公开(公告)号：US20120040452A1

公开(公告)日：2012-02-16

申请号：US13242019

申请日：2011-09-23

申请人： Yasuharu NISHIMURA ,  Tetsuya NAKATSURA ,  Hiroyuki KOMORI

发明人： Yasuharu NISHIMURA ,  Tetsuya NAKATSURA ,  Hiroyuki KOMORI

IPC分类号： C12N5/00 ,  C07K16/00 ,  C12N15/11

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4725

摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.

摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。

公开(公告)号：US20090239806A1

公开(公告)日：2009-09-24

申请号：US12063165

申请日：2006-08-08

申请人： Yasuharu Nishimura ,  Tetsuya Nakatsura ,  Hiroyuki Komori

发明人： Yasuharu Nishimura ,  Tetsuya Nakatsura ,  Hiroyuki Komori

IPC分类号： A61K38/08 ,  C07K7/06 ,  C12N5/08 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4725

摘要： It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B): (A) a peptide, which has the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.

摘要翻译： 本发明的目的是鉴定可与HLA-A2结合并激活人类杀伤T细胞的磷脂酰肌醇蛋白聚糖-3衍生肽，以提供进行免疫治疗的手段，该免疫治疗能够靶向约40％ 患有几种类型癌症的日本患者，其高水平表达GPC3。 本发明提供下述（A）或（B）中任一项所述的肽：（A）具有SEQ ID NO：1〜3中任一项所示的氨基酸序列的肽; 或（B）肽，其具有相对于SEQ ID NO：1至3中任一项所示的氨基酸序列取代或添加一个或两个氨基酸的氨基酸序列，并且其具有 诱导杀伤T细胞。

公开(公告)号：US20090282091A1

公开(公告)日：2009-11-12

申请号：US12424047

申请日：2009-04-15

申请人： Hiroyuki KOMORI

发明人： Hiroyuki KOMORI

IPC分类号： G06F12/00 ,  G06F17/30 ,  G06F12/02

CPC分类号： G06F17/30218 ,  G06F12/0246 ,  G06F2212/7205 ,  G06F2212/7207

摘要： A file system includes: a data controller that inverts logic of input data to convert the input data into accumulation data; a nonvolatile storage that has storage areas in which the accumulation data is stored and a table section to which use states of the storage areas are written; and a controller that controls the nonvolatile storage so as to store the accumulation data in the storage areas in accordance with the use states written to the table section.

摘要翻译： 文件系统包括：数据控制器，其将输入数据的逻辑转换成将输入数据转换为累积数据; 具有存储积存数据的存储区域和写入存储区域的使用状态的表部分的非易失性存储器; 以及控制器，其控制所述非易失性存储器，以便根据写入所述表部分的使用状态将所述累积数据存储在所述存储区域中。

公开(公告)号：US20080267583A1

公开(公告)日：2008-10-30

申请号：US12050842

申请日：2008-03-18

申请人： Hiroyuki Komori ,  Takehiko Numata

发明人： Hiroyuki Komori ,  Takehiko Numata

IPC分类号： H04N5/91

CPC分类号： H04N5/76 ,  H04N5/782 ,  H04N21/47214

摘要： According to one embodiment, a video-recording programming apparatus includes control circuit, reception circuit, which is controlled by the control circuit, for selecting and receiving a predetermined program, and program presetting memory capable of storing preset-recording information of a periodically broadcast program. The control circuit includes video-recording determination circuit for determining whether preset-recording of the periodically broadcast program, which is stored in the program presetting memory, has been executed or not, count circuit for counting, in a case where the video-recording determination circuit determines that the preset-recording of the periodically broadcast program has not been executed, a number of times of non-execution of the preset-recording of the periodically broadcast program, and display control circuit for causing display to display the number of times which is counted by the count circuit, together with the preset-recording information.

摘要翻译： 根据一个实施例，视频记录编程设备包括控制电路，由控制电路控制的用于选择和接收预定程序的接收电路，以及能够存储周期性广播节目的预设记录信息的程序预置存储器 。 控制电路包括：视频记录确定电路，用于在视频记录确定的情况下确定是否已经执行了存储在程序预置存储器中的周期性广播节目的预设录制，计数电路 电路确定周期性广播节目的预设录像尚未被执行，不执行周期性广播节目的预设录制的次数，以及显示控制电路，使得显示器显示次数， 由计数电路与预设记录信息一起计数。

公开(公告)号：US20080208878A1

公开(公告)日：2008-08-28

申请号：US12071715

申请日：2008-02-25

申请人： Hiroyuki Komori ,  Toshimasa Suzuki

发明人： Hiroyuki Komori ,  Toshimasa Suzuki

IPC分类号： G06F17/30

CPC分类号： G06F16/13

摘要： Disclosed is a computer-readable recording medium recording a file processing program capable of achieving reduction of a processing time. A notifying section sequentially notifies, based on information acquisition instructions from an application, the application of a plurality of data blocks stored in a storing section. An identifier grasping section refers to identifiers of the respective data blocks stored in the storing section and grasps an identifier corresponding to a data block currently notified of by the notifying section. An executing section receives, when the notifying section notifies the application of the plurality of data blocks, data execution instructions from the application and reads out and executes a data block corresponding to an identifier most recently grasped by the identifier grasping section.

摘要翻译： 公开了记录能够实现处理时间缩短的文件处理程序的计算机可读记录介质。 通知单元根据来自应用的信息获取指示，依次通知存储在存储部中的多个数据块的应用。 标识符抓取部分是指存储在存储部分中的各个数据块的标识符，并且掌握对应于由通知部分通知的数据块的标识符。 当通知部分通知应用程序时，执行部分从应用程序接收数据执行指令，并读出并执行对应于由标识符抓取部分最近掌握的标识符的数据块。