公开(公告)号：US5932234A

公开(公告)日：1999-08-03

申请号：US962444

申请日：1997-10-31

Applicant: Pascal Simon ,  Dominique Bordeaux ,  Isabelle Afriat

Inventor： Pascal Simon ,  Dominique Bordeaux ,  Isabelle Afriat

IPC: A61K8/30 ,  A01N43/16 ,  A61K8/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/49 ,  A61K8/60 ,  A61K8/66 ,  A61K8/67 ,  A61K8/73 ,  A61K8/86 ,  A61K8/92 ,  A61K8/97 ,  A61K31/23 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q19/00 ,  A61Q19/04 ,  A61K7/00 ,  A01N43/04 ,  A61K7/06

CPC classification number: A61Q19/04 ,  A61K8/042 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/602 ,  A61K8/66 ,  A61K8/92 ,  A61K8/97 ,  A61Q1/14 ,  A61Q19/00 ,  A61K2800/262 ,  Y10S514/941 ,  Y10S514/944

Abstract: Compositions suitable for cosmetic and/or dermatological use which contain a cosmetic and/or dermatological active agent, at least 20% of a fatty phase, a fatty acid ester of a C.sub.5 -C.sub.7 carbohydrate and polyol.

Abstract translation: 适用于化妆品和/或皮肤病学用途的组合物，其含有化妆品和/或皮肤病学活性剂，至少20％的脂肪相，C5-C7碳水化合物的脂肪酸酯和多元醇。

公开(公告)号：US5830449A

公开(公告)日：1998-11-03

申请号：US686922

申请日：1996-07-24

Applicant: Isabelle Afriat ,  Didier Gagnebien

Inventor： Isabelle Afriat ,  Didier Gagnebien

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/14 ,  A61K8/31 ,  A61K8/34 ,  A61K8/66 ,  A61K8/72 ,  A61K8/81 ,  A61K8/89 ,  A61K8/891 ,  A61K8/894 ,  A61K8/898 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61K31/78 ,  A61K7/48

CPC classification number: A61K8/894 ,  A61K8/66 ,  A61K8/92 ,  A61K8/922 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q5/00 ,  A61K2800/52

Abstract: A stable composition for topical application is provided which contains at least one enzyme, at least one polyol, the latter being present in a quantity which is effective for obtaining a water activity value of the composition of less than or equal to 0.85, and at least one structuring agent chosen from polymers and oils, for the purpose of stabilizing the enzyme. In such a composition, the enzyme retains its efficacy over time. The composition obtained can be used for cleansing and/or caring for and/or protecting the skin and/or keratinous fibers.

Abstract translation: 提供用于局部应用的稳定组合物，其包含至少一种酶，至少一种多元醇，后者以有效获得组合物的水活度值小于或等于0.85的量存在，并且至少 选自聚合物和油的一种结构剂，用于稳定酶的目的。 在这种组合物中，该酶保留其随时间的功效。 获得的组合物可用于清洁和/或照顾和/或保护皮肤和/或角质纤维。

公开(公告)号：US07109237B2

公开(公告)日：2006-09-19

申请号：US10218908

申请日：2002-08-15

Applicant: Isabelle Afriat ,  Florence Chanvin

Inventor： Isabelle Afriat ,  Florence Chanvin

IPC: A61K31/40 ,  A61K8/02

CPC classification number: A61Q17/00 ,  A61K8/06 ,  A61K8/064 ,  A61K8/676 ,  A61K8/894 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S514/928

Abstract: A water-in-oil emulsion containing ascorbic acid and, as an emulsifier, a dimethiconecopolyol or an alkyldimethiconecopolyol, where the aqueous phase having a pH ranging from 5.5 to 7.5. This emulsion allows ascorbic acid to be stabilized and can be used, in particular, in the cosmetics and/or dermatological fields. The invention also relates to a cosmetic process for treating the skin using the emulsion.

公开(公告)号：US06465510B2

公开(公告)日：2002-10-15

申请号：US09801755

申请日：2001-03-09

Applicant: Isabelle Afriat ,  Florence Chanvin

Inventor： Isabelle Afriat ,  Florence Chanvin

IPC: A61K3134

CPC classification number: A61Q17/00 ,  A61K8/06 ,  A61K8/064 ,  A61K8/676 ,  A61K8/894 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S514/928

Abstract: A water-in-oil emulsion containing ascorbic acid and, as an emulsifier, a dimethiconecopolyol or an alkyldimethiconecopolyol, where the aqueous phase having a pH ranging from 5.5 to 7.5. This emulsion allows ascorbic acid to be stabilized and can be used, in particular, in the cosmetics and/or dermatological fields. The invention also relates to a cosmetic process for treating the skin using the emulsion.

Abstract translation: 含有抗坏血酸的油包水乳液，以及作为乳化剂的二甲基聚多元醇或烷基二甲基多羟基苯甲醇，其中水相的pH为5.5-7.5。 该乳液使抗坏血酸稳定，特别可用于化妆品和/或皮肤病学领域。 本发明还涉及使用乳液处理皮肤的美容方法。

公开(公告)号：US06328983B1

公开(公告)日：2001-12-11

申请号：US09408448

申请日：1999-09-29

Applicant: Isabelle Afriat

Inventor： Isabelle Afriat

IPC: A61K700

CPC classification number: A61Q17/00 ,  A61K8/676 ,  A61K8/891 ,  A61K2800/52

Abstract: The present invention relates to the use of a silicone gum to stabilize ascorbic acid or one of its esters or salts in a topical composition and to novel compositions comprising these components and having a pH of from 4 to 7. These compositions can be used in the fields of cosmetology, dermatology and veterinary medicine.

Abstract translation: 本发明涉及硅胶在稳定抗坏血酸或其局部组合物中的酯或其盐之一的用途以及包含这些组分并具有4至7的pH的新型组合物。这些组合物可用于 美容，皮肤科，兽医领域。

公开(公告)号：US20070125390A1

公开(公告)日：2007-06-07

申请号：US11296236

申请日：2005-12-07

Applicant: Isabelle Afriat ,  Miriam Rafailovich ,  E. Guan

Inventor： Isabelle Afriat ,  Miriam Rafailovich ,  E. Guan

IPC: A61B19/00 ,  G06K9/00

CPC classification number: A61B5/445 ,  A61B5/0088 ,  A61B5/442

Abstract: The present invention provides non-invasive, in vivo, DISC-type methods of evaluating structural changes in skin due to a variety of exogenous or endogenous factors. It is possible to develop quantitative and qualitative characterizations of skin. For example, the skin may be characterized based on its structural age rather than its chronological age. Based on the structural age and type of an individual's skin, cosmetic, dermatologic, medicinal or manipulative treatment may be customized. The method is based, in part, on quantification of discontinuities that arise in the skin during normal facial expression. The methods provide for evaluating changes in human skin response that occur over a short term (one day) or long term (one or more years). The methods provide for evaluating the skin's response to cosmetic, dermatologic or medicinal treatment or to any other factor alleged to affect the skin.

Abstract translation: 本发明提供了由多种外源或内源因素评价皮肤结构变化的非侵入式体内DISC型方法。 可以开发皮肤的定量和定性表征。 例如，皮肤可以基于其结构年龄而不是其时间年龄来表征。 根据个人皮肤的结构年龄和类型，可以定制化妆品，皮肤病学，药物或操作性治疗。 该方法部分地基于在正常面部表情期间在皮肤中产生的不连续性的量化。 这些方法用于评估短期（一天）或长期（一年或多年）发生的人类皮肤反应变化。 该方法用于评估皮肤对化妆品，皮肤病学或药物治疗的反应或任何其他影响皮肤的因素。

公开(公告)号：US06905695B1

公开(公告)日：2005-06-14

申请号：US09610320

申请日：2000-07-05

Applicant: Isabelle Afriat ,  Virginie Boulier

Inventor： Isabelle Afriat ,  Virginie Boulier

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/19 ,  A61K8/20 ,  A61K8/30 ,  A61K8/31 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/40 ,  A61K8/58 ,  A61K8/67 ,  A61K8/81 ,  A61K8/89 ,  A61K8/891 ,  A61K8/894 ,  A61K8/898 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q19/00 ,  B01F17/54 ,  C08G81/00 ,  C08K3/00 ,  C08K5/00 ,  C08L83/04 ,  C08L83/05 ,  C08L83/06 ,  C08L83/12 ,  C08L101/00 ,  A61K7/00

CPC classification number: A61K8/894 ,  A61K8/02 ,  A61K8/06 ,  A61K8/064 ,  A61K8/20 ,  A61K8/585 ,  A61K8/891 ,  A61K8/92 ,  A61K8/922 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/008 ,  B01F17/0071

Abstract: The invention relates to a solid composition in the form of a water-in-oil emulsion. The aqueous phase represents at least 70% by weight with respect to the total weight of the composition. The composition contains at least one silicone emulsifier and at least 3% by weight of at least one wax with respect to the total weight of the composition.

Abstract translation: 本发明涉及一种油包水乳液形式的固体组合物。 水相相对于组合物的总重量为至少70重量％。 所述组合物相对于所述组合物的总重量含有至少一种硅氧烷乳化剂和至少3重量％的至少一种蜡。

公开(公告)号：US06562354B1

公开(公告)日：2003-05-13

申请号：US09611312

申请日：2000-07-06

Applicant: Isabelle Afriat ,  Virginie Boulier

Inventor： Isabelle Afriat ,  Virginie Boulier

IPC: A61K600

CPC classification number: A61K8/894 ,  A61K8/06 ,  A61K8/064 ,  A61K8/20 ,  A61Q1/00 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/008 ,  B01F17/0071 ,  Y10S514/937

Abstract: The present provides a composition that includes, in a physiologically acceptable medium: an aqueous phase dispersed in an oily phase with a silicone emulsifier; wherein the aqueous phase represents at least 80% by weight relative to the total weight of the composition; wherein the silicone emulsifier is an alkyldimethicone copolyol comprising an HLB of less than 8; and wherein a weight ratio of the oily phase to the silicone emulsifier is greater than or equal to 5. The present invention also provides a cosmetic, which includes the above-mentioned composition and methods of using the above-mentioned composition for treating, protecting, caring for, or removing make-up from the skin, lips or hair, cleansing the skin, lips or hair, and making up the skin or lips, treating, protecting, and caring for the scalp, and treating greasy skin. The composition can be used in particular in cosmetics and/or dermatology.

Abstract translation: 本发明提供一种组合物，其在生理学上可接受的培养基中包含：分散在油相中的水相与硅氧烷乳化剂;其中所述水相相对于所述组合物的总重量为至少80重量％;其中所述硅氧烷 乳化剂是包含小于8的HLB的烷基二甲基聚硅氧烷共聚醇; 并且其中油相与硅氧烷乳化剂的重量比大于或等于5.本发明还提供了一种化妆品，其包括上述组合物和使用上述组合物用于处理，保护，保养的方法 用于或从皮肤，嘴唇或头发上除去化妆品，清洁皮肤，嘴唇或头发，以及组合皮肤或嘴唇，治疗，保护和照顾头皮，以及治疗油腻的皮肤。 该组合物特别可用于化妆品和/或皮肤病学。

公开(公告)号：US06503520B1

公开(公告)日：2003-01-07

申请号：US09689768

申请日：2000-10-13

Applicant: Isabelle Afriat

Inventor： Isabelle Afriat

IPC: A61K600

CPC classification number: A61K8/897 ,  A61K8/02 ,  A61K8/027 ,  A61K8/064 ,  A61K8/585 ,  A61K8/8111 ,  A61K8/88 ,  A61K8/891 ,  A61K8/894 ,  A61K8/922 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/00 ,  Y10S514/937

Abstract: A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and-at least one wax. The composition obtained has very good stability and can in particular constitute a cosmetic composition. The invention also relates to the use of the said composition, in particular for caring for, treating, making up or cleansing the skin the lips, the eyelashes and/or the hair.

Abstract translation: 含有纤维，至少一种硅氧烷表面活性剂和至少一种蜡的油包水乳液形式的组合物。所得组合物具有非常好的稳定性，特别可构成化妆品组合物。本发明还涉及 使用所述组合物，特别是用于照顾，治疗，补充或清洁唇部，睫毛和/或头发的皮肤。

公开(公告)号：US06239174B1

公开(公告)日：2001-05-29

申请号：US09145611

申请日：1998-09-02

Applicant: Isabelle Afriat ,  Florence Chanvin

Inventor： Isabelle Afriat ,  Florence Chanvin

IPC: A61K3134

CPC classification number: A61Q17/00 ,  A61K8/06 ,  A61K8/064 ,  A61K8/676 ,  A61K8/894 ,  A61Q19/00 ,  A61Q19/08

Abstract: A water-in-oil emulsion containing ascorbic acid and, as an emulsifier, a dimethiconecopolyol or an alkyldimethiconecopolyol, where the aqueous phase having a pH ranging from 6.1 to 7.5. This emulsion allows ascorbic acid to be stabilized and can be used, in particular, in the cosmetics and/or dermatological fields. The invention also relates to a cosmetic process for treating the skin using the emulsion.

Abstract translation: 含有抗坏血酸的油包水乳液，以及作为乳化剂的二甲基聚多元醇或烷基二甲基表醇多元醇，其中水相的pH为6.1至7.5。 该乳液使抗坏血酸稳定，特别可用于化妆品和/或皮肤病学领域。 本发明还涉及使用乳液处理皮肤的美容方法。