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公开(公告)号：US20110110989A1
公开(公告)日：2011-05-12
申请号：US12866463
申请日：2009-02-11
Applicant: Jean-Thierry Simonnet , Florence L'Alloret , Lydie Bressy , Zohra Moujahed
Inventor： Jean-Thierry Simonnet , Florence L'Alloret , Lydie Bressy , Zohra Moujahed
IPC: A61K8/02 , A61K8/368 , A61K8/64 , A61K8/365 , A61K8/96 , A61K8/66 , A61K8/97 , A61K8/67 , A61K8/99 , A61Q17/04 , A61Q19/00
CPC classification number: A61K8/06 , A61K8/062 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/90 , A61K2800/262 , A61Q1/14 , A61Q19/00
Abstract: The present patent application relates to a composition for topical application in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that it comprises at least one noncrosslinked amphiphilic polymer, the globules of the said emulsion exhibiting a mean size ranging from 15 to 500 microns and the oily phase being present in an amount of less than 35% by weight, with respect to the total weight of the composition.
Abstract translation: 本专利申请涉及以水包油乳状液形式局部施用的组合物，其包含分散在水相中的油相，其特征在于其包含至少一种非交联的两亲性聚合物，所述乳液的小球 表现出15至500微米的平均尺寸，相对于组合物的总重量，油相的存在量小于35重量％。
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12.发明申请公开(公告)号：US20100203004A1
公开(公告)日：2010-08-12
申请号：US12676541
申请日：2008-10-28
Applicant: Jean-Thierry Simonnet , Guillaume Cassin
Inventor： Jean-Thierry Simonnet , Guillaume Cassin
CPC classification number: A61Q19/08 , A61K8/25 , A61K8/645 , A61K8/8152 , A61K8/87
Abstract: The invention relates to a cosmetic composition comprising, in a physiologically acceptable medium, a skin-tensioning agent and an acrylic polymer containing a group of phosphorylcholine type. The invention also relates to a cosmetic skincare process, more particularly for facial skin, in particular wrinkled skin, comprising the application of the composition to the skin.
Abstract translation: 本发明涉及一种化妆品组合物，其在生理上可接受的介质中包含皮肤张力剂和含有一组磷酸胆碱型的丙烯酸类聚合物。 本发明还涉及一种化妆品护肤方法，更具体地涉及面部皮肤，特别是皱纹皮肤，包括将组合物施用于皮肤。
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公开(公告)号：US20090317430A1
公开(公告)日：2009-12-24
申请号：US12438218
申请日：2007-06-29
Applicant: Guillaume Cassin , Jean-Thierry Simonnet
Inventor： Guillaume Cassin , Jean-Thierry Simonnet
CPC classification number: A61K8/8152 , A61K8/0245 , A61K8/466 , A61K8/891 , A61K8/893 , A61K8/895 , A61K8/897 , A61K8/898 , A61K8/899 , A61K2800/412 , A61K2800/42 , A61Q1/02 , A61Q19/02
Abstract: Cosmetic composition for lightening or unifying the complexion The present invention relates to a composition comprising, in a physiologically acceptable medium, concave or annular particles, especially in the form of hollow sphere portions, the said particles comprising a matrix that is coloured in the bulk.
Abstract translation: 用于减轻或统一肤色的化妆品组合物本发明涉及一种组合物，其在生理上可接受的介质中包含凹形或环形颗粒，特别是中空球形部分的形式，所述颗粒包含在本体中着色的基质。
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14.发明申请Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA) 审中-公开至少一种双链RNA寡核苷酸（dsRNA）的局部给药公开(公告)号：US20090117063A1
公开(公告)日：2009-05-07
申请号：US12007387
申请日：2008-01-09
Applicant: Albert Duranton , Christine Collin-Djangone , Francis Pruche , Jean-Thierry Simonnet
Inventor： Albert Duranton , Christine Collin-Djangone , Francis Pruche , Jean-Thierry Simonnet
IPC: A61K31/7088 , A61K31/713 , A61K8/72
CPC classification number: A61Q19/007 , A61K8/606 , A61K31/7088 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C12N2310/13
Abstract: Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to said differentiated cells a thus effective amount of at least one double-stranded RNA oligonucleotide, formulated into a topically applicable, physiologically acceptable medium therefor; such regime or regimen is useful for treating a variety of afflictions or conditions, e.g., combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting cellular proliferation and/or differentiation, etc.
Abstract translation: 编码由分化细胞，特别是皮肤细胞或其附属物表达的蛋白质的信使RNA的表达通过向所述分化的细胞局部给予如此有效量的至少一种双链RNA寡核苷酸而被抑制，所述双链RNA寡核苷酸被配制 成为局部适用的生理上可接受的介质; 这种制度或方案可用于治疗多种疾病或病症，例如抵抗皮肤老化，刺激毛发生长或延缓其损失，抑制细胞增殖和/或分化等症状。
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15.发明授权Compositions comprising a compound of low solubility and a lipophilic amino acid derivative, uses thereof and process for dissolving a compound of low solubility 有权包含低溶解度的化合物和亲脂性氨基酸衍生物的组合物，其用途和溶解低溶解度化合物的方法公开(公告)号：US07485315B2
公开(公告)日：2009-02-03
申请号：US10179231
申请日：2002-06-26
Applicant: Carole Guiramand , Dominique Caplain , Véronique Chevalier , Jean-Thierry Simonnet , Pascal Richart
Inventor： Carole Guiramand , Dominique Caplain , Véronique Chevalier , Jean-Thierry Simonnet , Pascal Richart
CPC classification number: A61Q19/08 , A61K8/37 , A61K8/44 , A61K8/4953 , A61K8/63 , A61K31/506 , A61K31/5685 , A61K31/616 , A61K2800/59 , A61Q5/08 , A61Q19/00 , A61Q19/02
Abstract: The invention relates to a process for dissolving at least one compound of low solubility in water, the said process comprising the essential step of mixing the compound of low solubility with at least one lipophilic amino acid derivative. The invention also relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable medium, at least one compound of low solubility and at least one lipophilic amino acid derivative. Among the compounds of low solubility that are especially included are aminophenol derivatives, salicylic acid derivatives, 2-amino-4-alkylaminopyrimidine 3-oxide derivatives and DHEA, and also its chemical or metabolic derivatives and precursors.
Abstract translation: 本发明涉及将至少一种低溶解度的化合物溶于水的方法，所述方法包括将低溶解度化合物与至少一种亲脂性氨基酸衍生物混合的必要步骤。 本发明还涉及化妆品或皮肤病学组合物，其在生理学上可接受的介质中包含至少一种低溶解度的化合物和至少一种亲脂性氨基酸衍生物。 特别包括的低溶解性化合物是氨基苯酚衍生物，水杨酸衍生物，2-氨基-4-烷基氨基嘧啶3-氧化物衍生物和DHEA，以及其化学或代谢衍生物和前体。
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Patent Agency Ranking
16.发明申请Reconstructed epidermis/skin equivalent comprising a ceramide 7 and/or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds 审中-公开包含神经酰胺7和/或5.5的重建表皮/皮肤等同物和包含神经酰胺7和/或5.5化合物的脂质层状水泡组合物公开(公告)号：US20070148771A1
公开(公告)日：2007-06-28
申请号：US11634078
申请日：2006-12-06
Applicant: Melanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
Inventor： Melanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
IPC: C12N5/08
CPC classification number: A61K8/68 , A61K8/14 , A61Q19/005 , C12N5/0698 , C12N2500/36 , C12N2500/38 , C12N2502/094 , C12N2502/1323 , Y10S514/943
Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.
Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。
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17.发明授权Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds 失效包含神经酰胺7和/或5.5的重建表皮/皮肤等同物和包含神经酰胺7和/或5.5化合物的脂质层状水泡组合物公开(公告)号：US07169382B2
公开(公告)日：2007-01-30
申请号：US10766016
申请日：2004-01-29
Applicant: Mélanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
Inventor： Mélanie Chopart , Isabelle Castiel , Jean-Thierry Simonnet
CPC classification number: A61K8/68 , A61K8/14 , A61Q19/005 , C12N5/0698 , C12N2500/36 , C12N2500/38 , C12N2502/094 , C12N2502/1323 , Y10S514/943
Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.
Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。
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18.发明授权Dibenzoylmethane sunscreen compositions photostabilized with amphiphilic block copolymers 失效二苯甲酰甲烷防晒组合物用两亲嵌段共聚物光稳定化公开(公告)号：US07153494B2
公开(公告)日：2006-12-26
申请号：US10688937
申请日：2003-10-21
Applicant: Sandrine Chodorowski-Kimmes , Francis Xavier Quinn , Jean-Thierry Simonnet
CPC classification number: A61K8/35 , A61K8/90 , A61K2800/52 , A61Q17/04
Abstract: Topically applicable photostable sunscreen/photoprotective compositions contain at least one dibenzoylmethane UV-sunscreen and an effective photostabilizing amount therefor of at least one amphiphilic block copolymer which comprises at least one nonionic hydrophilic polymer block and at least one hydrophobic polymer block, formulated into a topically applicable, cosmetically acceptable medium therefor.
Abstract translation: 局部适用的光稳定防晒剂/光保护组合物含有至少一种二苯甲酰甲烷紫外线防晒剂和至少一种两亲性嵌段共聚物的有效光稳定剂，其包含至少一种非离子亲水性聚合物嵌段和至少一种疏水性聚合物嵌段，其配制成局部适用的 ，化妆品可接受的介质。
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19.发明申请公开(公告)号：US20060263438A1
公开(公告)日：2006-11-23
申请号：US11434828
申请日：2006-05-17
Applicant: Bruno Biatry , Jean-Thierry Simonnet
Inventor： Bruno Biatry , Jean-Thierry Simonnet
CPC classification number: A61Q19/00 , A61K8/025 , A61K8/31 , A61K8/37 , A61K8/44 , A61K8/8152 , A61K8/88 , A61K9/0014 , A61K9/1617 , A61K9/5123 , A61K2800/412 , A61K2800/614 , A61Q19/008
Abstract: The present invention relates to calibrated and spherical oily particles comprising at least one oily phase structured with at least one gelling polymer, characterized in that they have a mean size of less than or equal to 15 μm, in that the said structured oily phase has a melting point of greater than or equal to 40° C. and in that their circularity index is between 0.9 and 1.
Abstract translation: 本发明涉及校准的和球形的油性颗粒，其包含至少一个由至少一种胶凝聚合物构成的油相，其特征在于它们具有小于或等于15μm的平均尺寸，因为所述结构化的油相具有 熔点大于或等于40℃，其圆形度指数在0.9和1之间。
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20.发明授权Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields 失效基于葡萄糖的烷氧基化烯基琥珀酸酯或烷氧基化烯基琥珀酸盐的纳米乳液及其在化妆品，皮肤病学，眼科学和/或药物领域中的用途公开(公告)号：US06461625B1
公开(公告)日：2002-10-08
申请号：US09489839
申请日：2000-01-24
Applicant: Jean-Thierry Simonnet , Odile Sonneville , Sylvie Legret
Inventor： Jean-Thierry Simonnet , Odile Sonneville , Sylvie Legret
IPC: A61K600
CPC classification number: C07D401/06 , Y10S514/844 , Y10S514/873 , Y10S514/937 , Y10S514/938 , Y10S514/939
Abstract: A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.
Abstract translation: 纳米乳剂，其平均粒径小于100nm的纳米乳液，包含选自烷氧基化烯基琥珀酸盐，葡萄糖的烷氧基化烯基琥珀酸盐和甲基葡萄糖的烷氧基化烯基琥珀酸盐的表面活性剂，以及至少一种具有分子 重量大于400，油相量与表面活性剂的重量比为2至10.所获得的乳液在储存时是透明和稳定的。 它可以包含大量的油，同时保持良好的透明度并且同时具有良好的化妆品性质。 它可以构成用于局部使用的组合物，药物组合物或眼科学组合物。
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