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公开(公告)号：US20160355574A1
公开(公告)日：2016-12-08
申请号：US14933517
申请日：2015-11-05
申请人： Arnon Rosenthal , Michael Leviten
发明人： Arnon Rosenthal , Michael Leviten
CPC分类号： C07K16/18 , A61K49/0002 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/564 , G01N33/6893 , G01N33/6896 , G01N2333/4716
摘要： The present disclosure is directed to humanized anti-C1q antibodies and methods of using them.
摘要翻译： 本公开涉及人源化抗C1q抗体及其使用方法。
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公开(公告)号：US20150050286A1
公开(公告)日：2015-02-19
申请号：US13302264
申请日：2011-11-22
申请人： JAUME PONS , ARNON ROSENTHAL
发明人： JAUME PONS , ARNON ROSENTHAL
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）以及编码其的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US08591898B2
公开(公告)日：2013-11-26
申请号：US12747262
申请日：2008-12-17
申请人： Ian William Mills , Stephen Charles Phillips , Arnon Rosenthal , David Peter Scholfield , David Louis Shelton
发明人： Ian William Mills , Stephen Charles Phillips , Arnon Rosenthal , David Peter Scholfield , David Louis Shelton
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/73
摘要： The present invention relates to the use of an anti-NGF antibody in the treatment or prevention of pain and/or a lower urinary tract symptom (LUTS) associated with interstitial cystitis and/or painful bladder syndrome and/or bladder pain syndrome.
摘要翻译： 本发明涉及抗NGF抗体在治疗或预防与间质性膀胱炎和/或疼痛膀胱综合征和/或膀胱疼痛综合征相关的疼痛和/或下尿路症状（LUTS）中的用途。
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4.发明授权Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same 有权通过施用神经生长因子拮抗剂和含有它们的组合物治疗骨关节炎疼痛的方法公开(公告)号：US08540990B2
公开(公告)日：2013-09-24
申请号：US11911305
申请日：2006-04-11
IPC分类号： A61K39/395 , A61P25/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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5.发明授权Antagonist antibodies directed against calcitonin gene-related peptide and methods using same 有权针对降钙素基因相关肽的拮抗剂抗体及使用其的方法公开(公告)号：US08007794B2
公开(公告)日：2011-08-30
申请号：US12093638
申请日：2006-11-02
申请人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
发明人： Joerg Zeller , Kristian T. Poulsen , Yasmina Noubia Abdiche , Jaume Pons , Sierra Leigh Jones Collier , Arnon Rosenthal
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K31/4045 , A61K39/3955 , A61K2039/505 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
摘要翻译： 本发明的特征在于通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关疾病如血管舒缩症状，包括头痛（例如偏头痛，丛集性头痛和紧张性头痛）和热潮红的方法。 还描述了拮抗剂抗体G1和衍生自指向CGRP的G1的抗体。
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6.发明申请Methods for Treating Osteoarthritis Pain By Administering a Nerve Growth Factor Antagonist and Compositions Containing the Same 有权通过管理神经生长因子拮抗剂及其组合物治疗骨关节炎疼痛的方法公开(公告)号：US20110033447A1
公开(公告)日：2011-02-10
申请号：US11911305
申请日：2006-05-23
IPC分类号： A61K39/395 , A61P25/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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7.发明授权公开(公告)号：US07807165B2
公开(公告)日：2010-10-05
申请号：US11195207
申请日：2005-08-01
申请人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
发明人： Arnon Rosenthal , Jaume Pons , Wei-Hsien Ho , Jan Markus Grimm
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
摘要翻译： 单克隆抗体9TL和衍生自针对淀粉样蛋白-β肽的9TL的抗体及其用于诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。 使用针对具有受损效应物功能的淀粉样蛋白-β肽的抗体治疗阿尔茨海默病和A＆Bgr的方法; 还描述了肽相关疾病。
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公开(公告)号：US07655232B2
公开(公告)日：2010-02-02
申请号：US11653206
申请日：2007-01-12
申请人： Jaume Pons , Arnon Rosenthal
发明人： Jaume Pons , Arnon Rosenthal
IPC分类号： A61K39/395 , C07K16/22 , C12P21/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
摘要翻译： 本发明涉及抗NGF抗体（例如抗NGF拮抗剂抗体）和编码该抗体的多核苷酸。 本发明还涉及在治疗和/或预防疼痛（包括手术后疼痛，类风湿性关节炎疼痛和骨关节炎疼痛）中使用此类抗体和/或多核苷酸。
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公开(公告)号：US07312319B2
公开(公告)日：2007-12-25
申请号：US10371003
申请日：2003-02-21
申请人： Arnon Rosenthal
发明人： Arnon Rosenthal
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475
摘要： A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4β, NT-4γ, and NT-4Δ. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
摘要翻译： 已经通过人类基因组DNA的PCR扩增鉴定了一种称为神经营养因子-4（NT-4）的新型多肽。 本文提供了可用于诊断和NT-4重组制备中的NT-4的核酸。 本文还提供了编码NT-4，称为NT-4beta，NT-4gamma和NT-4Delta的天然存在的氨基酸序列变体的核酸。 本发明的神经营养因子可用于神经细胞的治疗和诊断测定。
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公开(公告)号：US07259245B2
公开(公告)日：2007-08-21
申请号：US10174653
申请日：2002-06-17
CPC分类号： C12N9/1205 , C07K14/705 , C07K16/40 , C07K2319/00 , C12N2799/026 , G01N2500/04
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused.
摘要翻译： 本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，表达免疫粘附素，激动剂和对人和脊椎动物融合的拮抗剂（包括抗体）。
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