公开(公告)号：US20120283169A1

公开(公告)日：2012-11-08

申请号：US13287216

申请日：2011-11-02

Applicant: Rolf GREMPLER ,  Odd-Eric JOHANSEN ,  Thomas KLEIN ,  Gerd LUIPPOLD ,  Michael MARK

Inventor： Rolf GREMPLER ,  Odd-Eric JOHANSEN ,  Thomas KLEIN ,  Gerd LUIPPOLD ,  Michael MARK

IPC: A61K38/28 ,  A61P3/08 ,  A61P3/04 ,  A61P11/00 ,  A61P1/18 ,  A61P27/12 ,  A61P7/02 ,  A61P13/12 ,  A61P9/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/08 ,  A61P25/00 ,  A61P37/06 ,  A61P3/12 ,  A61P3/10

CPC classification number: A61K38/28 ,  A61K31/341 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions

Abstract translation: 本发明涉及根据权利要求1的药物组合物，其包含适合于治疗或预防选自1型糖尿病，2型糖尿病，葡萄糖耐量异常和高血糖症的一种或多种病症的SGLT2抑制剂和胰岛素。 此外，本发明涉及用于预防或治疗代谢紊乱及相关病症的方法

公开(公告)号：US5691185A

公开(公告)日：1997-11-25

申请号：US242098

申请日：1994-05-13

Applicant: Fran.cedilla.oise Dickely ,  Eric Johansen ,  Dan Nilsson ,  Egon Bech Hansen ,  Per Str.o slashed.man

Inventor： Fran.cedilla.oise Dickely ,  Eric Johansen ,  Dan Nilsson ,  Egon Bech Hansen ,  Per Str.o slashed.man

IPC: C12N1/21 ,  C12N15/68 ,  C12N15/74 ,  C12N1/20 ,  C12N15/00

CPC classification number: C12N15/68 ,  C12N15/746

Abstract: Useful mutants of lactic acid bacteria or plasmids capable of replicating in lactic acid bacteria, comprising nonsense mutation suppressor-encoding genes, the use of such suppressor genes for confining a replicon to a specific lactic acid bacterium or to a lactic acid bacterium growing in a particular environment and for controlling the number of lactic acid bacterial cells in a particular environment.

Abstract translation: 乳酸菌或能在乳酸菌中复制的质粒的有用突变体，包括无义突变抑制基因编码基因，将这种抑制基因用于限制特定乳酸菌的复制子或特定生长的乳酸菌 环境和用于控制特定环境中的乳酸菌细胞的数量。