公开(公告)号：US5929084A

公开(公告)日：1999-07-27

申请号：US860524

申请日：1997-06-27

Applicant: Dayuan Zhu ,  Xican Tang ,  Jinlai Lin ,  Cheng Zhu ,  Jingkang Shen ,  Guansong Wu ,  Shanhao Jiang ,  Takuji Yamaguchi ,  Kazuhiro Tanaka ,  Takeshi Wakamatsu ,  Hiroaki Nishimura

Inventor： Dayuan Zhu ,  Xican Tang ,  Jinlai Lin ,  Cheng Zhu ,  Jingkang Shen ,  Guansong Wu ,  Shanhao Jiang ,  Takuji Yamaguchi ,  Kazuhiro Tanaka ,  Takeshi Wakamatsu ,  Hiroaki Nishimura

IPC: A61K31/435 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4748 ,  A61K36/18 ,  A61P21/00 ,  A61P25/28 ,  C07D221/22 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D221/06

CPC classification number: C07D401/06 ,  C07D221/22 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

Abstract: The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is ##STR1## or R" and Y together form .dbd.CH; R is (C.sub.1 -C.sub.5) alkyl, ##STR2## wherein n is 0 or 1, X is H, (C.sub.1 -C.sub.5) alkyl; (C.sub.1 -C.sub.5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C.sub.1 -C.sub.5) alkyl; --(CH.sub.2).sub.m COOZ, wherein m=0-5, Z is H or (C.sub.1 -C.sub.5) alkyl; --CH.dbd.CH--G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C.sub.1 -C.sub.5) alkyl at the nitrogen atom; R' is H, (C.sub.1 -C.sub.5) alkyl, pyridoyl, benzoyl substituted by (C.sub.1 -C.sub.5) alkyloxy; R" is H or (C.sub.1 -C.sub.5) alkyl; processes for their use as acetylcholinesterase inhibitor. ##STR3##

Abstract translation: PCT No.PCT / CN95 / 00100 Sec。 371日期：1997年6月27日 102（e）日期1997年6月27日PCT提交1995年12月26日PCT公布。 公开号WO96 / 20176 日期：1996年7月4日本发明涉及式（Ⅱ）的新型石杉碱甲衍生物，其中Y为或R“和Y一起形成= CH; R为（C 1 -C 5）烷基，其中n为0或1，X为H，（C 1 -C 5）烷基; （C1-C5）烷氧基; 硝基，卤素，羧基，烷氧基羰基，羟甲基，羟基，被双 - （C 1 -C 5）烷基取代的氨基; - （CH 2）m COOZ，其中m = 0-5，Z是H或（C 1 -C 5）烷基; -CH = CH-G，其中G是苯基，呋喃基，羧基，烷氧基羰基; 在氮原子被（C 1 -C 5）烷基取代的二氢或四氢吡啶基; R'是H，（C1-C5）烷基，吡啶基，（C1-C5）烷氧基取代的苯甲酰基; R“是H或（C 1 -C 5）烷基; 它们用作乙酰胆碱酯酶抑制剂的方法。

公开(公告)号：US20110083719A1

公开(公告)日：2011-04-14

申请号：US12999254

申请日：2009-06-24

Applicant: Harumi Takada ,  Masahiro Morooka ,  Reiko Yoneya ,  Masaki Orihashi ,  Cheng Zhu ,  Yusuki Suzuki ,  Kazuhiro Noda

Inventor： Harumi Takada ,  Masahiro Morooka ,  Reiko Yoneya ,  Masaki Orihashi ,  Cheng Zhu ,  Yusuki Suzuki ,  Kazuhiro Noda

IPC: H01L31/12

CPC classification number: H01G9/2068 ,  H01G9/2031 ,  H01G9/2059 ,  H01M10/46 ,  H02S40/38 ,  Y02E10/542

Abstract: The present invention relates to an electronic device configured to make use of features in terms of design quality and flexibility of a dye-sensitized solar cell. A solar cell-cum-display unit 61 has both a function of a solar cell and a function of a display unit that displays a predetermined display body, allows a predetermined character string such as “PONY” to be indentified, generates electric power from illuminating light or sunlight, and stores the electric power in a storage battery 62. A light source 63 such as a fluorescent lamp radiates light to the solar cell-cum-display unit 61 by the electric power stored in the storage battery 63, whereby the features of the dye-sensitized solar cell can be made use of. The present invention is applicable to a device including a dye-sensitized solar cell.

Abstract translation: 本发明涉及一种电子设备，其被配置为利用染料敏化太阳能电池的设计质量和灵活性方面的特征。 太阳能电池和显示单元61具有太阳能电池的功能和显示预定显示体的显示单元的功能，允许诸如“PONY”之类的预定字符串被识别，从照明中产生电力 光或阳光，并且将电力存储在蓄电池62中。诸如荧光灯的光源63通过存储在蓄电池63中的电力将光辐射到太阳能电池并行显示单元61，由此， 的染料敏化太阳能电池可以使用。 本发明可应用于包括染料敏化太阳能电池的装置。

公开(公告)号：US07858629B2

公开(公告)日：2010-12-28

申请号：US12226048

申请日：2007-04-10

Applicant: Richard Berger ,  Scott Edmondson ,  Alexa Hansen ,  Cheng Zhu

Inventor： Richard Berger ,  Scott Edmondson ,  Alexa Hansen ,  Cheng Zhu

IPC: A61K31/496 ,  A61K31/4709 ,  A61K31/454 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14

Abstract: Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

公开(公告)号：US20090253705A1

公开(公告)日：2009-10-08

申请号：US12417239

申请日：2009-04-02

Applicant: Richard Berger ,  Lehua Chang ,  Scott D. Edmondson ,  Stephen D. Goble ,  Sookhee Nicole Ha ,  Nam Fung Kar ,  Ihor E. Kopka ,  Bing Li ,  Gregori J. Morriello ,  Chris R. Moyes ,  Dong-Ming Shen ,  Liping Wang ,  Cheng Zhu

Inventor： Richard Berger ,  Lehua Chang ,  Scott D. Edmondson ,  Stephen D. Goble ,  Sookhee Nicole Ha ,  Nam Fung Kar ,  Ihor E. Kopka ,  Bing Li ,  Gregori J. Morriello ,  Chris R. Moyes ,  Dong-Ming Shen ,  Liping Wang ,  Cheng Zhu

IPC: A61K31/506 ,  C07D417/12 ,  C07D403/12 ,  C07D495/04 ,  C07D401/12 ,  A61K31/427 ,  A61K31/428 ,  A61K31/517 ,  A61K31/501 ,  A61K31/502 ,  A61K31/4439 ,  A61K31/41 ,  A61K31/437 ,  A61P13/10

CPC classification number: C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Abstract translation: 本发明提供式（I）的化合物，其药物组合物及其用于治疗或预防由β3肾上腺素受体激活介导的疾病的方法。

公开(公告)号：US20120141393A1

公开(公告)日：2012-06-07

申请号：US13305961

申请日：2011-11-29

Applicant: Xiaoxia Yang ,  Jun-Cheng Zhu

Inventor： Xiaoxia Yang ,  Jun-Cheng Zhu

IPC: A61K8/49 ,  A61Q19/04

CPC classification number: A61K8/4913 ,  A61K8/35 ,  A61K8/492 ,  A61Q19/04

Abstract: Described are compositions and methods for imparting a sunless tan with functionalized adjuvants and a tanning agent like dihydroxyacetone. The functionalized adjuvants are pyrrole and/or indole derivatives functionalized with a substituent comprising a carbonyl group.

Abstract translation: 描述了用功能化佐剂和鞣制剂如二羟基丙酮赋予无阳光褐变的组合物和方法。 功能化佐剂是用包含羰基的取代基官能化的吡咯和/或吲哚衍生物。

公开(公告)号：US20110028461A1

公开(公告)日：2011-02-03

申请号：US12936275

申请日：2009-03-23

Applicant: Richard Berger ,  Lehua Chang ,  Scott D. Edmondson ,  Stephen D. Goble ,  Bart Harper ,  Nam Fung Kar ,  Ihor E. Kopka ,  Bing Li ,  Gregori J. Morriello ,  Chris R. Moyes ,  Dong-Ming Shen ,  Liping Wang ,  Harvey Wendt ,  Cheng Zhu

Inventor： Richard Berger ,  Lehua Chang ,  Scott D. Edmondson ,  Stephen D. Goble ,  Bart Harper ,  Nam Fung Kar ,  Ihor E. Kopka ,  Bing Li ,  Gregori J. Morriello ,  Chris R. Moyes ,  Dong-Ming Shen ,  Liping Wang ,  Harvey Wendt ,  Cheng Zhu

IPC: A61K31/4439 ,  C07D417/14 ,  A61K31/502 ,  C07D413/14 ,  A61K31/5355 ,  A61P13/00 ,  A61P13/10

CPC classification number: C07D417/14 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D495/04

Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

Abstract translation: 本发明提供式I化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。

公开(公告)号：US20090281117A1

公开(公告)日：2009-11-12

申请号：US12226115

申请日：2007-04-10

Applicant: Joseph L. Duffy ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

Inventor： Joseph L. Duffy ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

IPC: A61K31/497 ,  C07D403/06 ,  C07D405/14

CPC classification number: C07D233/90 ,  C07D403/04 ,  C07D405/04

Abstract: Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

Abstract translation: 某些新型取代的咪唑4-甲酰胺是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

公开(公告)号：US20090118300A1

公开(公告)日：2009-05-07

申请号：US12225906

申请日：2007-04-10

Applicant: Richard Berger ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

Inventor： Richard Berger ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

IPC: A61K31/496 ,  C07D403/06 ,  A61P3/04 ,  A61K31/454 ,  C07D401/06

CPC classification number: C07D401/06 ,  C07D403/06 ,  C07D405/14

Abstract: Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

Abstract translation: 某些新型取代的咪唑4-甲酰胺是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

公开(公告)号：US6080012A

公开(公告)日：2000-06-27

申请号：US372659

申请日：1999-08-11

Applicant: Zi-Qiang Zhu ,  Xiao-Cheng Zhu ,  Shu-Ying Sheu

Inventor： Zi-Qiang Zhu ,  Xiao-Cheng Zhu ,  Shu-Ying Sheu

IPC: H01R13/73

CPC classification number: H01R12/7064

Abstract: An electrical connector having a retention mechanism for steadily securing the electrical connector to a mating circuit board comprises a dielectric housing, a number of contacts received in the housing and shield for enclosing the housing. The retention mechanism comprises a pair of lugs integrally and downwardly extending from the shield. Each lug includes an engaging means forming a pair of barbs thereon and a cutout defined between the pair of barbs for engaging within a corresponding positioning hole defined in the mating circuit board. Each lug has a length substantially equal to a thickness of the mating circuit board so that the retention mechanism will not scrape away solder coated on an inner surface of each positioning hole of the circuit board. Thus, excellent soldering connections between the electrical connector and the mating circuit board are established.

Abstract translation: 具有用于将电连接器稳定地固定到配合电路板的保持机构的电连接器包括介电壳体，容纳在壳体中的多个触点和用于封闭壳体的屏蔽件。 保持机构包括从屏蔽件一体地向下延伸的一对凸耳。 每个凸耳包括在其上形成一对倒钩的接合装置和限定在所述一对倒钩之间的切口，用于接合在配合电路板中限定的对应的定位孔内。 每个凸耳的长度基本上等于配合电路板的厚度，使得保持机构不会刮掉涂覆在电路板的每个定位孔的内表面上的焊料。 因此，建立了电连接器和配合电路板之间的优良焊接连接。

公开(公告)号：US20170081287A1

公开(公告)日：2017-03-23

申请号：US15310488

申请日：2015-05-19

Applicant: Tesfaye BIFTU ,  Purakkattle BIJU ,  Timothy A. BLIZZARD ,  Zhengxia CHEN ,  Matthew J. CLEMENTS ,  Mingxiang CUI ,  Jessica L. FRIE ,  William K. HAGMANN ,  Bin HU ,  Hubert JOSIEN ,  Anilkumar G. NAIR ,  Christopher W. PLUMMER ,  Cheng ZHU ,  Merck Sharp & Dohme Corp.

Inventor： Tesfaye Biftu ,  Purakkattle Biju ,  Timothy A. Blizzard ,  Zhengxia Chen ,  Matthew J. Clements ,  Mingxiang Cui ,  Jessica L. Frie ,  William K. Hagmann ,  Bin Hu ,  Hubert Josien ,  Anilkumar G. Nair ,  Christopher W. Plummer ,  Cheng Zhu

IPC: C07D221/16 ,  A61K31/438 ,  C07D405/12 ,  C07D401/12 ,  A61K31/444 ,  C07C61/39 ,  A61K31/192 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/538 ,  C07D413/12 ,  A61K31/55 ,  C07D215/14 ,  A61K31/47 ,  C07D401/04 ,  A61K45/06

CPC classification number: C07D221/16 ,  A61K31/192 ,  A61K31/366 ,  A61K31/397 ,  A61K31/435 ,  A61K31/438 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/538 ,  A61K31/55 ,  A61K45/06 ,  C07C61/39 ,  C07C2602/08 ,  C07C2603/12 ,  C07D215/14 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  A61K2300/00

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.