Abstract:
The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
Abstract:
A hinge assembly for a wireless communication device that pivotally connects a display housing member to a keypad housing member is described. The hinge assembly comprises an upper hinge arm, a lower hinge arm, and a rotating assembly. The upper hinge arm includes an upper hinge plate that is coupled to the display housing member. The lower hinge arm includes a lower hinge plate that is coupled to the keypad housing member. The rotating assembly comprises a first fastener, a second fastener and at least one conductive spring. The first fastener couples the upper hinge arm to one end of the rotating assembly. The second fastener couples the lower hinge arm to the other end of the rotating assembly. At least one conductive spring interfaces with at least one hinge end, and provides a ground path within the hinge assembly.
Abstract:
The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
Abstract:
An automated banking machine system and method includes ATMs which accept checks and dispense cash to users. The ATMs are operated to acquire image and magnetic data from deposited checks to determine the genuineness of checks and the authority of a user to receive cash for such checks. Cash may be dispensed to the user from the ATM in exchange for the deposited check. The ATMs dispense cash responsive to communications with a transaction host.
Abstract:
An automated banking machine system and method includes ATMs which accept checks and dispense cash to users. The ATMs are operated to acquire image and magnetic data from deposited checks to determine the genuineness of checks and the authority of a user to receive cash for such checks. Cash may be dispensed to the user from the ATM in exchange for the deposited check. The ATMs dispense cash responsive to communications with a transaction host.
Abstract:
A package and plurality of golf balls customized for an individual including an enclosure formed of a material suitable for printing thereon; and a plurality of golf balls disposed therein; the enclosure including a top portion, a bottom portion, and a plurality of side portions joining the top and bottom portions, wherein at least one of the top, bottom, or side portions include an image of the individual's business card.
Abstract:
A method and apparatus for performing pipelined computations that include cross-iteration computations. The apparatus includes a functional unit having at least one input and an output, each input being operable to receive an input data value and an associated input data validity tag indicative of the validity of the input data value and the output being operable to provide an output data value and an associated output data validity tag indicative of the validity of the output data value. The first functional unit is operable in a first mode in which an output data value from the first functional unit is valid if all of the input data values are valid, and in a second mode in which the output data value from the first functional unit is valid if any of the input data values is valid.
Abstract:
Substituted bicyclic heteroaryls having the following formula where the variables are as defined herein, and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110□ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
Abstract translation:具有下式的取代的双环杂芳基,其中变量如本文所定义,以及含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣, 包括但不限于自身免疫性疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血, 包括所有形式的超敏反应的过敏症状本发明还使得能够治疗依赖于p110□活性或与p110□活性相关的癌症的方法,包括但不限于白血病,例如急性骨髓性白血病(AML)Myelo-dysplastic sy (MDS)骨髓增生性疾病(MPD)慢性骨髓性白血病(CML)T细胞急性淋巴细胞性白血病(T-ALL)B细胞急性淋巴细胞性白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和 实体肿瘤,如乳腺癌。
Abstract:
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.