幅度以实现第一生理响应，并且控制器以第二模式操作以施加与第一频率不同的第二频率，以实现不同于第二频率的第二生理响应 比第一次生理反应。

公开(公告)号：US07571000B2

公开(公告)日：2009-08-04

申请号：US11402036

申请日：2006-04-11

申请人： Joseph W. Boggs, II ,  Brian J. Wenzel ,  Kenneth J. Gustafson ,  Warren M. Grill

发明人： Joseph W. Boggs, II ,  Brian J. Wenzel ,  Kenneth J. Gustafson ,  Warren M. Grill

IPC分类号： A61N1/36

CPC分类号： A61N1/36196 ,  A61N1/36007 ,  A61N1/37247

摘要： Apparatus for control of physiological functions, including physiological functions of the urinary tract, using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve, and/or its branch(es), and/or its spinal root(s). The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude to the electrode at a selected frequency to stimulate the targeted component. The controller operates in a first mode to apply a first frequency or range of frequencies without substantially changing the amplitude for achieving a first physiologic response (e.g., controlling urinary continence) and the controller operates in a second mode to apply a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).

摘要翻译： 用于控制生理功能的装置，包括尿道的生理功能，使用至少一个尺寸和构造为位于阴部神经和/或其分支的目标组分中，附近或附近的电极和/或其分支，以及 /或其脊髓根部。 该装置包括耦合到该电极的控制器，以一选定频率将具有振幅的电信号施加到该电极上以刺激该目标部件。 控制器以第一模式操作以施加第一频率或频率范围，而基本上不改变振幅以实现第一生理响应（例如，控制尿路），并且控制器以第二模式操作以施加第二频率或范围 频率，不同于第一频率，用于实现与第一生理反应不同的第二生理反应（例如，控制排尿）。

公开(公告)号：US06442408B1

公开(公告)日：2002-08-27

申请号：US09669781

申请日：2000-09-25

申请人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

发明人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

IPC分类号： A61B500

CPC分类号： A61B5/441 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01N21/274 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49

摘要： An apparatus and method for non-invasively quantifying the hydration of the stratum corneum of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting NIR absorption spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, a calibration model developed from an exemplary set of measurements is applied to predict the SC hydration for the sample. The method of SC hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. The stratum corneum hydration measurement is therefore suitable for further spectral analysis and the quantification of biological and chemical compounds, such as blood analytes.