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    ANTI-INFLAMMATORY PROTEINS AND METHODS OF USE
    15.
    发明申请
    ANTI-INFLAMMATORY PROTEINS AND METHODS OF USE 审中-公开
    抗炎蛋白质和使用方法

    公开(公告)号：US20160235813A1

    公开(公告)日：2016-08-18

    申请号：US15023108

    申请日：2014-09-18

    Applicant: JAMES COOK UNIVERSITY

    Inventor： Cinzia Cantacessi ,  Alex Loukas

    IPC: A61K38/17 ,  A61K45/06

    CPC classification number: A61K38/1767 ,  A61K38/1709 ,  A61K38/57 ,  A61K45/06

    Abstract: A method and composition for reducing or alleviating inflammation in a subject is provided, including administering to the subject a therapeutically effective amount; of one or more isolated proteins respectively comprising an amino acid sequence set forth in SEQ ID NOS:1-31, or a biologically active fragment or variant thereof or combinations of these to thereby reduce or alleviate inflammation. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

    Abstract translation: 提供了用于减少或减轻受试者的炎症的方法和组合物，包括向受试者施用治疗有效量; 分别包含SEQ ID NO：1-31所示的氨基酸序列的一个或多个分离的蛋白质，或其生物活性片段或变体或它们的组合，从而减少或减轻炎症。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。

    METHOD FOR TREATING INFLAMMATION
    16.
    发明申请
    METHOD FOR TREATING INFLAMMATION 有权
    治疗炎症的方法

    公开(公告)号：US20150037366A1

    公开(公告)日：2015-02-05

    申请号：US14384681

    申请日：2013-03-13

    Applicant: JAMES COOK UNIVERSITY

    Inventor： Alex Loukas ,  Severine Navarro

    IPC: C07K14/435 ,  A61K39/00 ,  A61K45/06

    CPC classification number: C07K14/4354 ,  A61K38/57 ,  A61K39/0003 ,  A61K45/06

    Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.

    Abstract translation: 用于减轻或减轻受试者炎症的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而减少或缓解受试者的炎症。 用于预防或治疗受试者哮喘或炎症性肠病的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而预防或治疗受试者的哮喘或炎症性肠病。 受试者可以是哺乳动物，包括人类。

    Food grade wax and process for preparing same
    17.
    发明申请
    Food grade wax and process for preparing same 审中-公开
    食品级蜡及其制备方法

    公开(公告)号：US20040076732A1

    公开(公告)日：2004-04-22

    申请号：US10682513

    申请日：2003-10-10

    Applicant: JAMES COOK UNIVERSITY ,  CSR LIMITED

    Inventor： Marjorie Gan Valix

    IPC: A23D007/00

    CPC classification number: A23G4/066 ,  A23C19/163 ,  A23D9/007 ,  A23G3/346 ,  A23G4/068 ,  A23G4/08 ,  A23G2200/08 ,  A23P20/11 ,  C11B11/00

    Abstract: The invention provides a wax composition which can be used in comestibles. The wax composition is obtained from sugar cane and comrpises wax esters, aldehydes, tri-glycerides, alcohols, free fatty acids, sterols and polar lipids. A process for preparing a wax composition from crude sugar cane wax, the process comprising the steps of: (i) heating a solution of the crude wax with a lower alcohol as sovlent at the boiling point of the solvent; (ii) allowing phase separation of the solution from (i) and decanting the upper phase while hot; (iii) allowing the separated phase from (ii) to cool and separating crystallised wax from the solvent; (iv) repeating steps (i) to (iii) using the wax from (iii) until all pitch has been removed from the wax; (v) heating the wax to between 90 and 140null C. and oxidising molten wax with oxidizing material; and (vi) continuing the heating under and inert gas on completion of the oxidation step until intermediate peroxide products are removed.

    Abstract translation: 本发明提供了可用于食品中的蜡组合物。 蜡组合物由甘蔗和蜡酯，醛，三甘油酯，醇，游离脂肪酸，甾醇和极性脂质得到。 一种由粗甘蔗蜡制备蜡组合物的方法，该方法包括以下步骤：（i）在溶剂的沸点下将粗蜡与低级醇溶液一起加热; （ii）允许溶液与（i）的相分离并在热的同时倾析上相; （iii）允许来自（ii）的分离相冷却并将结晶的蜡与溶剂分离; （iv）使用来自（iii）的蜡重复步骤（i）至（iii），直到所有沥青从蜡中除去; （v）将蜡加热至90-140℃，用氧化材料氧化熔融蜡; 和（vi）在氧化步骤完成时继续加热和惰性气体，直至除去中间体过氧化物产物。

    MODIFIED ANTI-INFLAMMATORY PROTEINS AND METHOD OF USE
    18.
    发明申请
    MODIFIED ANTI-INFLAMMATORY PROTEINS AND METHOD OF USE 有权

    公开(公告)号：US20240400649A1

    公开(公告)日：2024-12-05

    申请号：US18414112

    申请日：2024-01-16

    Applicant: James Cook University

    Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

    IPC: C07K14/81 ,  A61K38/00 ,  A61K38/57 ,  A61K45/06 ,  C07K14/435

    Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

    Modified anti-inflammatory proteins and method of use
    20.
    发明授权
    Modified anti-inflammatory proteins and method of use 有权

    公开(公告)号：US10822395B2

    公开(公告)日：2020-11-03

    申请号：US15023165

    申请日：2014-09-18

    Applicant: James Cook University

    Inventor： Alex Loukas ,  Andrew Leech ,  Darren Pickering

    IPC: A61K38/00 ,  A61P29/00 ,  A61K38/16 ,  A61P11/06 ,  C07K14/81 ,  A61K45/06 ,  C07K14/435 ,  A61K38/57

    Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.

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