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公开(公告)号：US09689009B2
公开(公告)日：2017-06-27
申请号：US13278106
申请日：2011-10-20
Applicant: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
Inventor： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
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2.发明申请MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME 审中-公开生产O-磷酸的微生物及其使用其的O-磷酸酯生产L-胞嘧啶或其衍生物的方法公开(公告)号：US20120190081A1
公开(公告)日：2012-07-26
申请号：US13278102
申请日：2011-10-20
Applicant: Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
Inventor： Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.
Abstract translation: 本发明提供了通过培养具有降低的内源磷酸丝氨酸磷酸酶活性的微生物来制备半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。
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3.发明申请CORYNEBACTERIUM SP. TRANSFORMED WITH A FRUCTOKINASE GENE DERIVED FROM ESCHERICHIA SP. AND PROCESS FOR PREPARING L-AMINO ACID USING THE SAME 有权红霉素 用来自ESCHERICHIA SP的FRUCTOKINASE基因转化。 和使用该方法制备L-氨基酸的方法和方法公开(公告)号：US20140099680A1
公开(公告)日：2014-04-10
申请号：US14007941
申请日：2012-04-02
Applicant: Hyun Won Bae , Hyung Joon Kim , Jun Ok Moon , Jae Woo Jang , Jong Chul Kim , Tae Han Kim , Jin Suck Sung , Kyung Han Lee , Dae Cheol Kim , Hyo Jin Kim , Hyun Ae Bae , Sang Jo Lim
Inventor： Hyun Won Bae , Hyung Joon Kim , Jun Ok Moon , Jae Woo Jang , Jong Chul Kim , Tae Han Kim , Jin Suck Sung , Kyung Han Lee , Dae Cheol Kim , Hyo Jin Kim , Hyun Ae Bae , Sang Jo Lim
CPC classification number: C12P13/14 , C12N9/1205 , C12P13/04 , C12P13/08 , C12Y207/01004
Abstract: The present invention relates to Corynebacterium sp. that is transformed with an Escherichia sp.-derived fructokinase gene to express fructokinase showing a sufficient activity of converting fructose into fructose-6-phosphate, thereby preventing unnecessary energy consumption, and a method for producing L-amino acids using the strain. The transformed Corynebacterium sp. of the present invention is able to express fructokinase from the Escherichia-derived fructokinase gene to prevent unnecessary energy consumption during fructose metabolism, leading to more cost-effective production of L-amino acids. Therefore, it can be widely used for the effective production of L-amino acids.
Abstract translation: 本发明涉及棒状杆菌属 用Escherichia sp.衍生的果糖激酶基因转化以表达果糖激酶，其显示出将果糖转化为果糖-6-磷酸的足够活性，从而防止不必要的能量消耗，以及使用该菌株产生L-氨基酸的方法。 转化的棒状杆菌属 本发明能够从来自大肠杆菌的果糖激酶基因中表达果糖激酶，以防止在果糖代谢期间不必要的能量消耗，导致L-氨基酸的更具成本效益的生产。 因此，可广泛用于L-氨基酸的有效生产。
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4.发明申请Microorganism Which Produces L-Amino Acid and Method for Producing L-Amino Acid Using the Same 有权生产L-氨基酸的微生物及使用其生产L-氨基酸的方法公开(公告)号：US20120122163A1
公开(公告)日：2012-05-17
申请号：US13254072
申请日：2010-02-16
Applicant: Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae
Inventor： Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae
CPC classification number: C12P13/04 , C07K14/26 , C12N9/1205 , C12P13/08
Abstract: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. has a sucrose assimilability and L-amino acid producing ability, which is obtained by introducing a gene encoding a sucrose assimilative microorganism-derived sucrose metabolic enzyme to sucrose non-assimilative microorganism belonging to the genus Escherichia sp. having an L-amino acid producing ability and sucrose PTS (phosphoenolpyruvate dependent sucrose phosphotransferase system) activity.
Abstract translation: 本发明涉及属于埃希氏菌属的微生物。 以及使用其制造L-氨基酸的方法。 属于埃希氏菌属的微生物 具有蔗糖同化性和L-氨基酸产生能力，其通过将编码蔗糖同化微生物的蔗糖代谢酶的基因导入属于埃希氏菌属的蔗糖非同化微生物而获得。 具有L-氨基酸生产能力和蔗糖PTS（磷酸烯醇丙酮酸依赖性蔗糖磷酸转移酶系统）活性。
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5.发明申请Process for Producing Fermentation Product from Carbon Sources Containing Glycerol using Corynebacteria 有权使用棒杆菌从含有甘油的碳源生产发酵产物的方法公开(公告)号：US20100129884A1
公开(公告)日：2010-05-27
申请号：US12522304
申请日：2008-01-22
Applicant: Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
Inventor： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
CPC classification number: C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
Abstract: The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
Abstract translation: 本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。 更具体地说，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并累积工业上有用的氨基，从含有甘油或一部分甘油的甘油或一部分甘油产生发酵产物的方法 培养基中的酸。
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Patent Agency Ranking
公开(公告)号：US20090325243A1
公开(公告)日：2009-12-31
申请号：US12308810
申请日：2007-06-26
Applicant: Young Hoon Park , Kwang Myung Cho , Yong Uk Shin , Hyun Ae Bae , Jin Sook Chang , Jae Yeong Ju
Inventor： Young Hoon Park , Kwang Myung Cho , Yong Uk Shin , Hyun Ae Bae , Jin Sook Chang , Jae Yeong Ju
CPC classification number: C12P13/08 , C07K14/245 , C12N1/32 , C12P13/04 , C12P13/12
Abstract: The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel production, glycerol, thereby substituting a cheaper material for the conventional fermentation materials such as glucose.
Abstract translation: 本发明涉及能够同时利用甘油作为碳源的氨基酸生产微生物，微生物的制备方法和使用该微生物的氨基酸的制造方法。 根据本发明，可以使用生物柴油生产的副产物甘油有效地生产氨基酸，从而用较便宜的原料代替常规发酵材料如葡萄糖。
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7.发明授权Microorganism which produces L-amino acid and method for producing L-amino acid using the same 有权产生L-氨基酸的微生物和使用其生产L-氨基酸的方法公开(公告)号：US08623620B2
公开(公告)日：2014-01-07
申请号：US13254072
申请日：2010-02-16
Applicant: Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae
Inventor： Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae
IPC: C12N9/24
CPC classification number: C12P13/04 , C07K14/26 , C12N9/1205 , C12P13/08
Abstract: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. has a sucrose assimilability and L-amino acid producing ability, which is obtained by introducing a gene encoding a sucrose assimilative microorganism-derived sucrose metabolic enzyme to sucrose non-assimilative microorganism belonging to the genus Escherichia sp. having an L-amino acid producing ability and sucrose PTS (phosphoenolpyruvate dependent sucrose phosphotransferase system) activity.
Abstract translation: 本发明涉及属于埃希氏菌属的微生物。 以及使用其制造L-氨基酸的方法。 属于埃希氏菌属的微生物 具有蔗糖同化性和L-氨基酸产生能力，其通过将编码蔗糖同化微生物的蔗糖代谢酶的基因导入属于埃希氏菌属的蔗糖非同化微生物而获得。 具有L-氨基酸生产能力和蔗糖PTS（磷酸烯醇丙酮酸依赖性蔗糖磷酸转移酶系统）活性。
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8.发明授权Microorganisms for producing L-amino acids and process for producing L-amino acids using them 有权用于生产L-氨基酸的微生物和使用它们生产L-氨基酸的方法公开(公告)号：US08574874B2
公开(公告)日：2013-11-05
申请号：US12743675
申请日：2010-02-11
Applicant: Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae , Hyo Jin Kim , Keun Chul Lee , Young Bin Hwang , Kyu Soo Cho , Hye Min Park , Hyun Ah Kim
Inventor： Jae Yeong Ju , Kwang Ho Lee , Hyun Ae Bae , Hyo Jin Kim , Keun Chul Lee , Young Bin Hwang , Kyu Soo Cho , Hye Min Park , Hyun Ah Kim
IPC: C12P13/22
CPC classification number: C12P13/04 , C12N9/1205 , C12N9/2488 , C12Y207/01007 , C12Y302/01048
Abstract: The present invention relates to a transformed microorganism producing an L-amino acid using sucrose as a main carbon source, and a method for producing an L-amino acid using the same.
Abstract translation: 本发明涉及使用蔗糖作为主要碳源生产L-氨基酸的转化微生物，以及使用该氨基酸生产L-氨基酸的方法。
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9.发明授权Process for producing fermentation product from carbon sources containing glycerol using Corynebacteria 有权使用棒杆菌从含有甘油的碳源生产发酵产物的方法公开(公告)号：US08426165B2
公开(公告)日：2013-04-23
申请号：US12522304
申请日：2008-01-22
Applicant: Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
Inventor： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
IPC: C12N15/00
CPC classification number: C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
Abstract: The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
Abstract translation: 本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。 更具体地说，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并累积工业上有用的氨基，从含有甘油或一部分甘油的甘油或一部分甘油产生发酵产物的方法 培养基中的酸。
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10.发明申请MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME 有权生产O-磷酸的微生物及其使用其的O-磷酸酯生产L-胞嘧啶或其衍生物的方法公开(公告)号：US20120190083A1
公开(公告)日：2012-07-26
申请号：US13278106
申请日：2011-10-20
Applicant: Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM , Hye Won UM , Sung Hoo JHON , Yong Uk SHIN , Eun Bin YANG , Kyoung Min LEE , Soo An SHIN
Inventor： Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM , Hye Won UM , Sung Hoo JHON , Yong Uk SHIN , Eun Bin YANG , Kyoung Min LEE , Soo An SHIN
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性的微生物来生产半胱氨酸或其衍生物的方法，并且PhnC，PhnD和PhnE的活性降低，并且提高了磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶的活性。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 本文还提供了具有上述这些降低和增强性能的微生物。
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