Abstract:
The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods.
Abstract:
A decision engine includes: a genetic algorithm framework including a knowledge base of standard configurations, a candidate selector generator and a selector to select a candidate configuration from a plurality of preferred standard configurations in response to the candidate selector generator; a parallelized reasoning framework including an attack surface reasoning algorithm module to compute the security and cost tradeoffs of an attack surface associated with each candidate configuration; and a user interface framework including a web service engine where users can interact and provide feedback on direction of an evolution used in a genetic algorithm search for evolving defenses.
Abstract:
Method for detecting switch degradation and failures having steps of collecting and labelling, into predefined categories, switch machine data relative to a predetermined controlled switch placed in supervised environment and conditions; storing the labeled data of each movement switch in a database and pre-processing the labelled data. A learning LSTM weights and cell parameters by performing a training phase on a LSTM network using the pre-processed data, thus obtaining a final LSTM model inclusive of architecture and parameters of the LSTM network suitable for analyzing switch data relative to movements of switches actually located on a railway track; collecting data relative to the movements of a switch located on a railway track; and classifying the switch movements into said categories by applying the collected data to the final LSTM, thus detecting switch degradations and failures.
Abstract:
A modified optical PAM communication system using multiple laser sources to generate each amplitude level. The systems can be applied separately or in conjunction with another modulation system such as SDM, MDM, WDM, TDM, or other communication systems. In an embodiment, a PAM-4 system will increase data rate by a factor of two, but more complicated schemes using more lasers can be utilized to generate higher efficiency schemes. For example, a 25 Gbps NRZ signal will give 50 Gbps PAM-4 signal and higher laser systems can generate PAM-8 or PAM-16 for 75 and 100 Gbps systems respectively. These can be further applied to SDM systems to generate higher data rates equivalent to the number of SDM channels multiplied by the PAM efficiency. In embodiments, the invention may combing PAM with WDM and SDM to achieve multiple bits per symbol.
Abstract:
An optical-to-optical inline spatial domain multiplexing (SDM) de-multiplexer for SDM communication comprising a plurality of concentric core layers each having a beveled output end and a cladding layer concentrically surrounding each core layer. The cladding layer has an index that is lower than the index of the core layer it surrounds. Also included is a system for SDM communication comprising at least one optical source to transmit optical energy, an SDM optical carrier fiber to receive optical energy from the source and output a plurality of SDM signals, a SDM de-multiplexer as described above wherein the SDM signals output from the carrier fiber are each incident upon one of the core layers, optical output fibers positioned to couple SDM signals from each cladding layer, and a photodetector communicatively coupled to the outputs of the optical output fibers to couple the SDM signals output from the optical output fibers.
Abstract:
A reconfigurable motion generator and control system for multi-phase motion generation. Reconfigurable motion generators are a new class of mechanical devices that are designed for a specific part family and their associated motion generation tasks. The reconfigurable motion generator may utilize revolute joints for link length and pivot adjustment to achieve different configurations from the same set of links. Due to the nature of adjustment of the mechanism this methodology may be used for different types of motion generation tasks such as (a) common start position, (b) common end position, (c) common intermediate position, and (d) distinct motion generation tasks with no common positions. This technique can be applied towards the synthesis of reconfigurable motion generators for use in many planar or spherical applications involving multi-phase function, path, and motion generation tasks.
Abstract:
A rotating grooming brush comprising a brush hub having grooming elements and shroud elements, and method for grooming a surface having an unwanted material thereon. The elements extend from the brush hub and may be positioned near its outer periphery. The elements may be grooming elements forming an array and shroud elements forming a shroud array. A rigid or elastomeric shroud extending from the brush hub surface may optionally be included about the edge of the brush hub, to the outside of the grooming elements. Rotation of the grooming attachment brush causes a low pressure region to build in the central area of the brush. This low pressure region creates a resulting force that forcefully attracts the grooming attachment brush to the surface to be groomed. The resulting force is controlled by the diameter of the brush hub, arrangement, of the elements and the speed of rotation.
Abstract:
A modified optical PAM communication system using multiple laser sources to generate each amplitude level. The systems can be applied separately or in conjunction with another modulation system such as SDM, MDM, WDM, TDM, or other communication systems. In an embodiment, a PAM-4 system will increase data rate by a factor of two, but more complicated schemes using more lasers can be utilized to generate higher efficiency schemes. For example, a 25 Gbps NRZ signal will give 50 Gbps PAM-4 signal and higher laser systems can generate PAM-8 or PAM-16 for 75 and 100 Gbps systems respectively. These can be further applied to SDM systems to generate higher data rates equivalent to the number of SDM channels multiplied by the PAM efficiency. In embodiments, the invention may combing PAM with WDM and SDM to achieve multiple bits per symbol.
Abstract:
A multiplexed optical communication system comprising a carrier optical fiber, a plurality of launching light sources, and a matching plurality of multiplexer/demultiplexers and photodetectors is described and claimed. Optical communication channel separation by Spatial Domain Multiplexing (SDM), Optical Angular Momentum (OAM) multiplexing, and Wavelength Division Multiplexing (WDM) is used in combination to achieve significant increase in optical communication channel bandwidth over the prior art. The launching light sources may be positioned such that the light beams are incident on the receiving end of the carrier optical fiber at desired angles including complementary angles. Crosstalk between optical communication channels is minimal. The communication bandwidth of a TDM system may be increased by an order of magnitude due the layered WDM/SDM/OAM data multiplexing of the invention.
Abstract:
A vertically rotating grooming attachment brush comprising a brush hub and bristles, and method for cleaning a surface having organic biofouling. The bristles extend from the brush hub and are positioned at or near its outer rim. One or more rows of bristles can be included. The bristles can be grooming bristles or shroud bristles or a combination of the two. A rigid or elastomeric shroud or skirt can also be included about the edge of the brush hub. Vertical rotation of the grooming attachment brush causes a low pressure region to build in the central area of the brush hub. This low pressure region creates a force that forcefully attracts the grooming attachment brush to the surface to be cleaned.