公开(公告)号：US20120190082A1

公开(公告)日：2012-07-26

申请号：US13278105

申请日：2011-10-20

Applicant: Jin Sook CHANG ,  Jae Hyun JO ,  Hyun Ae BAE ,  Byeong Cheol SONG ,  Sol KIM ,  Hye Won KIM

Inventor： Jin Sook CHANG ,  Jae Hyun JO ,  Hyun Ae BAE ,  Byeong Cheol SONG ,  Sol KIM ,  Hye Won KIM

IPC: C12P13/12 ,  C12N1/21

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.

Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性和提高磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶活性的微生物来生产半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。

公开(公告)号：US20110111466A1

公开(公告)日：2011-05-12

申请号：US12743675

申请日：2010-02-11

Applicant: Jae Yeong Ju ,  Kwang Ho Lee ,  Hyun Ae Bae ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang ,  Kyu Soo Cho ,  Hye Min Park ,  Hyun Ah Kim

Inventor： Jae Yeong Ju ,  Kwang Ho Lee ,  Hyun Ae Bae ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang ,  Kyu Soo Cho ,  Hye Min Park ,  Hyun Ah Kim

IPC: C12P13/22 ,  C12N1/21 ,  C12P13/08 ,  C12P13/06 ,  C12P13/12

CPC classification number: C12P13/04 ,  C12N9/1205 ,  C12N9/2488 ,  C12Y207/01007 ,  C12Y302/01048

Abstract: The present invention relates to a transformed microorganism producing an L-amino acid using sucrose as a main carbon source, and a method for producing an L-amino acid using the same.

Abstract translation: 本发明涉及使用蔗糖作为主要碳源产生L-氨基酸的转化微生物，以及使用该氨基酸生产L-氨基酸的方法。

公开(公告)号：US09267161B2

公开(公告)日：2016-02-23

申请号：US14007941

申请日：2012-04-02

Applicant: Hyun Won Bae ,  Hyung Joon Kim ,  Jun Ok Moon ,  Jae Woo Jang ,  Jong Chul Kim ,  Tae Han Kim ,  Jin Suck Sung ,  Kyung Han Lee ,  Dae Cheol Kim ,  Hyo Jin Kim ,  Hyun Ae Bae ,  Sang Jo Lim

Inventor： Hyun Won Bae ,  Hyung Joon Kim ,  Jun Ok Moon ,  Jae Woo Jang ,  Jong Chul Kim ,  Tae Han Kim ,  Jin Suck Sung ,  Kyung Han Lee ,  Dae Cheol Kim ,  Hyo Jin Kim ,  Hyun Ae Bae ,  Sang Jo Lim

IPC: C12P13/14 ,  C12N9/12 ,  C12P13/04 ,  C12P13/08

CPC classification number: C12P13/14 ,  C12N9/1205 ,  C12P13/04 ,  C12P13/08 ,  C12Y207/01004

Abstract: The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.

Abstract translation: 本发明涉及棒状杆菌属 用Escherichia sp.衍生的果糖激酶基因转化以表达果糖激酶，其显示出将果糖转化为果糖-6-磷酸的足够活性，从而防止不必要的能量消耗，以及使用该菌株产生L-氨基酸的方法。 转化的棒状杆菌属 本发明能够从来自大肠杆菌的果糖激酶基因中表达果糖激酶，以防止在果糖代谢期间不必要的能量消耗，导致L-氨基酸的更具成本效益的生产。 因此，可广泛用于L-氨基酸的有效生产。

公开(公告)号：US08557549B2

公开(公告)日：2013-10-15

申请号：US13278105

申请日：2011-10-20

Applicant: Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim

Inventor： Jin Sook Chang ,  Jae Hyun Jo ,  Hyun Ae Bae ,  Byeong Cheol Song ,  Sol Kim ,  Hye Won Kim

IPC: C12P13/12

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.

Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性和提高磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶活性的微生物来生产半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。

公开(公告)号：US20120252078A1

公开(公告)日：2012-10-04

申请号：US13254078

申请日：2010-02-16

Applicant: Jae Yeong Ju ,  Kwang Ho Lee ,  Hyun Ae Bae

Inventor： Jae Yeong Ju ,  Kwang Ho Lee ,  Hyun Ae Bae

IPC: C12P13/04 ,  C12P13/08 ,  C12N1/21

CPC classification number: C12Y302/01048 ,  C12N9/2402 ,  C12P13/04

Abstract: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. with sucrose assimilability and L-amino acid producing ability is obtained by introducing a gene encoding a sucrose assimilative microorganism-derived sucrose metabolic enzyme to the sucrose non-assimilative microorganism belonging to the genus Escherichia sp. having an L-amino acid producing ability.

Abstract translation: 本发明涉及属于埃希氏菌属的微生物。 以及使用其制造L-氨基酸的方法。 属于埃希氏菌属的微生物 通过将编码蔗糖同化微生物的蔗糖代谢酶的基因导入属于埃希氏菌属的蔗糖非同化微生物得到蔗糖同化性和L-氨基酸产生能力。 具有L-氨基酸生产能力。