公开(公告)号：US20070248611A1

公开(公告)日：2007-10-25

申请号：US11670096

申请日：2007-02-01

Applicant: Chia-Yang Lin ,  Arnon Rosenthal ,  Jennifer Stratton

Inventor： Chia-Yang Lin ,  Arnon Rosenthal ,  Jennifer Stratton

IPC: A61K38/00 ,  A61K39/395 ,  A61P3/04

CPC classification number: A61K38/185 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/75

Abstract: This invention relates to methods for treating unwanted body weight loss (such as with cachexia and with aging), eating disorders (such as anorexia nervosa), or opioid-induced emesis by peripheral administration of a trkB agonist. The invention also relates to compositions and kits comprising a trkB agonist.

Abstract translation: 本发明涉及治疗不希望的体重减轻的方法（例如恶病质和老化），进食障碍（如神经性厌食症）或通过外周施用trkB激动剂的阿片样物质诱导的呕吐。 本发明还涉及包含trkB激动剂的组合物和试剂盒。

公开(公告)号：US20180282415A1

公开(公告)日：2018-10-04

申请号：US15765149

申请日：2016-09-27

Applicant: Chia-Yang LIN ,  Wei Wei Wu PRIOR ,  Yan QU ,  Changyu WANG ,  Merck Patent GmbH ,  Pfizer Inc.

Inventor： Chia-Yang LIN ,  Wei Wei Wu PRIOR ,  Yan QU ,  Changyu WANG

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/439 ,  A61K31/4545 ,  A61P35/00

Abstract: The present disclosure describes combination therapies useful for the treatment of cancer. In particular, the invention relates to a combination therapy which comprises a PD-1 axis binding antagonist and an ALK inhibitor for treating cancer.

公开(公告)号：US08298535B2

公开(公告)日：2012-10-30

申请号：US13033491

申请日：2011-02-23

Applicant: Chia-Yang Lin ,  Li-Fen Lee ,  Wenwu Zhai

Inventor： Chia-Yang Lin ,  Li-Fen Lee ,  Wenwu Zhai

IPC: A61K39/395 ,  C07K16/28 ,  C12N5/12

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

Abstract translation: 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。

公开(公告)号：US20110206698A1

公开(公告)日：2011-08-25

申请号：US13033491

申请日：2011-02-23

Applicant: Chia-Yang Lin ,  Li-Fen Lee ,  Wenwu Zhai

Inventor： Chia-Yang Lin ,  Li-Fen Lee ,  Wenwu Zhai

IPC: A61K39/395 ,  C07K16/28 ,  C12N5/10 ,  C07H21/04 ,  A61P3/10 ,  A61P37/06

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

Abstract translation: 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。

公开(公告)号：US20090291897A1

公开(公告)日：2009-11-26

申请号：US12508379

申请日：2009-07-23

Applicant: Chia-Yang Lin ,  Arnon Rosenthal ,  Jennifer Renee Stratton

Inventor： Chia-Yang Lin ,  Arnon Rosenthal ,  Jennifer Renee Stratton

IPC: A61K38/18 ,  A61P3/04

CPC classification number: A61K38/185 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/75

Abstract: This invention relates to methods for treating unwanted body weight loss (such as cachexia), eating disorders (such as anorexia nervosa), or opioid-induced emesis by peripheral administration of a trkB agonist. The invention also relates to compositions and kits comprising a trkB agonist.

Abstract translation: 本发明涉及通过外周施用trkB激动剂治疗不需要的体重减轻（如恶病质），进食障碍（如神经性厌食症）或阿片样物质诱导的呕吐的方法。 本发明还涉及包含trkB激动剂的组合物和试剂盒。