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37 条记录 (耗时 0.016 秒)

    Intravascular device for axially stretching blood vessels
    12.
    发明授权
    Intravascular device for axially stretching blood vessels 有权
    用于轴向拉伸血管的血管内装置

    公开(公告)号：US07300455B2

    公开(公告)日：2007-11-27

    申请号：US11371663

    申请日：2006-03-09

    申请人： Raymond P. Vito ,  Jack C. Griffis, III

    发明人： Raymond P. Vito ,  Jack C. Griffis, III

    IPC分类号： A61F2/06

    CPC分类号： A61F2/88 ,  A61F2/885

    摘要： Intravascular devices are provided for forming a vascular graft by axially distending a blood vessel to induce growth. These devices advantageously can be implanted via a catheter, thereby eliminating the need for a more invasive implantation procedure when the stretching is to be done in vivo. The implantable medical device for distending a blood vessel to induce axial growth of the blood vessel includes an intravascular stretching mechanism securable to an interior luminal surface of a blood vessel in vivo, and a means for operating the intravascular stretching mechanism in vivo to cause the vessel to stretch and grow axially. The stretching mechanism can include a pair of wires or stents that engage the blood vessel wall, and components of the stretching mechanism may include a shape memory material.

    摘要翻译： 提供血管内装置用于通过轴向膨胀血管以诱导生长形成血管移植物。 这些装置有利地可以通过导管植入，从而当拉伸在体内进行时不需要更具侵入性的植入程序。 用于使血管膨胀以引起血管轴向生长的可植入医疗装置包括可固定于体内血管内腔内表面的血管内拉伸机构，以及用于在体内操作血管内拉伸机构以引起血管的装置 拉伸和轴向生长。 拉伸机构可以包括与血管壁接合的一对线或支架，并且拉伸机构的部件可以包括形状记忆材料。

    Devices for creating vascular grafts by vessel distension using rotatable elements
    14.
    发明授权
    Devices for creating vascular grafts by vessel distension using rotatable elements 有权
    用于通过使用可旋转元件的血管扩张产生血管移植物的装置

    公开(公告)号：US06641576B1

    公开(公告)日：2003-11-04

    申请号：US09994500

    申请日：2001-11-27

    申请人： Raymond P. Vito ,  Jack C. Griffis, III

    发明人： Raymond P. Vito ,  Jack C. Griffis, III

    IPC分类号： A61B1700

    CPC分类号： A61F2/06 ,  A61F2/062 ,  Y10S623/903

    摘要： Devices and methods are provided for forming a vascular graft by axially distending a blood vessel to induce growth. The device preferably comprises a stretching mechanism which includes (i) a stabilization rod, (ii) a pair of rotatable elements, wherein each rotatable element is rotatably attached to the elongated body and has a channel substantially perpendicular to the axis of rotation, and (iii) a means for rotating each rotatable element to axially distend a blood vessel positioned in the channels of the rotatable elements. The elements can be rotated intermittently, cyclically, or continuously, over a period to distend or elongate the donor vessel. Preferably, the device is implanted, for example using endoscopic techniques, for use in vivo, although the device also can be used in vitro.

    摘要翻译： 提供了通过轴向膨胀血管以诱导生长来形成血管移植物的装置和方法。 该装置优选地包括拉伸机构，其包括（i）稳定杆，（ii）一对可旋转元件，其中每个可旋转元件可旋转地附接到细长主体并且具有基本上垂直于旋转轴线的通道，和 iii）用于使每个可旋转元件旋转以使位于可旋转元件的通道中的血管轴向膨胀的装置。 元件可以在一段时间内间歇地，循环地或连续地旋转以膨胀或延长供体容器。 优选地，该装置例如使用内窥镜技术植入体内使用，尽管该装置也可以在体外使用。

    Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
    15.
    发明授权
    Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods 有权
    用于治疗老花眼和其他眼睛疾病的巩膜假体及相关装置和方法

    公开(公告)号：US08337550B2

    公开(公告)日：2012-12-25

    申请号：US12960917

    申请日：2010-12-06

    申请人： Jack C. Griffis, III

    发明人： Jack C. Griffis, III

    IPC分类号： A61F2/14

    CPC分类号： A61F2/147 ,  A61F2/148 ,  A61F2210/0023

    摘要： One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

    摘要翻译： 一个例子是巩膜假体包括第一自由端和第二自由端，每个宽度大于巩膜假体的中间部分。 多个第一部分形成巩膜假体的第一端。 第一部分沿巩膜假体长度的至少一半分开。 多个第二部分可以形成巩膜假体的第二端，并且第二部分可以沿着巩膜假体的长度的小于四分之一分开。 可以使用植入装置来促进巩膜假体的植入。 植入装置包括构造成插入到眼睛的巩膜隧道中的第一端部。 植入装置还包括构造成接收巩膜假体的第二端部。 具有锥形和圆形端的杆可以部分地插入植入装置的第一端部。

    Method and system for mitigating effects of biomechanical forces on cell, particle and drug based therapies
    16.
    发明授权
    Method and system for mitigating effects of biomechanical forces on cell, particle and drug based therapies 有权
    减轻生物力学对细胞，颗粒和药物治疗效果的方法和系统

    公开(公告)号：US08197462B1

    公开(公告)日：2012-06-12

    申请号：US12454396

    申请日：2009-05-18

    申请人： Raymond P. Vito ,  Michael L. Wach ,  Jack C. Griffis, III ,  W. Robert Taylor

    发明人： Raymond P. Vito ,  Michael L. Wach ,  Jack C. Griffis, III ,  W. Robert Taylor

    IPC分类号： A61M31/00

    CPC分类号： A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2034/102 ,  G06F19/00

    摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.

    摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。