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    Automatic image analysis method for automatically recognizing at least one rare characteristic
    17.
    发明授权
    Automatic image analysis method for automatically recognizing at least one rare characteristic 有权

    公开(公告)号：US12223700B2

    公开(公告)日：2025-02-11

    申请号：US17610098

    申请日：2020-05-07

    Applicant: UNIVERSITE DE BREST ,  INSERM

    Inventor： Gwenolé Quellec

    IPC: G06V10/82 ,  G06N3/045 ,  G06T7/73 ,  G06V10/74 ,  G06V10/77

    Abstract: Disclosed is an automatic image analysis method that can be used to automatically recognise at least one rare characteristic in an image to be analysed. The method comprises a learning phase during which at least one convolutional neural network is trained to recognise characteristics, a parameter space of dimension n, in which n≥2, is constructed from at least one intermediate layer of the network, a presence probability function is determined for each characteristic in the parameter space from a projection of reference images in the parameter space. During a phase of analysing the image to be analysed, the method comprises a step of recognising the at least one rare characteristic in the image to be analysed on the basis of the presence probability function determined for the at least one rare characteristic.

    Treatment of women affected with polycystic ovary syndrome
    18.
    发明授权
    Treatment of women affected with polycystic ovary syndrome 有权

    公开(公告)号：US12208130B2

    公开(公告)日：2025-01-28

    申请号：US16490228

    申请日：2018-03-14

    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ DE LILLE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE

    Inventor： Paolo Giacobini ,  Vincent Prevot

    IPC: A61K38/09 ,  A61K31/7105 ,  A61K45/06

    Abstract: The present invention relates to the field of therapeutic treatment of polycystic ovary syndrome (PCOS). Polycystic ovary syndrome, PCOS, is the most common female reproductive disorder against which no therapeutic solution is available, beyond changes in the lifestyle. The inventors have now shown by using in vivo preclinical models, that individuals affected with PCOS have an abnormal elevated production of GnRH and that this elevated production of GnRH was transmitted to their offspring that also develop PCOS. Further, by examining AMH levels in a cohort of pregnant PCOS and control women, the inventors have found that AMH concentrations are significantly higher in PCOS women as compared to healthy women during the second trimester of gestation. These unexpected findings has allowed conceiving both prevention and treatment therapeutic strategies based on the administration of GnRH antagonists. Especially, the present invention relates to a gonadotropin-releasing hormone (GnRH) antagonist for its use in a woman affected with polycystic ovary syndrome (PCOS) for preventing the occurrence of PCOS in the offspring of the said woman. Even more interestingly, the present invention relates to a gonadotropin-releasing hormone (GnRH) antagonist for its use to rescue ovulation and fertility in postpuberal PCOS affected individuals.

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