公开(公告)号：US06587196B1

公开(公告)日：2003-07-01

申请号：US09491350

申请日：2000-01-26

申请人： Tim Stippick ,  George Acosta ,  Ken Meissner

发明人： Tim Stippick ,  George Acosta ,  Ken Meissner

IPC分类号： G01J306

CPC分类号： G01J3/06

摘要： The invention provides a mechanism for oscillating the spectral grating of a monochromator. The mechanism couples the spectral grating of the monochromator to an oscillating spatial linkage mechanism which accepts a rotational input and converts it into an oscillatory motion. A monochromator according to the invention comprises an oscillating grating that is oscillated by such spacial linkage mechanism drive.

摘要翻译： 本发明提供一种用于振荡单色仪的光谱光栅的机构。 该机构将单色仪的光谱光栅耦合到接受旋转输入并将其转换为振荡运动的振荡空间连杆机构。 根据本发明的单色仪包括通过这种空间连杆机构驱动振荡的振荡光栅。

公开(公告)号：US06668181B2

公开(公告)日：2003-12-23

申请号：US10161197

申请日：2002-05-31

申请人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

发明人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

IPC分类号： A61B500

CPC分类号： A61B5/441 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01N21/274 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49

摘要： An apparatus and method for non-invasively quantifying the hydration of the stratum corneum of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting NIR absorption spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, a calibration model developed from an exemplary set of measurements is applied to predict the SC hydration for the sample. The method of SC hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. The stratum corneum hydration measurement is therefore suitable for further spectral analysis and the quantification of biological and chemical compounds, such as blood analytes.

公开(公告)号：US06442408B1

公开(公告)日：2002-08-27

申请号：US09669781

申请日：2000-09-25

申请人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

发明人： Brian J. Wenzel ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Ken Meissner ,  Frank Grochocki ,  Thomas Blank ,  Jessica Rennert

IPC分类号： A61B500

CPC分类号： A61B5/441 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01N21/274 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49

摘要： An apparatus and method for non-invasively quantifying the hydration of the stratum corneum of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting NIR absorption spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, a calibration model developed from an exemplary set of measurements is applied to predict the SC hydration for the sample. The method of SC hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. The stratum corneum hydration measurement is therefore suitable for further spectral analysis and the quantification of biological and chemical compounds, such as blood analytes.