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公开(公告)号：US07595395B2
公开(公告)日：2009-09-29
申请号：US11383624
申请日：2006-05-16
Applicant: James M. Cook , Dongmei Han , Terry Clayton
Inventor： James M. Cook , Dongmei Han , Terry Clayton
IPC: C07D487/04
CPC classification number: C07D487/04 , C07D487/14 , C07D519/00
Abstract: The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.
Abstract translation: 本发明提供了用于预防和/或治疗记忆缺陷相关病症和/或增强认知的分子和方法。 在优选的实施方案中，本发明包括用于预防和/或治疗这些病症的化合物，其盐和前药。
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12.发明授权Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings 有权半胱氨酸和胱氨酸前药用于治疗精神分裂症并减少药物渴求公开(公告)号：US08962692B2
公开(公告)日：2015-02-24
申请号：US13465383
申请日：2012-05-07
Applicant: James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
Inventor： James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
IPC: A61K31/095 , A61K31/105 , C07C323/03 , C07C323/64 , C07C327/34 , C07C323/60 , C07D241/08 , C07D487/04 , C07K5/062
CPC classification number: C07D241/08 , A61K9/0053 , C07C323/60 , C07C327/34 , C07D211/86 , C07D487/04 , C07K5/0606
Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.
Abstract translation: 本发明公开了具有以下通式的半胱氨酸前药：具有以下通式的半胱氨酸前药的胱氨酸二聚体：具有以下通式的保护半胱氨酸类似物：具有以下通式的受保护的半胱氨酸类似物的二聚体：本发明还包括含有 公开的前药，二聚体和类似物，以及使用这些化合物治疗精神分裂症和药物成瘾的方法。
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公开(公告)号：US08435997B2
公开(公告)日：2013-05-07
申请号：US12897353
申请日：2010-10-04
Applicant: James M. Cook , Edward Merle Johnson, II , David A. Baker , Wenyuan Yin
Inventor： James M. Cook , Edward Merle Johnson, II , David A. Baker , Wenyuan Yin
IPC: A61K31/497
CPC classification number: C07D241/08
Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。
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公开(公告)号：US08268854B2
公开(公告)日：2012-09-18
申请号：US12471019
申请日：2009-05-22
Applicant: James M. Cook , Michael L. Van Linn , Wenyuan Yin
Inventor： James M. Cook , Michael L. Van Linn , Wenyuan Yin
IPC: C07D471/12 , A61K31/437
CPC classification number: C07D471/04
Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.
Abstract translation: 提供具有根据式（I）的一般结构的化合物：还提供包含这些化合物的药物组合物。 本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。
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15.发明授权Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings 有权半胱氨酸和胱氨酸前药用于治疗精神分裂症并减少药物渴求公开(公告)号：US08173809B2
公开(公告)日：2012-05-08
申请号：US12367867
申请日：2009-02-09
Applicant: James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
Inventor： James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
IPC: C07D295/00
CPC classification number: C07D241/08 , A61K9/0053 , C07C323/60 , C07C327/34 , C07D211/86 , C07D487/04 , C07K5/0606
Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.
Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。 示例性的前药包括具有下式的半胱氨酸化合物及其胱氨酸二聚体。
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Patent Agency Ranking
16.发明申请ANTICONVULSANT AND ANXIOLYTIC METHODS OF USING RECEPTOR SUBTYPE SELECTIVE AGENTS 审中-公开使用受体亚型选择性试剂的抗生素和抗炎方法公开(公告)号：US20100130481A1
公开(公告)日：2010-05-27
申请号：US12684845
申请日：2010-01-08
Applicant: James M. Cook , Qi Huang , Xiaohui He , Xioeyan Li , Jianming Yu , Dongmel Han
Inventor： James M. Cook , Qi Huang , Xiaohui He , Xioeyan Li , Jianming Yu , Dongmel Han
IPC: A61K31/551 , A61P25/22
CPC classification number: C07D471/04 , C07D243/12 , C07D243/20 , C07D243/24 , C07D487/04 , C07D487/06 , C07D495/04 , C07D495/14 , C07D498/04 , C07D519/00
Abstract: Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.
Abstract translation: 公开了使用口服活性苯并二氮杂衍生物及其盐的方法。 这些化合物及其盐具有降低镇静，催眠，肌肉松弛剂或共济失调作用的抗惊厥和抗焦虑活性。
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公开(公告)号：US20090306121A1
公开(公告)日：2009-12-10
申请号：US12471019
申请日：2009-05-22
Applicant: James M. Cook , Michael L. Van Linn , Wenyuan Yin
Inventor： James M. Cook , Michael L. Van Linn , Wenyuan Yin
IPC: A61K31/4375 , C07D471/14 , A61P25/32
CPC classification number: C07D471/04
Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.
Abstract translation: 提供具有根据式（I）的一般结构的化合物：还提供包含这些化合物的药物组合物。 本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。
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18.发明授权Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects 失效具有降低肌肉松弛剂，镇静催眠和共济失调作用的立体特异性抗焦虑药和抗惊厥药公开(公告)号：US07618958B2
公开(公告)日：2009-11-17
申请号：US11173981
申请日：2005-06-30
Applicant: James M. Cook , Hao Zhou , Shengming Huang , P.V.V. Srirama Sarma , Chunchun Zhang
Inventor： James M. Cook , Hao Zhou , Shengming Huang , P.V.V. Srirama Sarma , Chunchun Zhang
IPC: A61P25/22 , A61K31/5513 , C07D243/14 , C07D243/18 , C07D487/04 , C07D495/04 , C07D495/14
CPC classification number: C07D243/24 , C07D243/16 , C07D471/06 , C07D487/04 , C07D487/06
Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.
Abstract translation: 本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法， 效果。 本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-XXI中任一项所示的化学结构和药学上可接受的载体的化合物，前药或盐。
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19.发明申请CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS 有权CYSTININE和CYSTINE PRODRUGS TREAT SCHIZOPHRENIA并减少药物伤口公开(公告)号：US20090281109A1
公开(公告)日：2009-11-12
申请号：US12367867
申请日：2009-02-09
Applicant: James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
Inventor： James M. Cook , David A. Baker , Wenyuan Yin , Edward Merle Johnson, II
IPC: A61K31/497 , C07D241/08 , C07D241/36 , C07D241/04 , A61K31/4965 , C07C69/003 , A61K31/215 , A61K31/225 , A61P25/18 , A61P25/30
CPC classification number: C07D241/08 , A61K9/0053 , C07C323/60 , C07C327/34 , C07D211/86 , C07D487/04 , C07K5/0606
Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。
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公开(公告)号：US07119196B2
公开(公告)日：2006-10-10
申请号：US10402538
申请日：2003-03-28
Applicant: James M. Cook , Qi Huang , Xiaohui He , Xioayan Li , Jianming Yu , Dongmei Han , Snjezana Lelas , John F. McElroy
Inventor： James M. Cook , Qi Huang , Xiaohui He , Xioayan Li , Jianming Yu , Dongmei Han , Snjezana Lelas , John F. McElroy
IPC: C07D487/12
CPC classification number: C07D471/04 , C07D243/12 , C07D243/20 , C07D243/24 , C07D487/04 , C07D487/06 , C07D495/04 , C07D495/14 , C07D498/04 , C07D519/00
Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.
Abstract translation: 公开了口服活性苯二氮卓衍生物及其盐。 这些化合物及其盐具有抗焦虑和抗惊厥活性，降低镇静/催眠/肌肉松弛/共济失调作用。
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