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    Post attachment device
    13.
    发明申请
    Post attachment device 有权
    后附件装置

    公开(公告)号：US20050015946A1

    公开(公告)日：2005-01-27

    申请号：US10627066

    申请日：2003-07-25

    Applicant: James Downing ,  Samuel Tidwell ,  Steve Caldwell

    Inventor： James Downing ,  Samuel Tidwell ,  Steve Caldwell

    IPC: A42B3/04 ,  A44B11/25

    CPC classification number: A42B3/0473 ,  Y10T24/45597 ,  Y10T24/4599

    Abstract: A post attachment device for connecting a helmet to a head and neck support. The device includes a post anchor having a base, a button, a resilient member, a post, a retainer and a catch having a slot with a larger first section connected by a channel to a smaller second section. The button is positioned in an indention in the base with the resilient member positioned therebetween. The post extends through the button, the base and the helmet. The retainer is secured on the post adjacent the inner surface of the helmet. To secure the post attachment device, the catch is orientated over the post. The button is then depressed into the base while the catch is moved backwards to move the post into the second section of the slot.

    Abstract translation: 一种用于将头盔连接到头颈部支撑件的后附接装置。 该装置包括具有底座，按钮，弹性构件，柱，保持器和具有狭槽的支柱锚，该槽具有较大的第一部分，该第一部分通过通道连接到较小的第二部分。 该按钮位于基座中的一个凹口中，其中弹性构件位于它们之间。 该柱延伸穿过按钮，基座和头盔。 保持器固定在邻近头盔内表面的柱上。 为了固定柱附件装置，捕获物定向在柱上。 然后将按钮压入基座，同时将卡扣向后移动以将柱移动到槽的第二部分中。

    InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof
    14.
    发明授权
    InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof 失效
    InK4c-p18和InK4d-p19，细胞周期蛋白依赖性激酶CDK4和CDK6的抑制剂及其用途

    公开(公告)号：US6033847A

    公开(公告)日：2000-03-07

    申请号：US384106

    申请日：1995-02-06

    Applicant: Charles J. Sherr ,  James Downing ,  Hiroshi Hirai ,  Tsukasa Okuda

    Inventor： Charles J. Sherr ,  James Downing ,  Hiroshi Hirai ,  Tsukasa Okuda

    IPC: G01N33/53 ,  A61K31/70 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/52 ,  C07K16/24 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/574 ,  C07H21/00 ,  C07K14/435 ,  C12N15/85

    CPC classification number: C07K14/47 ,  A01K2217/05 ,  C07K2319/00

    Abstract: Members of the InK4 (Inhibitors of CDK4) family inhibit the activities of specific cyclin D-dependent kinases (CDK4 and/or CDK6), thereby arresting cell cycle progression in G1 phase and preventing chromosomal DNA replication. Disclosed herein are novel mammalian InK4 family members, having apparent molecular masses of 18,000 and 19,000 daltons, designated "InK4c-p18" and "InK4d-p19," respectively, or simply "p18" and "p19." In particular, the invention provides p19 genes and proteins isolated from murine or human cells and p18 genes and proteins from murine cells. When constitutively expressed in cells, p19 inhibits cyclin D-dependent kinase activity in vivo and induces G1 phase arrest. Materials and methods disclosed herein include (1) nucleic acids that encode p18 or p19; (2) methods for detecting nucleic acids encoding p18 or p19 proteins; (3) methods for producing p18 or p19 proteins using nucleic acids that encode p18 or p19, respectively; (4) purified pl8 or p19 proteins and peptide fragments, oligopeptides, or fusion proteins derived therefrom; (5) methods of inhibiting cells from replicating their chromosomal DNA using purified p18 or p19 proteins or derivatives thereof; (6) antibodies that specifically bind p18 or p19; (7) methods for detecting p18 and p19 proteins; (8) methods of stimulating cell growth by blocking p18 or p19 expression via antisense oligonucleotides; (9) methods of gene therapy using nucleic acids that encode p18 or p19; and (10) methods of making transgenic non-human animals that have alterations in the gene encoding p18 or p19, or in both genes.

    Abstract translation: InK4（CDK4抑制剂）家族的成员抑制特异性细胞周期蛋白D依赖性激酶（CDK4和/或CDK6）的活性，从而阻止G1期的细胞周期进程并防止染色体DNA复制。 本文公开了新颖的哺乳动物InK4家族成员，其分子量分别为18,000和19,000道尔顿，分别称为“InK4c-p18”和“InK4d-p19”，或简称为“p18”和“p19”。 特别地，本发明提供从鼠或人细胞分离的p19基因和蛋白质，以及来自鼠细胞的p18基因和蛋白质。 当细胞中组成型表达时，p19在体内抑制细胞周期蛋白D依赖性激酶活性，并诱导G1期停滞。 本文公开的材料和方法包括（1）编码p18或p19的核酸; （2）检测编码p18或p19蛋白质的核酸的方法; （3）分别使用编码p18或p19的核酸产生p18或p19蛋白的方法; （4）纯化的p18或p19蛋白质和肽片段，寡肽或从其衍生的融合蛋白; （5）使用纯化的p18或p19蛋白或其衍生物抑制细胞复制染色体DNA的方法; （6）特异性结合p18或p19的抗体; （7）检测p18和p19蛋白的方法; （8）通过反义寡核苷酸阻断p18或p19表达刺激细胞生长的方法; （9）使用编码p18或p19的核酸进行基因治疗的方法; 和（10）制备在编码p18或p19的基因或两种基因中具有改变的转基因非人动物的方法。

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