公开(公告)号：US20140230327A1

公开(公告)日：2014-08-21

申请号：US14232127

申请日：2012-07-09

申请人： Scott Edmondson ,  Bruce Toase

发明人： Scott Edmondson ,  Bruce Toase

IPC分类号： B05B1/00

CPC分类号： B05B1/005 ,  C10J3/02 ,  C10J3/74 ,  C10J2200/09 ,  C10J2300/0956 ,  C10J2300/0959 ,  F23L1/00 ,  F27D1/147

摘要： A gasification inlet (2) comprising: an annular manifold having a frame (4) supporting a radially inner wall formed by a first annulus of fire bricks (6) and supporting an upper wall formed by a second annulus of fire bricks (8), the upper wall and/or the inner wall being provided with fluid flow openings (16a, 16b).

摘要翻译： 一种气化入口（2），包括：环形歧管，其具有支撑由第一防火砖环（6）形成的径向内壁的框架（4），并且支撑由第二火圈（8）形成的上壁， 上壁和/或内壁设有流体流动开口（16a，16b）。

公开(公告)号：US07858629B2

公开(公告)日：2010-12-28

申请号：US12226048

申请日：2007-04-10

申请人： Richard Berger ,  Scott Edmondson ,  Alexa Hansen ,  Cheng Zhu

发明人： Richard Berger ,  Scott Edmondson ,  Alexa Hansen ,  Cheng Zhu

IPC分类号： A61K31/496 ,  A61K31/4709 ,  A61K31/454 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D401/12 ,  C07D233/90 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14

摘要： Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

公开(公告)号：US20080021009A1

公开(公告)日：2008-01-24

申请号：US11587605

申请日：2005-04-29

申请人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott Edmondson

发明人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott Edmondson

IPC分类号： A61K31/4245 ,  A61K31/397 ,  A61K31/4525 ,  A61K31/454 ,  A61P3/10 ,  C07D271/07 ,  C07D413/08

CPC分类号： C07D271/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新的1,2,4-恶二唑衍生物，其可用于治疗或预防其中二肽基肽酶 - 涉及IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20080009510A1

公开(公告)日：2008-01-10

申请号：US11667415

申请日：2005-11-22

申请人： Scott Edmondson ,  Anthony Mastracchio ,  Jason Cox

发明人： Scott Edmondson ,  Anthony Mastracchio ,  Jason Cox

IPC分类号： A61K31/44 ,  A61P3/00 ,  C07D471/00

CPC分类号： C07D471/04 ,  C07D471/14

摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20060270679A1

公开(公告)日：2006-11-30

申请号：US11500252

申请日：2006-08-07

申请人： Scott Edmondson ,  Michael Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma Parmee ,  Ann Weber ,  Jinyou Xu

发明人： Scott Edmondson ,  Michael Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma Parmee ,  Ann Weber ,  Jinyou Xu

IPC分类号： A61K31/498 ,  C07D487/04

CPC分类号： A61K31/4985 ,  A61K31/498 ,  A61K38/28 ,  A61K45/06 ,  C07D487/04 ,  Y10S514/866 ,  A61K2300/00

摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

公开(公告)号：US20100113492A1

公开(公告)日：2010-05-06

申请号：US12521648

申请日：2008-01-22

申请人： Scott Edmondson ,  David E. Kaelin ,  Randy Sweis

发明人： Scott Edmondson ,  David E. Kaelin ,  Randy Sweis

IPC分类号： A61K31/506 ,  C07D403/12 ,  C07D401/12 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/505 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： Certain novel substituted aminopyrimidines are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

摘要翻译： 某些新型取代的氨基嘧啶是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

公开(公告)号：US20090281117A1

公开(公告)日：2009-11-12

申请号：US12226115

申请日：2007-04-10

申请人： Joseph L. Duffy ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

发明人： Joseph L. Duffy ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

IPC分类号： A61K31/497 ,  C07D403/06 ,  C07D405/14

CPC分类号： C07D233/90 ,  C07D403/04 ,  C07D405/04

摘要： Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

摘要翻译： 某些新型取代的咪唑4-甲酰胺是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

公开(公告)号：US20090118300A1

公开(公告)日：2009-05-07

申请号：US12225906

申请日：2007-04-10

申请人： Richard Berger ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

发明人： Richard Berger ,  Scott Edmondson ,  Hansen Alexa ,  Cheng Zhu

IPC分类号： A61K31/496 ,  C07D403/06 ,  A61P3/04 ,  A61K31/454 ,  C07D401/06

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D405/14

摘要： Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

摘要翻译： 某些新型取代的咪唑4-甲酰胺是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

公开(公告)号：US20070021477A1

公开(公告)日：2007-01-25

申请号：US10560771

申请日：2004-06-10

申请人： Scott Edmondson ,  Anthony Mastracchio ,  Emma Parmee

发明人： Scott Edmondson ,  Anthony Mastracchio ,  Emma Parmee

IPC分类号： A61K31/428 ,  C07D417/02

CPC分类号： C07D417/06 ,  C07D403/06 ,  C07D413/06

摘要： The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的新型环己基甘氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20140057893A1

公开(公告)日：2014-02-27

申请号：US14110332

申请日：2012-04-05

申请人： Scott Edmondson ,  Zhiqiang Guo ,  Harold B. Wood ,  Andrew W. Stamford ,  Michael W. Miller ,  Duane E. DeMong ,  Gregori J. Morriello ,  Rajan Anand ,  Vincent J. Colandrea ,  Megan Macala ,  Milana Maletic ,  Cheng Zhu ,  Yuping Zhu ,  Wanying Sun ,  Kake Zhao ,  Yong Huang ,  Joel M. Harris ,  Lehua Chang ,  Nam Fung Kar ,  Zhiyong Hu ,  Liping Wang ,  Bowei Wang ,  Ping Liu ,  Jason W. Szewczyk ,  William B. Geiss

发明人： Scott Edmondson ,  Zhiqiang Guo ,  Harold B. Wood ,  Andrew W. Stamford ,  Michael W. Miller ,  Duane E. DeMong ,  Gregori J. Morriello ,  Rajan Anand ,  Vincent J. Colandrea ,  Megan Macala ,  Milana Maletic ,  Cheng Zhu ,  Yuping Zhu ,  Wanying Sun ,  Kake Zhao ,  Yong Huang ,  Joel M. Harris ,  Lehua Chang ,  Nam Fung Kar ,  Zhiyong Hu ,  Liping Wang ,  Bowei Wang ,  Ping Liu ,  Jason W. Szewczyk ,  William B. Geiss

IPC分类号： C07D513/04 ,  C07D413/14 ,  C07D413/04 ,  C07D498/04 ,  C07D405/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/12 ,  C07D211/22

CPC分类号： C07D513/04 ,  A61K9/4858 ,  C07D211/22 ,  C07D401/12 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法