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公开(公告)号：US20110130401A1
公开(公告)日：2011-06-02
申请号：US12784813
申请日：2010-05-21
IPC分类号： A61K31/505 , C07D401/12 , C07D239/48 , C07D403/12 , C07D413/12 , A61K31/506 , A61K31/496 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D405/12
摘要： Compounds of general formula (1) wherein A, B, R1 to R5, Rx m, n and p are defined as described in the specification, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and the use thereof [as] medicaments.
摘要翻译： 其中A，B，R1至R5，Rx m，n和p的通式（1）的化合物如本说明书所述定义，其适用于治疗特征为过度或异常细胞增殖的疾病，其含有 这些化合物及其用作药物。
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12.发明申请公开(公告)号：US20140371205A1
公开(公告)日：2014-12-18
申请号：US14472627
申请日：2014-08-29
IPC分类号： C07D239/47 , C07D401/14 , C07D493/04 , C07D401/12 , C07D405/12 , C07D419/14 , C07D403/12 , C07D405/14
CPC分类号： C07D413/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D419/14 , C07D493/04
摘要： The present invention encompasses compounds of general formula (1) wherein A, B, X, R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，B，X，R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备 具有上述特性的药物。
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公开(公告)号：US08889665B2
公开(公告)日：2014-11-18
申请号：US12665769
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/55 , A61K31/535 , A61K31/497 , A61K31/44 , A61K31/415 , C07D403/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D487/08 , C07D417/14 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3和L基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物 具有上述性质。
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公开(公告)号：US20140051674A1
公开(公告)日：2014-02-20
申请号：US14060859
申请日：2013-10-23
IPC分类号： C07D405/12 , A61K31/506 , C07D239/48 , A61K45/06 , C07D403/12 , C07D401/14 , A61K31/5377 , C07D401/12 , A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12
摘要： The present invention encompasses compounds of general formula (1) wherein B, R1 to R5, Rx, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use in such treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中B，R 1至R 5，R x，m和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 这样的治疗。
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公开(公告)号：US08466155B2
公开(公告)日：2013-06-18
申请号：US12893240
申请日：2010-09-29
IPC分类号： C07D239/47 , C07D403/12 , A61K31/496
CPC分类号： C07D239/47 , C07D403/12 , C07D417/12
摘要： The present invention encompasses compounds of general formulae (1a) and (1b) wherein the groups R1 to R5, A, Q, m, n, p and q are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments.
摘要翻译： 本发明包括通式（1a）和（1b）的化合物，其中基团R 1至R 5，A，Q，m，n，p和q如权利要求1所定义，其适用于治疗以 过度或异常的细胞增殖，以及它们作为药物的用途。
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公开(公告)号：US20100240657A1
公开(公告)日：2010-09-23
申请号：US12665776
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Martin Steegmaier , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Martin Steegmaier , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/5377 , C07C63/64 , A61K31/192 , C07D401/04 , A61K31/4439 , C07D277/22 , A61K31/427 , C07D263/32 , A61K31/422 , C07D249/06 , A61K31/4196 , C07D403/04 , A61K31/506 , C07D471/04 , A61K31/437 , C07C307/02 , A61K31/18 , C07D413/14 , A61K31/497 , C07C69/78 , A61K31/235 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 制备具有上述性质的药物组合物。
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公开(公告)号：US08785464B2
公开(公告)日：2014-07-22
申请号：US14049575
申请日：2013-10-09
IPC分类号： C07D401/12 , C07D401/14 , A61K31/505
CPC分类号： C07D417/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： The present invention includes compounds of general formula (1) wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，R 1和R 2如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，及其用于制备具有 上述属性。
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公开(公告)号：US08410126B2
公开(公告)日：2013-04-02
申请号：US12784813
申请日：2010-05-21
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D401/12 , C07D239/48 , C07D405/12
摘要： Compounds of general formula (1) wherein A, B, R1 to R5, Rx m, n and p are defined as described in the specification, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and the use thereof [as] medicaments.
摘要翻译： 其中A，B，R1至R5，Rx m，n和p的通式（1）的化合物如本说明书所述定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，其含有 这些化合物及其用作药物。
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公开(公告)号：US08198308B2
公开(公告)日：2012-06-12
申请号：US12946069
申请日：2010-11-15
申请人： Steffen Steurer , Peter Ettmayer , Andreas Mantoulidis , Ioannis Sapountzis , Martin Steegmaier
发明人： Steffen Steurer , Peter Ettmayer , Andreas Mantoulidis , Ioannis Sapountzis , Martin Steegmaier
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用途 用于制备具有上述性质的药物。
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公开(公告)号：US20110071158A1
公开(公告)日：2011-03-24
申请号：US12723782
申请日：2010-03-15
IPC分类号： A61K31/496 , C07D401/12 , A61K31/506 , C07D239/48 , A61K31/505 , C07D403/12 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12
摘要： The present invention encompasses compounds of general formula (1) wherein B, R1 to R5, Rx, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use in such treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中B，R 1至R 5，R x，m和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 这样的治疗。
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