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公开(公告)号：US20110071158A1
公开(公告)日：2011-03-24
申请号：US12723782
申请日：2010-03-15
IPC分类号： A61K31/496 , C07D401/12 , A61K31/506 , C07D239/48 , A61K31/505 , C07D403/12 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12
摘要： The present invention encompasses compounds of general formula (1) wherein B, R1 to R5, Rx, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use in such treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中B，R 1至R 5，R x，m和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 这样的治疗。
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公开(公告)号：US20140371205A1
公开(公告)日：2014-12-18
申请号：US14472627
申请日：2014-08-29
IPC分类号： C07D239/47 , C07D401/14 , C07D493/04 , C07D401/12 , C07D405/12 , C07D419/14 , C07D403/12 , C07D405/14
CPC分类号： C07D413/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D419/14 , C07D493/04
摘要： The present invention encompasses compounds of general formula (1) wherein A, B, X, R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，B，X，R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备 具有上述特性的药物。
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公开(公告)号：US20140051674A1
公开(公告)日：2014-02-20
申请号：US14060859
申请日：2013-10-23
IPC分类号： C07D405/12 , A61K31/506 , C07D239/48 , A61K45/06 , C07D403/12 , C07D401/14 , A61K31/5377 , C07D401/12 , A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12
摘要： The present invention encompasses compounds of general formula (1) wherein B, R1 to R5, Rx, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use in such treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中B，R 1至R 5，R x，m和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 这样的治疗。
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公开(公告)号：US20140038993A1
公开(公告)日：2014-02-06
申请号：US14049575
申请日：2013-10-09
IPC分类号： C07D417/14 , C07D401/14 , C07D413/14 , C07D403/12 , C07D239/47 , C07D401/12 , C07D405/14
CPC分类号： C07D417/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： The present invention includes compounds of general formula (1) wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，R 1和R 2如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，及其用于制备具有 上述属性。
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公开(公告)号：US20090163465A1
公开(公告)日：2009-06-25
申请号：US12366075
申请日：2009-02-05
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/506 , A61K31/55 , A61K31/553 , A61K31/551 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号：US20130281429A1
公开(公告)日：2013-10-24
申请号：US13850711
申请日：2013-03-26
申请人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
发明人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
IPC分类号： C07D239/48 , C07D401/14 , C07D401/12 , C07D487/08 , A61K31/5377 , A61K45/06 , A61K31/506 , A61K31/505 , A61K31/551 , C07D403/12 , C07D409/14
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物组合物的用途 提到的属性。
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公开(公告)号：US20090149438A1
公开(公告)日：2009-06-11
申请号：US12366078
申请日：2009-02-05
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/5377 , C07D413/14 , C07D403/12 , A61K31/506 , A61K31/551 , C07D409/14 , A61K31/553
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号：US20110251174A1
公开(公告)日：2011-10-13
申请号：US13159787
申请日：2011-06-14
申请人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
发明人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
IPC分类号： A61K31/506 , A61K31/505 , C07D403/12 , A61K31/551 , C07D413/14 , A61P35/00 , C07D401/14 , C07D401/12 , C07D413/12 , C07D487/08 , C07D409/14 , C07D239/48 , A61K31/5377
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物组合物的用途 提到的属性。
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公开(公告)号：US20110086842A1
公开(公告)日：2011-04-14
申请号：US12972976
申请日：2010-12-20
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/553 , A61K31/506 , A61K31/5355 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，W，X，Y，Z，Ra，Rb，Rc，R 1和R 3如权利要求1中所定义，其适用于治疗以过量 或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。
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