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    COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH
    11.
    发明申请
    COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH 有权
    用于增加头发生长的化合物和方法

    公开(公告)号：US20120190733A1

    公开(公告)日：2012-07-26

    申请号：US13354479

    申请日：2012-01-20

    Applicant: Jenny W. Wang ,  David F. Woodward

    Inventor： Jenny W. Wang ,  David F. Woodward

    IPC: A61K31/216 ,  A61P17/14 ,  A61K31/343 ,  A61K31/192 ,  A61K31/381

    CPC classification number: A61K31/5575 ,  A61K8/46 ,  A61K31/575 ,  A61Q7/00

    Abstract: The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7-dithiaPGE1-isopropyl ester is preferred for this treatment.

    Abstract translation: 本发明提供一种用于刺激哺乳动物物种中的毛发生长或将us毛或中间毛转化为末梢毛或刺激毛囊以增加毛发生长的方法，以及选自光泽，光泽，光泽，光泽的一种或多种性质 ，与毛囊相关的头发，发光或光泽的毛发，或增加睫毛或眉毛的长度，厚度，数量和密度中的一种或多种，​​其包括向患者的皮肤施用包含有效量的 EP3激动剂或EP4激动剂前药或其混合物。 用于治疗人或非人动物的皮肤或头皮的这种组合物可以包含有效量的3,7或3和7以及前列腺酸。 这种处理优选3,7-二硫键PGE1和3,7-二硫代磷酸异丙酯的混合物。

    Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
    15.
    发明授权
    Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response 有权
    化合物作用于多种前列腺素受体，产生一般的抗炎反应

    公开(公告)号：US08492424B2

    公开(公告)日：2013-07-23

    申请号：US13170467

    申请日：2011-06-28

    Applicant: William R. Carling ,  Jose L. Martos ,  David F. Woodward ,  Jenny W. Wang ,  Jussi J. Kangasmetsa

    Inventor： William R. Carling ,  Jose L. Martos ,  David F. Woodward ,  Jenny W. Wang ,  Jussi J. Kangasmetsa

    IPC: A61K31/415 ,  C07D231/10

    CPC classification number: C07D231/12 ,  A61K31/415

    Abstract: The present invention provides a compound, that is a 1-[(2-{[(alkyl or aryl)methyl]oxy}halo or haloalkyl substituted-phenyl)alkyl]-5-hydrocarbyl or substituted hydrocarbyl-1H-pyrazole carboxylic acid or alkylenylcarboxylic acid or a hydrocarbyl or substituted hydrocarbyl sulfonamide of said carboxylic acid or said alkylenylcarboxylic acid, provided however said compound is not a 3-carboxylic acid, a sulfonamide thereof, or a 3-methylenylcarboxylic acid. The compound may be represented by the following formula Wherein R1, R2, R3, R4, R5, R6, X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP and/or EP4 receptor mediated diseases or conditions.

    Abstract translation: 本发明提供了化合物，即1 - [（2 - {[（烷基或芳基）甲基]氧基}卤代或卤代烷基取代的 - 苯基）烷基] -5-烃基或取代的烃基-1H-吡唑羧酸或 亚烷基羧酸或所述羧酸或所述烷基烯基羧酸的烃基或取代的烃基磺酰胺，但是所述化合物不是3-羧酸，其磺酰胺或3-甲基烯基羧酸。 该化合物可以由下式表示：其中R1，R2，R3，R4，R5，R6，X，W，X和Y如说明书中所定义。 可以施用化合物以治疗DP1，FP，EP1，TP和/或EP4受体介导的疾病或病症。

    METHOD OF ENHANCING HAIR GROWTH
    17.
    发明申请
    METHOD OF ENHANCING HAIR GROWTH 有权
    增加头发生长的方法

    公开(公告)号：US20120302588A1

    公开(公告)日：2012-11-29

    申请号：US13361615

    申请日：2012-01-30

    Applicant: David F. Woodward ,  Jenny W. Wang

    Inventor： David F. Woodward ,  Jenny W. Wang

    IPC: A61K31/506 ,  A61P17/00 ,  A61P31/10 ,  A61P17/14

    CPC classification number: A61K8/4953 ,  A61K8/42 ,  A61K31/215 ,  A61K31/505 ,  A61K2800/592 ,  A61Q5/00 ,  A61Q7/00 ,  Y10S514/88

    Abstract: Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include bimatoprost and minoxidil in a vehicle for topical application to the skin of a mammal, e.g. a human, whereby the combination of bimatoprost and minoxidil produces a faster onset of hair growth in humans or other mammals and wherein said composition brings about a synergestic result of faster onset of hair growth as compared to compositions comprising bimatoprost and minoxidil, alone.

    Abstract translation: 公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括用于局部施用于哺乳动物皮肤的载体中的比马前列素和米诺地尔。 由此，比马前列素和米诺地尔的组合在人或其它哺乳动物中产生更快的头发生长发生，并且与单独包含比马前列素和米诺地尔的组合物相比，所述组合物产生更快发生头发生长的协同作用。

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