公开(公告)号：US4552878A

公开(公告)日：1985-11-12

申请号：US534173

申请日：1983-09-19

Applicant: Gerard Ferrand ,  Herve Dumas ,  Michel Bayssat ,  Jean-Claude Depin

Inventor： Gerard Ferrand ,  Herve Dumas ,  Michel Bayssat ,  Jean-Claude Depin

IPC: A61K31/53 ,  A61P25/24 ,  A61P25/26 ,  C07D253/08 ,  C07D495/04 ,  C07D403/06

CPC classification number: C07D253/08 ,  C07D495/04

Abstract: This invention relates to benzo- and thieno-triazine-1,2,3 ones-4 represented by the formula ##STR1## in which m is 2, 3 or 4, X is the vinylene group --CH.dbd.CH-- or a sulfur atom; R.sub.1 and R.sub.2 can be alike or different and are hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or trifluoromethyl radical; when X is --CH--CH-- n is 0, 1 or 2 and R is hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or nitro group; when X is a sulfur atom, R is hydrogen or constitutes a --CH.sub.2 --.sub.4 chain between the two open positions of the thiophenic ring. The compounds are useful as antidepressant drugs.

Abstract translation: 本发明涉及由式“IMAGE”表示的苯并 - 噻吩并三嗪-1,2,3,4-四烷基，其中m为2,3或4，X为亚乙烯基-CH = CH-或硫原子 ; R 1和R 2可以相同或不同，为氢，卤素，低级烷基，低级烷氧基或三氟甲基; 当X是-CH-CH- n是0,1或2且R是氢时，卤素，低级烷基，低级烷氧基或硝基; 当X是硫原子时，R是氢或在噻吩环的两个开放位置之间构成-CH2-4链。 该化合物可用作抗抑郁药物。

公开(公告)号：US5270465A

公开(公告)日：1993-12-14

申请号：US970839

申请日：1992-11-03

Applicant: Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Yvette Quentin

Inventor： Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Yvette Quentin

IPC: C07D475/02 ,  A61K31/505

CPC classification number: C07D475/02

Abstract: The present invention relates to 4(3H)-pteridinones represented by the formula: ##STR1## in which X is an oxygen atom or a sulphur atom, Y is a hydrogen atom, a lower alkyl radical, especially a methyl radical, at the 6-position or a hydroxyl group at the 7-position, R.sub.1 is a hydrogen atom, a lower alkyl radical, a substituted or unsubstituted phenyl radical, a benzyl radical, a methoxymethyl group, an acetyl group, a 2-acetoxyethyl group or a 2,2,2-trifluoroethyl group and R.sub.2 is a hydrogen atom or a lower alkyl radical, especially a methyl radical.Application of these compounds as anti-allergic drugs.

Abstract translation: 本发明涉及由下式表示的4（3H） - 蝶啶酮：其中X是氧原子或硫原子，Y是氢原子，低级烷基，特别是甲基，在6 位置或羟基，R1是氢原子，低级烷基，取代或未取代的苯基，苄基，甲氧基甲基，乙酰基，2-乙酰氧基乙基或2 ，2,2-三氟乙基，R 2为氢原子或低级烷基，特别是甲基。 这些化合物作为抗过敏药物的应用。

公开(公告)号：US5001134A

公开(公告)日：1991-03-19

申请号：US461515

申请日：1990-01-05

Applicant: Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Gilles Chavernac

Inventor： Gerard Ferrand ,  Herve Dumas ,  Jean-Claude Depin ,  Gilles Chavernac

IPC: C07D211/14 ,  A61K9/00 ,  A61K31/00 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/454 ,  A61P9/00 ,  A61P9/12 ,  C07D211/32 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04

CPC classification number: C07D405/04 ,  C07D211/32 ,  C07D413/04

Abstract: The present invention relates to piperidines denoted by the formula: ##STR1## in which X is the 4-fluorobenzoyl, 2-(4-fluorophenyl)-1,3-dioxolan-2-yl or 6-fluoro-1,2-benzisoxazol-3-yl group, Y is a hydrogen atom or the hydroxyl group, m is an integer between 0 and 4 inclusive, n is 0 or 1, Q is a nitrogen atom or the methine group; when Q is a nitrogen atom, R is the cyano group or the carbamoyl group; when Q is the methine group, R is the nitro group; R.sup.1 and R.sup.2 may be identical or different and are hydrogen, a lower alkyl radical, the phenyl radical, the 2,2,2-trifluoroethyl group or the 2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl group; or the NR.sup.1 R.sup.2 structural unit is the piperidino radical or the 4-(4-fluorobenzoyl)-1-piperidinyl group.Application of these compounds as antihypertensive medications.

Abstract translation: 本发明涉及由下式表示的哌啶：其中X是4-氟苯甲酰基，2-（4-氟苯基）-1,3-二氧戊环-2-基或6-氟-1,2-苯并异恶唑 3-基，Y为氢原子或羟基，m为0〜4的整数，n为0或1，Q为氮原子或次甲基。 当Q为氮原子时，R为氰基或氨基甲酰基; 当Q为次甲基时，R为硝基; R 1和R 2可以相同或不同，为氢，低级烷基，苯基，2,2,2-三氟乙基或2- [4-（4-氟苯甲酰基）-1-哌啶基]乙基; 或NR1R2结构单元是哌啶子基或4-（4-氟苯甲酰基）-1-哌啶基。 这些化合物作为抗高血压药物的应用。

公开(公告)号：US4649153A

公开(公告)日：1987-03-10

申请号：US746785

申请日：1985-06-20

Applicant: Gerard Ferrand ,  Jacques Barbanton ,  Jean-Claude Depin

Inventor： Gerard Ferrand ,  Jacques Barbanton ,  Jean-Claude Depin

IPC: A61K31/38 ,  A61K31/381 ,  A61P25/04 ,  A61P29/00 ,  C07D333/00 ,  C07D333/24 ,  C07D333/78 ,  C07D409/04 ,  C07D409/06 ,  C07D333/56

CPC classification number: C07D409/04 ,  C07D333/24 ,  C07D333/78 ,  C07D409/06

Abstract: 5,6-dihydro-4H-cyclopenta[b]thiophene-6-carboxylic acids represented by the formula: ##STR1## in which Ar is a phenyl or thienyl group, optionally substituted, or a furyl group; R is a lower alkyl radical, are useful as anti-inflammatory and analgesic medicines.

Abstract translation: 由下式表示的5,6-二氢-4H-环戊二烯并[b]噻吩-6-羧酸：其中Ar是任选取代的苯基或噻吩基或呋喃基; R是低级烷基，可用作抗炎镇痛药。

公开(公告)号：US4163852A

公开(公告)日：1979-08-07

申请号：US860188

申请日：1977-12-13

Applicant: Gerard Ferrand ,  Jean-Pierre Maffrand

Inventor： Gerard Ferrand ,  Jean-Pierre Maffrand

IPC: C07D495/04

CPC classification number: C07D495/04 ,  Y10S514/822

Abstract: This invention relates to a process for the preparation of tetrahydro-thieno[3,2-c]pyridine derivatives of the formula ##STR1## AND THEIR ISOMERIC TETRAHYDRO-THIENO[2,3-C]PYRIDINE DERIVATIVES IN WHICH R.sub.1 represents hydrogen, a lower alkyl or alkoxy radical, an aryl radical or an aralkyl radical; R.sub.2 and R.sub.3 represent hydrogen, halogen, a lower alkyl or alkoxy group, a di(loweralkyl)amino, nitro, cyano or acetamido group or, together with the phenyl nucleus to which they are attached, form a polycyclic aromatic ring, comprising reacting a tetrahydrothieno[3,2-c]pyridine derivative of the formula: ##STR2## OR A DERIVATIVE OF ITS ISOMER, TETRAHYDRO[2,3-C]PYRIDINE, WITH FORMALDEHYDE H-CHO and a phenol of the formula: ##STR3##

Abstract translation: 本发明涉及制备式（Ia）的四氢噻吩并[3,2-c]吡啶衍生物及其异构四氢 - 噻吩并[2,3-C]吡啶衍生物的方法，其中R 1表示 氢，低级烷基或烷氧基，芳基或芳烷基; R 2和R 3表示氢，卤素，低级烷基或烷氧基，二（低级烷基）氨基，硝基，氰基或乙酰氨基，或与它们所连接的苯基一起形成多环芳环，包括使 （IIa）的四氢噻吩并[3,2-c]吡啶衍生物或其异构体衍生物，四氢呋喃并[2,3-C]吡啶与甲醛H-CHO和下式的苯酚： （III）。