公开(公告)号：US20120087561A1

公开(公告)日：2012-04-12

申请号：US13248309

申请日：2011-09-29

Applicant: Christoph Guetter ,  Jens Gühring ,  Marie-Pierre Jolly ,  Arne Littmann ,  Manuela Rick ,  Michaela Schmidt ,  Hui Xue

Inventor： Christoph Guetter ,  Jens Gühring ,  Marie-Pierre Jolly ,  Arne Littmann ,  Manuela Rick ,  Michaela Schmidt ,  Hui Xue

IPC: G06K9/46

CPC classification number: G06T7/0083 ,  G06T7/12 ,  G06T7/174 ,  G06T2207/10016 ,  G06T2207/10072 ,  G06T2207/10116 ,  G06T2207/20104 ,  G06T2207/30004

Abstract: A method for identifying a region of interest within a time sequence of images includes acquiring a time sequence of images comprising a plurality of image frames. Image segmentation is performed to segment a region of interest (ROI) from within each of the plurality of image frames of the time sequence of images. Manual edits are received for the ROI within one or more of the plurality of image frames. The manual edits are propagated to other image frames of the plurality of images. An extent to which each of the manual edits are propagated to other image frames is dependent upon a transformation function or deformation field used to propagate the manual edits and a weighing factor that is influenced by a distance in time between the other image frames and the frames that have been manually edited.

Abstract translation: 用于识别图像的时间序列内的感兴趣区域的方法包括获取包括多个图像帧的图像的时间序列。 执行图像分割以从图像的时间序列的多个图像帧的每一个内分割感兴趣区域（ROI）。 对于多个图像帧中的一个或多个中的ROI，接收手动编辑。 手动编辑被传播到多个图像的其他图像帧。 每个手动编辑传播到其他图像帧的程度取决于用于传播手动编辑的变换函数或变形字段以及受其他图像帧和帧之间的时间距离的影响的称重因子 已经被手动编辑。

公开(公告)号：US20120078085A1

公开(公告)日：2012-03-29

申请号：US13246910

申请日：2011-09-28

Applicant: Hui Xue ,  Marie-Pierre Jolly ,  Xiaoguang Lu ,  Jens Gühring

Inventor： Hui Xue ,  Marie-Pierre Jolly ,  Xiaoguang Lu ,  Jens Gühring

IPC: A61B5/055 ,  A61B5/02

CPC classification number: A61B5/055 ,  A61B5/0263 ,  G01R33/5601 ,  G01R33/56366 ,  G01R33/56509 ,  G01R33/5659

Abstract: A method (100) of processing myocardial MR perfusion images that corrects imaging errors arising from myocardial motion and B-1 field inhomogeneity (115-135); segments the myocardium images (140, 145); and calculates perfusion measures that enable analysis of the segmented myocardium images (150).

Abstract translation: 一种处理心肌MR灌注图像的方法（100），其校正由心肌运动和B-1场不均匀性引起的成像误差（115-135）; 分割心肌图像（140,145）; 并计算能够分析分段心肌图像的灌注测量（150）。

公开(公告)号：US20110208039A1

公开(公告)日：2011-08-25

申请号：US13031321

申请日：2011-02-21

Applicant: Jens Guehring ,  Hui Xue ,  Sven Zuehlsdorff

Inventor： Jens Guehring ,  Hui Xue ,  Sven Zuehlsdorff

IPC: A61B5/055

CPC classification number: G01R33/56366 ,  G01R33/246 ,  G01R33/5601 ,  G01R33/5659

Abstract: Method of correcting cardiac perfusion MR imaging for inhomogeneities (430) caused by non-uniform receiver coil fields using proton density weighted images (410) and B-Spline Free-Form Deformation (425).

Abstract translation: 使用质子密度加权图像（410）和B样条自由形式变形（425），校正由不均匀接收器线圈场引起的不均匀性（430）的心脏灌注MR成像的方法。

公开(公告)号：US09790500B2

公开(公告)日：2017-10-17

申请号：US15211857

申请日：2016-07-15

Applicant: Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

Inventor： Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7125

CPC classification number: C12N15/113 ,  A61K31/7125 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/321 ,  C12N2310/3525 ,  C12N2310/3527

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

公开(公告)号：US09279873B2

公开(公告)日：2016-03-08

申请号：US13534112

申请日：2012-06-27

Applicant: Hui Xue ,  Yu Ding

Inventor： Hui Xue ,  Yu Ding

IPC: G01V3/00 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/5611 ,  G01R33/56509

Abstract: Parallel imaging magnetic resonance reconstruction is performed with temporal sensitivity. Rather than estimate the coil sensitivity once for each coil of an array, the coil sensitivity at different times is estimated. The movement of the patient may result in different sensitivities at different times. By using the time varying sensitivity in iterative, self-consistent, non-linear parallel imaging, real-time imaging may be provided with stable artifacts in view of increasing SNR even with higher reduction factors (e.g., 4-6).

Abstract translation: 平行成像磁共振重建以时间灵敏度进行。 不是对阵列的每个线圈估计线圈灵敏度，而是估计不同时间的线圈灵敏度。 患者的运动可能导致不同时间的不同灵敏度。 通过在迭代，自相一致的非线性并行成像中使用时变灵敏度，考虑到即使具有较高的减少因子（例如，4-6）也增加了SNR，可以提供稳定的伪像。

公开(公告)号：US08649585B2

公开(公告)日：2014-02-11

申请号：US13295416

申请日：2011-11-14

Applicant: Hui Xue ,  Saurabh Shah ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff ,  Jens Guehring

Inventor： Hui Xue ,  Saurabh Shah ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff ,  Jens Guehring

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06T5/002 ,  G06T2207/10016 ,  G06T2207/10088 ,  G06T2207/20221 ,  G06T2207/30048

Abstract: A method and system for retrospective image combination for free-breathing magnetic resonance (MR) images is disclose. A free-breathing cardiac MR image acquisition including a plurality of frames is received. A key frame is selected of the plurality of frames. A deformation field for each frame to register each frame with the key frame. A weight is determined for each pixel in each frame based on the deformation field for each frame under a minimum total deformation constraint. A combination image is then generated as a weighted average of the frames using the weight determined for each pixel in each frame.

Abstract translation: 公开了用于自由呼吸磁共振（MR）图像的回顾性图像组合的方法和系统。 接收包括多个帧的自由呼吸心脏MR图像采集。 选择多个帧中的关键帧。 每个帧的变形场用关键帧来记录每个帧。 基于每个帧在最小总变形约束下的变形场，为每个帧中的每个像素确定权重。 然后，使用为每个帧中的每个像素确定的权重，生成组合图像作为帧的加权平均。

公开(公告)号：US20130278259A1

公开(公告)日：2013-10-24

申请号：US13866328

申请日：2013-04-19

Applicant: Andreas Greiser ,  Peter Schmitt ,  Hui Xue

Inventor： Andreas Greiser ,  Peter Schmitt ,  Hui Xue

IPC: G01R33/50

CPC classification number: G01R33/50 ,  G01R33/56 ,  G01R33/56509

Abstract: In a method for a rapid determination of spatially resolved magnetic resonance relaxation parameters in an area of examination, a preparation pulse is radiated into the area of examination. During the relaxation of the longitudinal magnetization, spatially encoded magnetic resonance signals are acquired at a minimum of two different points in time using a fast magnetic resonance sequence. At each inversion time, an image data record is reconstructed from the magnetic resonance signals, which are elastically registered to each other. From the recorded image data records, values of magnetic resonance relaxation parameters are spatially accurately determined.

Abstract translation: 在用于在检查区域中快速确定空间分辨的磁共振松弛参数的方法中，准备脉冲被辐射到检查区域中。 在松弛纵向磁化期间，使用快速磁共振序列在至少两个不同的时间点获取空间编码的磁共振信号。 在每个反转时间，从彼此弹性对准的磁共振信号重建图像数据记录。 从记录的图像数据记录中，磁共振松弛参数的值在空间上被精确地确定。

公开(公告)号：US20120235679A1

公开(公告)日：2012-09-20

申请号：US13413812

申请日：2012-03-07

Applicant: Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

Inventor： Hui Xue ,  Christoph Guetter ,  Yu Ding ,  Marie-Pierre Jolly ,  Orlando P. Simonetti ,  Jens Guehring ,  Sven Zuehlsdorff ,  Arne Littmann

IPC: G01R33/44

CPC classification number: G01R33/56509 ,  G01R33/5611 ,  G01R33/56325

Abstract: Magnetic resonance reconstruction includes motion compensation. Inverse-consistent non-rigid registration is used to determine motion between shots. The motion is incorporated into reconstruction. The incorporation compensates for the motion resulting from the period over which the MR data is acquired.

Abstract translation: 磁共振重建包括运动补偿。 反向一致的非刚性配准用于确定镜头之间的运动。 动议被纳入重建。 该并入补偿了获取MR数据的期间产生的运动。

公开(公告)号：US20120189183A1

公开(公告)日：2012-07-26

申请号：US13237198

申请日：2011-09-20

Applicant: Hui Xue ,  Saurabh Shah ,  Jens Gühring ,  Andreas Greiser ,  Christophe Chefd'hotel ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff

Inventor： Hui Xue ,  Saurabh Shah ,  Jens Gühring ,  Andreas Greiser ,  Christophe Chefd'hotel ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Sven Zuehlsdorff

IPC: G06K9/40 ,  G06K9/00

CPC classification number: G06T5/50 ,  G01R33/448 ,  G01R33/56509 ,  G06T7/30 ,  G06T2207/10088 ,  G06T2207/20201 ,  G06T2207/30048

Abstract: A method for performing motion compensation in a series of magnetic resonance (MR) images includes acquiring a set of MR image frames spanning different points along an MR recovery curve. A motion-free synthetic image is generated for each of the acquired MR image frames using prior knowledge pertaining to an MR recovery curve. Each of the acquired MR images is registered to its corresponding generated synthetic images. Motion within each of the acquired MR image is corrected based on its corresponding generated synthetic image that has been registered thereto.

Abstract translation: 用于在一系列磁共振（MR）图像中执行运动补偿的方法包括获取沿着MR恢复曲线横跨不同点的一组MR图像帧。 使用与MR恢复曲线相关的先前知识，为每个所获取的MR图像帧生成无运动合成图像。 所获取的MR图像中的每一个被注册到其对应的生成的合成图像。 基于其对应的生成的已经被注册的合成图像来校正所获取的MR图像的每一个内的运动。

公开(公告)号：US20120177269A1

公开(公告)日：2012-07-12

申请号：US13234694

申请日：2011-09-16

Applicant: Xiaoguang Lu ,  Jens Gühring ,  Hui Xue ,  Marie-Pierre Jolly ,  Christoph Guetter ,  Bogdan Georgescu ,  Sven Zuehlsdorff ,  Arne Littmann

Inventor： Xiaoguang Lu ,  Jens Gühring ,  Hui Xue ,  Marie-Pierre Jolly ,  Christoph Guetter ,  Bogdan Georgescu ,  Sven Zuehlsdorff ,  Arne Littmann

IPC: G06K9/00

CPC classification number: G06K9/4609 ,  G06K2209/051 ,  G06T7/11 ,  G06T7/143 ,  G06T7/194 ,  G06T2207/10088 ,  G06T2207/20164 ,  G06T2207/30048

Abstract: A method including receiving an image sequence, wherein the image sequence includes a plurality of two-dimensional (2D) image frames of an organ arranged in a time sequence; constructing a three-dimensional (3D) volume by stacking a plurality of the 2D image frames in time order; detecting a best bounding box for a target of interest in the 3D volume, wherein the best bounding box is specified by a plurality of parameters including spatial and temporal information contained in the 3D volume; and determining the target of interest from the best bounding box.

Abstract translation: 一种包括接收图像序列的方法，其中所述图像序列包括以时间顺序排列的器官的多个二维（2D）图像帧; 通过以时间顺序堆叠多个2D图像帧来构造三维（3D）体积; 检测所述3D体积中感兴趣的目标的最佳边界框，其中所述最佳边界框由包括在所述3D体积中的空间和时间信息的多个参数指定; 并从最佳边界框确定感兴趣的目标。